Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Adherens junction 💬

[1] IGF1R 💬

Mecasermin 💬

[6] 65, 78, 96, 168, 265, 299 💬

2

Adrenergic signaling in cardiomyocytes 💬

[1] ADRB1 💬

Celiprolol 💬

[1] 168 💬

3

Adrenergic signaling in cardiomyocytes 💬

[1] AGTR1 💬

Irbesartan 💬

[4] 66, 167, 168, 222 💬

4

Adrenergic signaling in cardiomyocytes 💬

[1] SCN5A 💬

Bupivacaine 💬

[8] 46, 51, 53, 70, 96, 168, 226, 298 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
70	Spinal stenosis;Extensive spinal canal stenosis;
96	Crohn disease;Terminal ileitis;
168	Ehlers-Danlos syndrome;EDS;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
298	Hereditary pancreatitis;Chronic pancreatitis;

5

Adrenergic signaling in cardiomyocytes 💬

[1] SCN5A 💬

[13] 6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
107	Juvenile idiopathic arthritis;JIA;
168	Ehlers-Danlos syndrome;EDS;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

6

Adrenergic signaling in cardiomyocytes 💬

[1] SCN5A 💬

Lidocaine hydrochloride monohydrate 💬

Name	Other Names
Lidocaine hydrochloride monohydrate	Lidocaine hydrochloride monohydrate Lidocaine (TN) Zingo (TN) 1% LIDOCAINE HCI 2% LIDOCAINE HCI LIDENZAL 1% LIDENZAL 2% LIDOCAINE HCI LIDOCAINE HCL LIDOCAINE HYDROCHLORIDE NA PRELIDOPINE PRE-OPERATIVE SYSTEM

[13] 6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
22	Moyamoya disease;Occlusive disease in circle of Willis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
107	Juvenile idiopathic arthritis;JIA;
168	Ehlers-Danlos syndrome;EDS;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;

7

African trypanosomiasis 💬

[1] PRKCB 💬

Enzastaurin 💬

[1] 168 💬

8

AGE-RAGE signaling pathway in diabetic complications 💬

[1] AGTR1 💬

Irbesartan 💬

[4] 66, 167, 168, 222 💬

9

AGE-RAGE signaling pathway in diabetic complications 💬

[1] PRKCB 💬

Enzastaurin 💬

[1] 168 💬

10

Aldosterone synthesis and secretion 💬

[1] AGTR1 💬

Irbesartan 💬

[4] 66, 167, 168, 222 💬

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