Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Platelet activation 💬

[1] BTK 💬

Acalabrutinib 💬

[2] 46, 61 💬

2

Platelet activation 💬

[1] BTK 💬

Branebrutinib 💬

[3] 46, 49, 53 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;

3

Platelet activation 💬

[1] BTK 💬

Evobrutinib 💬

[3] 13, 46, 49 💬

4

Platelet activation 💬

[1] BTK 💬

Fenebrutinib 💬

[1] 13 💬

5

Platelet activation 💬

[1] BTK 💬

[3] 28, 60, 61 💬

6

Platelet activation 💬

[1] BTK 💬

Orelabrutinib 💬

[4] 13, 49, 61, 63 💬

7

Platelet activation 💬

[1] BTK 💬

Remibrutinib 💬

[2] 13, 53 💬

8

Platelet activation 💬

[1] BTK 💬

Zanubrutinib 💬

[5] 13, 63, 222, 300, 331 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
222	Primary nephrotic syndrome;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

9

Platelet activation 💬

[1] F2 💬

Dabigatran 💬

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

10

Platelet activation 💬

[1] F2 💬

Dabigatran etexilate 💬

Dabigatran etexilate

[2] 51, 75 💬

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