Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 ADORA1 💬 7件: cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
2 ADORA1 💬 7件: cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
3 ADORA2A 💬 7件: Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Parkinson disease, Alcoholism Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
4 ADORA2A 💬 7件: Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Parkinson disease, Alcoholism Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
5 APOC3 💬 2件: PPAR signaling pathway, Cholesterol metabolism Volanesorsen 💬 Volanesorsen 1件: 265 💬
6 GHR 💬 5件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action Pegvisomant 💬 Pegvisomant 2件: 78, 265 💬
7 GHR 💬 5件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Growth hormone synthesis, secretion and action Mecasermin 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
8 GHRHR 💬 2件: Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Tesamorelin 💬 Tesamorelin 2件: 78, 265 💬
9 HMGCR 💬 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion Pravastatin 💬 Pravastatin 9件: 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
10 HMGCR 💬 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion Simvastatin 💬 Simvastatin 21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
11 HMGCR 💬 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion Atorvastatin 💬 Atorvastatin 19件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
12 IGF1R 💬 29件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Oocyte meiosis, Autophagy - animal, Endocytosis, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Focal adhesion, Adherens junction, Signaling pathways regulating pluripotency of stem cells, Long-term depression, Ovarian steroidogenesis, Progesterone-mediated oocyte maturation, Pathways in cancer, Transcriptional misregulation in cancer, Proteoglycans in cancer, Glioma, Prostate cancer, Melanoma, Breast cancer, Hepatocellular carcinoma Mecasermin 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
13 JAK1 💬 27件: EGFR tyrosine kinase inhibitor resistance, PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Leishmaniasis, Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer, Viral carcinogenesis, Pancreatic cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer Baricitinib 💬 Baricitinib 13件: 2, 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
14 JAK2 💬 24件: EGFR tyrosine kinase inhibitor resistance, Chemokine signaling pathway, PI3K-Akt signaling pathway, Necroptosis, Signaling pathways regulating pluripotency of stem cells, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Cholinergic synapse, Prolactin signaling pathway, Adipocytokine signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Growth hormone synthesis, secretion and action, Leishmaniasis, Toxoplasmosis, Tuberculosis, Hepatitis B, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Pathways in cancer, Chemical carcinogenesis - receptor activation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Baricitinib 💬 Baricitinib 13件: 2, 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
15 LEPR 💬 6件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, AMPK signaling pathway, JAK-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease Metreleptin 💬 Metreleptin 1件: 265 💬
16 MC4R 💬 1件: Neuroactive ligand-receptor interaction Setmelanotide 💬 Setmelanotide 2件: 202, 265 💬
17 NR1H4 💬 1件: Bile secretion Cholic acid 💬 Cholic Acid 4件: 20, 234, 265, 310 💬
18 NR1H4 💬 1件: Bile secretion Obeticholic acid 💬 Obeticholic acid 3件: 93, 265, 296 💬
19 PDE1B 💬 7件: Purine metabolism, Metabolic pathways, Calcium signaling pathway, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
20 PDE1B 💬 7件: Purine metabolism, Metabolic pathways, Calcium signaling pathway, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
21 PDE2A 💬 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, Olfactory transduction, Aldosterone synthesis and secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
22 PDE2A 💬 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, Olfactory transduction, Aldosterone synthesis and secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
23 PDE3A 💬 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
24 PDE3A 💬 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
25 PDE3B 💬 11件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
26 PDE3B 💬 11件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
27 PDE4A 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
28 PDE4A 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
29 PDE4B 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
30 PDE4B 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
31 PDE4C 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
32 PDE4C 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
33 PDE4D 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
34 PDE4D 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
35 PDE5A 💬 3件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
36 PDE5A 💬 3件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
37 PPARA 💬 10件: PPAR signaling pathway, cAMP signaling pathway, Adipocytokine signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hepatitis C, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy Fenofibrate 💬 Fenofibrate 6件: 8, 79, 93, 94, 97, 265 💬
38 PPARG 💬 11件: PPAR signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Rosiglitazone 💬 Rosiglitazone 5件: 46, 75, 97, 222, 265 💬
39 PPARG 💬 11件: PPAR signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis Pioglitazone 💬 Pioglitazone 17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
40 PRKAA1 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin 💬 Metformin 25件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
41 PRKAA2 💬 20件: FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis Metformin 💬 Metformin 25件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬