Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 CA5B 💬 2件: Nitrogen metabolism, Metabolic pathways Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬
2 CA5B 💬 2件: Nitrogen metabolism, Metabolic pathways Dorzolamide 💬 Dorzolamide 1件: 90 💬
3 ADRA2A 💬 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction Brimonidine 💬 Brimonidine 2件: 13, 90 💬
4 ADRA2B 💬 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction Brimonidine 💬 Brimonidine 2件: 13, 90 💬
5 ADRA2C 💬 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction Brimonidine 💬 Brimonidine 2件: 13, 90 💬
6 DDC 💬 9件: Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Dopaminergic synapse, Cocaine addiction, Amphetamine addiction, Alcoholism Carbidopa 💬 Carbidopa 7件: 6, 13, 17, 90, 140, 164, 201 💬
7 DRD1 💬 10件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Morphine addiction, Alcoholism Levodopa 💬 Levodopa 6件: 6, 17, 90, 140, 164, 201 💬
8 DRD2 💬 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Levodopa 💬 Levodopa 6件: 6, 17, 90, 140, 164, 201 💬
9 DRD3 💬 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse Levodopa 💬 Levodopa 6件: 6, 17, 90, 140, 164, 201 💬
10 DRD4 💬 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse Levodopa 💬 Levodopa 6件: 6, 17, 90, 140, 164, 201 💬
11 DRD5 💬 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Dopaminergic synapse Levodopa 💬 Levodopa 6件: 6, 17, 90, 140, 164, 201 💬
12 ABAT 💬 7件: Alanine, aspartate and glutamate metabolism, Valine, leucine and isoleucine degradation, beta-Alanine metabolism, Propanoate metabolism, Butanoate metabolism, Metabolic pathways, GABAergic synapse Valproic acid 💬 Valproic acid 14件: 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
13 CA14 💬 2件: Nitrogen metabolism, Metabolic pathways Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬
14 CA14 💬 2件: Nitrogen metabolism, Metabolic pathways Dorzolamide 💬 Dorzolamide 1件: 90 💬
15 GAD1 💬 7件: Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Taurine and hypotaurine metabolism, Butanoate metabolism, Metabolic pathways, GABAergic synapse, Type I diabetes mellitus Valproic acid 💬 Valproic acid 14件: 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
16 GAD2 💬 7件: Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Taurine and hypotaurine metabolism, Butanoate metabolism, Metabolic pathways, GABAergic synapse, Type I diabetes mellitus Valproic acid 💬 Valproic acid 14件: 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
17 NR3C1 💬 1件: Neuroactive ligand-receptor interaction Betamethasone 💬 Betamethasone 8件: 2, 28, 46, 65, 83, 90, 96, 235 💬
18 NR3C1 💬 1件: Neuroactive ligand-receptor interaction Triamcinolone 💬 Triamcinolone 11件: 35, 46, 53, 56, 70, 90, 96, 107, 162, 226, 298 💬
19 NR3C1 💬 1件: Neuroactive ligand-receptor interaction Fluocinolone acetonide 💬 Fluocinolone acetonide 1件: 90 💬
20 CA13 💬 2件: Nitrogen metabolism, Metabolic pathways Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬
21 CA13 💬 2件: Nitrogen metabolism, Metabolic pathways Dorzolamide 💬 Dorzolamide 1件: 90 💬
22 MTNR1A 💬 2件: Neuroactive ligand-receptor interaction, Circadian entrainment Melatonin 💬 Melatonin 12件: 6, 8, 13, 37, 46, 49, 72, 78, 90, 97, 145, 202 💬
23 MTNR1B 💬 2件: Neuroactive ligand-receptor interaction, Circadian entrainment Melatonin 💬 Melatonin 12件: 6, 8, 13, 37, 46, 49, 72, 78, 90, 97, 145, 202 💬
24 NGFR 💬 9件: Virion - Lyssavirus, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Apoptosis - multiple species, Neurotrophin signaling pathway, Transcriptional misregulation in cancer Cenegermin 💬 Cenegermin 2件: 53, 90 💬
25 PGF 💬 6件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Pathways in cancer Aflibercept 💬 Aflibercept 2件: 90, 166 💬
26 PPP3CA 💬 33件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Cyclosporine 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
27 PPP3CB 💬 33件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Cyclosporine 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
28 PPP3CC 💬 33件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Cyclosporine 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
29 PPP3R1 💬 32件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Cyclosporine 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
30 PPP3R2 💬 32件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Cyclosporine 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
31 PTGFR 💬 3件: Calcium signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction Unoprostone 💬 Unoprostone 1件: 90 💬
32 RARA 💬 5件: Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia Vitamin A 💬 Vitamin A 3件: 13, 53, 90 💬
33 RARB 💬 4件: Pathways in cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer Vitamin A 💬 Vitamin A 3件: 13, 53, 90 💬
34 VEGFA 💬 24件: EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Renal cell carcinoma, Pancreatic cancer, Bladder cancer, Rheumatoid arthritis, Fluid shear stress and atherosclerosis Aflibercept 💬 Aflibercept 2件: 90, 166 💬
35 VEGFB 💬 9件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Pathways in cancer Aflibercept 💬 Aflibercept 2件: 90, 166 💬
36 CA1 💬 2件: Nitrogen metabolism, Metabolic pathways Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬
37 CA1 💬 2件: Nitrogen metabolism, Metabolic pathways Dorzolamide 💬 Dorzolamide 1件: 90 💬
38 CA2 💬 7件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬
39 CA2 💬 7件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Dorzolamide 💬 Dorzolamide 1件: 90 💬
40 CA3 💬 2件: Nitrogen metabolism, Metabolic pathways Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬
41 CA3 💬 2件: Nitrogen metabolism, Metabolic pathways Dorzolamide 💬 Dorzolamide 1件: 90 💬
42 CA4 💬 3件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬
43 CA4 💬 3件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation Dorzolamide 💬 Dorzolamide 1件: 90 💬
44 CA5A 💬 2件: Nitrogen metabolism, Metabolic pathways Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬
45 CA5A 💬 2件: Nitrogen metabolism, Metabolic pathways Dorzolamide 💬 Dorzolamide 1件: 90 💬
46 CA6 💬 2件: Nitrogen metabolism, Metabolic pathways Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬
47 CA6 💬 2件: Nitrogen metabolism, Metabolic pathways Dorzolamide 💬 Dorzolamide 1件: 90 💬
48 CA7 💬 2件: Nitrogen metabolism, Metabolic pathways Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬
49 CA7 💬 2件: Nitrogen metabolism, Metabolic pathways Dorzolamide 💬 Dorzolamide 1件: 90 💬
50 CA8 💬 2件: Nitrogen metabolism, Metabolic pathways Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬
51 CA8 💬 2件: Nitrogen metabolism, Metabolic pathways Dorzolamide 💬 Dorzolamide 1件: 90 💬
52 CA9 💬 2件: Nitrogen metabolism, Metabolic pathways Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬
53 CA9 💬 2件: Nitrogen metabolism, Metabolic pathways Dorzolamide 💬 Dorzolamide 1件: 90 💬
54 CA12 💬 2件: Nitrogen metabolism, Metabolic pathways Acetazolamide 💬 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230 💬
55 CA12 💬 2件: Nitrogen metabolism, Metabolic pathways Dorzolamide 💬 Dorzolamide 1件: 90 💬
56 CACNA1C 💬 34件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Nilvadipine 💬 Nilvadipine 1件: 90 💬
57 CACNA1D 💬 35件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Tight junction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Carbohydrate digestion and absorption, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Nilvadipine 💬 Nilvadipine 1件: 90 💬
58 CACNA1F 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Nilvadipine 💬 Nilvadipine 1件: 90 💬
59 CACNA1S 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Nilvadipine 💬 Nilvadipine 1件: 90 💬
60 ALDH5A1 💬 3件: Alanine, aspartate and glutamate metabolism, Butanoate metabolism, Metabolic pathways Valproic acid 💬 Valproic acid 14件: 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
61 PDE5A 💬 3件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway Sildenafil 💬 Sildenafil 17件: 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
62 CACNA1I 💬 7件: MAPK signaling pathway, Calcium signaling pathway, Circadian entrainment, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome Valproic acid 💬 Valproic acid 14件: 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
63 CACNA1H 💬 7件: MAPK signaling pathway, Calcium signaling pathway, Circadian entrainment, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome Valproic acid 💬 Valproic acid 14件: 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
64 CACNA1G 💬 8件: MAPK signaling pathway, Calcium signaling pathway, Circadian entrainment, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome Valproic acid 💬 Valproic acid 14件: 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬