Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	CDK4	[25] Endocrine resistance, Cell cycle, p53 signaling pathway, PI3K-Akt signaling pathway, Cellular s ...	D10688	Abemaciclib	[1] 34
2	CDK6	[22] Cell cycle, p53 signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Cushing syn ...	D10688	Abemaciclib	[1] 34
3	ABL1	[10] ErbB signaling pathway, Ras signaling pathway, Cell cycle, Neurotrophin signaling pathway, Path ...	D03252	Bosutinib	[2] 2, 67
4	ABL1	[10] ErbB signaling pathway, Ras signaling pathway, Cell cycle, Neurotrophin signaling pathway, Path ...	D03658	Dasatinib	[2] 51, 85
5	ABL1	[10] ErbB signaling pathway, Ras signaling pathway, Cell cycle, Neurotrophin signaling pathway, Path ...	D06414	Dasatinib	[2] 51, 85
6	ABL1	[10] ErbB signaling pathway, Ras signaling pathway, Cell cycle, Neurotrophin signaling pathway, Path ...	D08066	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
7	ABL1	[10] ErbB signaling pathway, Ras signaling pathway, Cell cycle, Neurotrophin signaling pathway, Path ...	D08953	Nilotinib	[5] 6, 8, 34, 51, 86
8	ABL1	[10] ErbB signaling pathway, Ras signaling pathway, Cell cycle, Neurotrophin signaling pathway, Path ...	D09664	Saracatinib	[3] 6, 89, 272
9	HDAC1	[13] Cell cycle, Longevity regulating pathway - multiple species, Notch signaling pathway, Neutrophi ...	D06320	Vorinostat	[2] 75, 96
10	HDAC2	[13] Cell cycle, Longevity regulating pathway - multiple species, Notch signaling pathway, Neutrophi ...	D06320	Vorinostat	[2] 75, 96

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