Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Fc gamma R-mediated phagocytosis 💬

[1] MAP2K1 💬

Binimetinib 💬

[1] 34 💬

2

Fc gamma R-mediated phagocytosis 💬

[1] MAP2K1 💬

Cobimetinib 💬

[1] 280 💬

3

Fc gamma R-mediated phagocytosis 💬

[1] MAP2K1 💬

Mirdametinib 💬

[1] 34 💬

4

Fc gamma R-mediated phagocytosis 💬

[1] MAP2K1 💬

Selumetinib 💬

[1] 34 💬

5

Fc gamma R-mediated phagocytosis 💬

[1] MAP2K1 💬

Trametinib 💬

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

6

Fc gamma R-mediated phagocytosis 💬

[1] PIK3CA 💬

[1] 138 💬

7

Fc gamma R-mediated phagocytosis 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

[2] 53, 65 💬

8

Fc gamma R-mediated phagocytosis 💬

[1] PIK3CD 💬

Parsaclisib 💬

[3] 35, 53, 61 💬

9

Fc gamma R-mediated phagocytosis 💬

[1] PRKCB 💬

Enzastaurin 💬

[1] 168 💬

10

Fc gamma R-mediated phagocytosis 💬

[2] PRKCD, PRKCE 💬

Sotrastaurin 💬

[1] 97 💬

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