Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Insulin secretion 💬

[2] ABCC8, KCNJ11 💬

[2] 13, 193 💬

2

Insulin secretion 💬

[2] ABCC8, KCNJ11 💬

[1] 179 💬

3

Insulin secretion 💬

[2] ABCC8, KCNJ11 💬

Repaglinide 💬

[4] 6 , 21, 46, 299 💬

4

Insulin secretion 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

[1] 299 💬

5

Insulin secretion 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

[3] 8 , 46, 210 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

6

Insulin secretion 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	calcium voltage-gated channel subunit alpha1 C
CACNA1D	calcium voltage-gated channel subunit alpha1 D
CACNA1F	calcium voltage-gated channel subunit alpha1 F
CACNA1S	calcium voltage-gated channel subunit alpha1 S

Amlodipine 💬

[4] 13, 51, 67, 298 💬

7

Insulin secretion 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	calcium voltage-gated channel subunit alpha1 C
CACNA1D	calcium voltage-gated channel subunit alpha1 D
CACNA1F	calcium voltage-gated channel subunit alpha1 F
CACNA1S	calcium voltage-gated channel subunit alpha1 S

Cilnidipine 💬

[1] 67 💬

8

Insulin secretion 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	calcium voltage-gated channel subunit alpha1 C
CACNA1D	calcium voltage-gated channel subunit alpha1 D
CACNA1F	calcium voltage-gated channel subunit alpha1 F
CACNA1S	calcium voltage-gated channel subunit alpha1 S

[3] 51, 58, 86 💬

9

Insulin secretion 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	calcium voltage-gated channel subunit alpha1 C
CACNA1D	calcium voltage-gated channel subunit alpha1 D
CACNA1F	calcium voltage-gated channel subunit alpha1 F
CACNA1S	calcium voltage-gated channel subunit alpha1 S

Isradipine 💬

[1] 6 💬

10

Insulin secretion 💬

[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬

Name	Full Name
CACNA1C	calcium voltage-gated channel subunit alpha1 C
CACNA1D	calcium voltage-gated channel subunit alpha1 D
CACNA1F	calcium voltage-gated channel subunit alpha1 F
CACNA1S	calcium voltage-gated channel subunit alpha1 S

Nicardipine 💬

[2] 70, 86 💬

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