Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 DHFR 💬 [5] One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, Antifolate resistance Methotrexate 💬 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
2 DHODH 💬 [3] Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors Leflunomide 💬 Leflunomide [12] 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300 💬
3 DHODH 💬 [3] Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors Teriflunomide 💬 Teriflunomide [3] 13, 25, 26 💬
4 NQO1 💬 [7] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Biosynthesis of cofactors, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Warfarin 💬 Warfarin [11] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
5 DHFR2 💬 [5] One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, Antifolate resistance Methotrexate 💬 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
6 ALAS1 💬 [4] Glycine, serine and threonine metabolism, Porphyrin metabolism, Metabolic pathways, Biosynthesis of cofactors Hemin 💬 Hemin [1] 254 💬
7 ALAS1 💬 [4] Glycine, serine and threonine metabolism, Porphyrin metabolism, Metabolic pathways, Biosynthesis of cofactors Givosiran 💬 Givosiran [1] 254 💬
8 ALAS2 💬 [4] Glycine, serine and threonine metabolism, Porphyrin metabolism, Metabolic pathways, Biosynthesis of cofactors Hemin 💬 Hemin [1] 254 💬
9 ALPL 💬 [4] Thiamine metabolism, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors Asfotase alfa 💬 Asfotase alfa [1] 172 💬
10 GUSB 💬 [8] Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Glycosaminoglycan degradation, Porphyrin metabolism, Drug metabolism - other enzymes, Metabolic pathways, Biosynthesis of cofactors, Lysosome Vestronidase alfa 💬 Vestronidase alfa [1] 19 💬
11 HPD 💬 [5] Ubiquinone and other terpenoid-quinone biosynthesis, Tyrosine metabolism, Phenylalanine metabolism, Metabolic pathways, Biosynthesis of cofactors Nitisinone 💬 Nitisinone [3] 6, 164, 241 💬
12 VKORC1 💬 [3] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Biosynthesis of cofactors Phenindione 💬 Phenindione [1] 65 💬
13 VKORC1 💬 [3] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Biosynthesis of cofactors Warfarin 💬 Warfarin [11] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91 💬