Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D00150 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
2 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D02014 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
3 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D00522 💬 Candesartan [2] 58, 67 💬
4 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D00626 💬 Candesartan cilexetil [1] 67 💬
5 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D00523 💬 Irbesartan [4] 66, 167, 168, 222 💬
6 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D08146 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
7 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D11776 💬 Sparsentan [3] 66, 218, 222 💬
8 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D00627 💬 Telmisartan [2] 66, 67 💬
9 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 D00400 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
10 Phospholipase D signaling pathway 💬
 [3] AVPR1A, AVPR1B, AVPR2 💬 D06672 💬 Terlipressin [1] 299 💬
11 Phospholipase D signaling pathway 💬
 [3] AVPR1A, AVPR1B, AVPR2 💬 D00101 💬 Vasopressin [1] 210 💬
12 Phospholipase D signaling pathway 💬
 [2] AVPR1A, AVPR2 💬 D07748 💬 Conivaptan [1] 86 💬
13 Phospholipase D signaling pathway 💬
 [1] AVPR2 💬 D00291 💬 Desmopressin [6]  6 , 64, 72, 75, 225, 288 💬
14 Phospholipase D signaling pathway 💬
 [1] AVPR2 💬 D04752 💬 Lixivaptan [1] 67 💬
15 Phospholipase D signaling pathway 💬
 [1] AVPR2 💬 D01213 💬 Tolvaptan [4] 67, 72, 86, 225 💬
16 Phospholipase D signaling pathway 💬
 [2] CXCR1, CXCR2 💬 D08984 💬 Reparixin [2] 298, 299 💬
17 Phospholipase D signaling pathway 💬
 [1] EGFR 💬 D03455 💬 Cetuximab [2] 51, 86 💬
18 Phospholipase D signaling pathway 💬
 [1] EGFR 💬 D07907 💬 Erlotinib [1] 94 💬
19 Phospholipase D signaling pathway 💬
 [1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
20 Phospholipase D signaling pathway 💬
 [1] EGFR 💬 D11251 💬 Icotinib [1] 34 💬
21 Phospholipase D signaling pathway 💬
 [1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
22 Phospholipase D signaling pathway 💬
 [1] EGFR 💬 D08950 💬 Neratinib [1] 34 💬
23 Phospholipase D signaling pathway 💬
 [1] EGFR 💬 D11772 💬 Tesevatinib [1] 67 💬
24 Phospholipase D signaling pathway 💬
 [1] F2 💬 D09707 💬 Dabigatran [5] 51, 75, 85, 91, 124 💬
25 Phospholipase D signaling pathway 💬
 [1] F2 💬 D07144 💬 Dabigatran etexilate [2] 51, 75 💬
26 Phospholipase D signaling pathway 💬
 [1] F2 💬 D06410 💬 Thrombomodulin Alfa [1] 85 💬
27 Phospholipase D signaling pathway 💬
 [1] FCER1A 💬 D05251 💬 Omalizumab [7] 46, 53, 65, 98, 162, 226, 299 💬
28 Phospholipase D signaling pathway 💬
 [3] FYN, KIT, PDGFRB 💬 D03658 💬 Dasatinib [2] 51, 85 💬
29 Phospholipase D signaling pathway 💬
 [3] FYN, KIT, PDGFRB 💬 D06414 💬 Dasatinib [2] 51, 85 💬
30 Phospholipase D signaling pathway 💬
 [1] INSR 💬 D04539 💬 Insulin detemir [1] 299 💬
31 Phospholipase D signaling pathway 💬
 [1] INSR 💬 D03250 💬 Insulin glargine [1] 299 💬
32 Phospholipase D signaling pathway 💬
 [1] INSR 💬 D03230 💬 Insulin human [2] 96, 156 💬
33 Phospholipase D signaling pathway 💬
 [1] KIT 💬 D10229 💬 Masitinib [6]  2 ,  5 ,  6 , 13, 46, 96 💬
34 Phospholipase D signaling pathway 💬
 [1] KIT 💬 D11270 💬 Pexidartinib [1] 34 💬
35 Phospholipase D signaling pathway 💬
 [2] KIT, PDGFRA 💬 D08066 💬 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
36 Phospholipase D signaling pathway 💬
 [3] KIT, PDGFRA, PDGFRB 💬 D08953 💬 Nilotinib [5]  6 ,  8 , 34, 51, 86 💬
37 Phospholipase D signaling pathway 💬
 [3] KIT, PDGFRA, PDGFRB 💬 D08552 💬 Sunitinib [2] 28, 34 💬
38 Phospholipase D signaling pathway 💬
 [3] KIT, PDGFRB, RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
39 Phospholipase D signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
40 Phospholipase D signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
41 Phospholipase D signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D11675 💬 Mirdametinib [1] 34 💬
42 Phospholipase D signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
43 Phospholipase D signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
44 Phospholipase D signaling pathway 💬
 [1] MTOR 💬 D02714 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
45 Phospholipase D signaling pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
46 Phospholipase D signaling pathway 💬
 [1] MTOR 💬 D06068 💬 Temsirolimus [1] 13 💬
47 Phospholipase D signaling pathway 💬
 [2] PDGFRA, PDGFRB 💬 D10481 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
48 Phospholipase D signaling pathway 💬
 [1] PIK3CA 💬 D11011 💬 Alpelisib [1] 138 💬
49 Phospholipase D signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
50 Phospholipase D signaling pathway 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
51 Phospholipase D signaling pathway 💬
 [1] PTGFR 💬 D06274 💬 Tafluprost [1] 299 💬
52 Phospholipase D signaling pathway 💬
 [1] PTGFR 💬 D08661 💬 Unoprostone [1] 90 💬
53 Phospholipase D signaling pathway 💬
 [1] SYK 💬 D09347 💬 Fostamatinib [4] 46, 49, 61, 66 💬