Target Gene/Pathway Pathway / Gene

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No.

KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[11] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive liga ...

Celiprolol 💬

[1] 168 💬

2

[16] Calcium signaling pathway, cGMP-PKG signaling pathway, Phospholipase D signaling pathway, Neuro ...

Irbesartan 💬

[4] 66, 167, 168, 222 💬

3

[5] Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signal ...

Mecasermin 💬

[6] 65, 78, 96, 168, 265, 299 💬

4

[29] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, Ras si ...

Mecasermin 💬

[6] 65, 78, 96, 168, 265, 299 💬

5

[4] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Oxyt ...

[7] 6, 72, 127, 168, 193, 206, 226 💬

Disease ID	Name
6	Parkinson disease
72	Pituitary ADH secretion disorder
127	Frontotemporal lobar degeneration
168	Ehlers-Danlos syndrome
193	Prader-Willi syndrome
206	Fragile X syndrome
226	Interstitial cystitis with Hunners ulcer

6

[71] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, ErbB signaling pathway, Ras ...

Enzastaurin 💬

[1] 168 💬

7

[1] Dopaminergic synapse

[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬

Disease ID	Name
6	Parkinson disease
13	Multiple sclerosis/Neuromyelitis optica
22	Moyamoya disease
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
51	Scleroderma
70	Spinal stenosis
84	Sarcoidosis
86	Pulmonary arterial hypertension
107	Juvenile idiopathic arthritis
168	Ehlers-Danlos syndrome
226	Interstitial cystitis with Hunners ulcer
256	Muscle glycogenosis

8

[1] Dopaminergic synapse

Bupivacaine 💬

[8] 46, 51, 53, 70, 96, 168, 226, 298 💬

Disease ID	Name
46	Malignant rheumatoid arthritis
51	Scleroderma
53	Sjogren syndrome
70	Spinal stenosis
96	Crohn disease
168	Ehlers-Danlos syndrome
226	Interstitial cystitis with Hunners ulcer
298	Hereditary pancreatitis

9

[1] Dopaminergic synapse

Lidocaine hydrochloride monohydrate 💬

Name	Other Names
Lidocaine hydrochloride monohydrate	Lidocaine hydrochloride monohydrate Lidocaine (TN) Zingo (TN) 1% LIDOCAINE HCI 2% LIDOCAINE HCI LIDENZAL 1% LIDENZAL 2% LIDOCAINE HCI LIDOCAINE HCL LIDOCAINE HYDROCHLORIDE NA PRELIDOPINE PRE-OPERATIVE SYSTEM

[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬

Disease ID	Name
6	Parkinson disease
13	Multiple sclerosis/Neuromyelitis optica
22	Moyamoya disease
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
51	Scleroderma
70	Spinal stenosis
84	Sarcoidosis
86	Pulmonary arterial hypertension
107	Juvenile idiopathic arthritis
168	Ehlers-Danlos syndrome
226	Interstitial cystitis with Hunners ulcer
256	Muscle glycogenosis

10

[1] Taste transduction

[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬

Disease ID	Name
6	Parkinson disease
13	Multiple sclerosis/Neuromyelitis optica
22	Moyamoya disease
34	Neurofibromatosis
46	Malignant rheumatoid arthritis
51	Scleroderma
70	Spinal stenosis
84	Sarcoidosis
86	Pulmonary arterial hypertension
107	Juvenile idiopathic arthritis
168	Ehlers-Danlos syndrome
226	Interstitial cystitis with Hunners ulcer
256	Muscle glycogenosis

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