Target Gene/Pathway Pathway / Gene

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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Chemokine signaling pathway 💬

[1] BRAF 💬

Dabrafenib 💬

[1] 34 💬

2

Chemokine signaling pathway 💬

[2] BRAF, RAF1 💬

[2] 34, 86 💬

3

Chemokine signaling pathway 💬

[1] CCL2 💬

Pirfenidone 💬

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

4

Chemokine signaling pathway 💬

[2] CCR2, CCR5 💬

Cenicriviroc 💬

[1] 94 💬

5

Chemokine signaling pathway 💬

[1] CCR4 💬

Mogamulizumab 💬

[1] 26 💬

6

Chemokine signaling pathway 💬

[1] CCR5 💬

[2] 46, 84 💬

7

Chemokine signaling pathway 💬

[2] CXCR1, CXCR2 💬

[2] 298, 299 💬

8

Chemokine signaling pathway 💬

[1] CXCR4 💬

Plerixafor 💬

[5] 19, 20, 65, 285, 299 💬

9

Chemokine signaling pathway 💬

[1] JAK2 💬

Baricitinib 💬

[13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
265	Lipodystrophy;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
325	Hereditary autoinflammatory syndrome;

10

Chemokine signaling pathway 💬

[1] JAK2 💬

Ruxolitinib 💬

[3] 60, 65, 228 💬

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