Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Thyroid cancer 💬

[1] BRAF 💬

Dabrafenib 💬

[1] 34 💬

2

Thyroid cancer 💬

[2] BRAF, RET 💬

[2] 34, 86 💬

3

Thyroid cancer 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

[1] 34 💬

4

Thyroid cancer 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

[1] 280 💬

5

Thyroid cancer 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

[1] 34 💬

6

Thyroid cancer 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

[1] 34 💬

7

Thyroid cancer 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

8

Thyroid cancer 💬

[1] PPARG 💬

Bocidelpar 💬

[1] 113 💬

9

Thyroid cancer 💬

[1] PPARG 💬

Leriglitazone 💬

[1] 20 💬

10

Thyroid cancer 💬

[1] PPARG 💬

Pioglitazone 💬

[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
20	Adrenoleukodystrophy;ALD;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
96	Crohn disease;Terminal ileitis;
229	Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP;
265	Lipodystrophy;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

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