Target Gene/Pathway Pathway / Gene
Search results
No. | KEGG PATHWAY | KEGG GENES | KEGG DRUG | DrugBank | Disease ID |
---|---|---|---|---|---|
1 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
ADRA1A [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
2 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
3 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
4 | Aldosterone-regulated sodium reabsorption 💬 13 genes, 14 drugs (DrugBank) and 25 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
5 | Aldosterone-regulated sodium reabsorption 💬 13 genes, 14 drugs (DrugBank) and 25 diseases |
NR3C2 [1] NR3C2 💬 |
Eplerenone Eplerenone 💬 |
Eplerenone | 075 [4] 75, 113, 210, 215 💬 💬 |
6 | Aldosterone-regulated sodium reabsorption 💬 13 genes, 14 drugs (DrugBank) and 25 diseases |
NR3C2 [1] NR3C2 💬 |
Spironolactone Spironolactone 💬 |
Spironolactone | 046 [8] 46, 58, 67, 86, 113, 210, 218, 225 💬 💬 |
7 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
8 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
9 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
ADRA1A [1] ADRA1A 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
10 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
11 | Arachidonic acid metabolism 💬 4 genes, 26 drugs (DrugBank) and 43 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
12 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
13 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
14 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADRA1A [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
15 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
AVPR1A [2] AVPR1A, AVPR1B 💬 |
Vasopressin Vasopressin 💬 |
Vasopressin | 210 [1] 210 💬 💬 |
16 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
EDNRA [1] EDNRA 💬 |
Ambrisentan Ambrisentan 💬 |
Ambrisentan | 051 [7] 51, 84, 85, 86, 88, 210, 211 💬 💬 |
17 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
EDNRA [2] EDNRA, EDNRB 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
18 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
EDNRA [2] EDNRA, EDNRB 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
19 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
EDNRA [2] EDNRA, EDNRB 💬 |
Macitentan Macitentan 💬 |
Macitentan | 051 [5] 51, 85, 86, 88, 210 💬 💬 |
20 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADRB1 [2] ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
21 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
22 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
EDNRA [1] EDNRA 💬 |
Ambrisentan Ambrisentan 💬 |
Ambrisentan | 051 [7] 51, 84, 85, 86, 88, 210, 211 💬 💬 |
23 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
EDNRA [1] EDNRA 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
24 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
EDNRA [1] EDNRA 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
25 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
EDNRA [1] EDNRA 💬 |
Macitentan Macitentan 💬 |
Macitentan | 051 [5] 51, 85, 86, 88, 210 💬 💬 |
26 | Carbohydrate digestion and absorption 💬 14 genes, 19 drugs (DrugBank) and 30 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
27 | Cardiac muscle contraction 💬 13 genes, 17 drugs (DrugBank) and 26 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
28 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRA1A [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
29 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
30 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
EDNRA [1] EDNRA 💬 |
Ambrisentan Ambrisentan 💬 |
Ambrisentan | 051 [7] 51, 84, 85, 86, 88, 210, 211 💬 💬 |
31 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
EDNRA [2] EDNRA, EDNRB 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
32 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
EDNRA [2] EDNRA, EDNRB 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
33 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
EDNRA [2] EDNRA, EDNRB 💬 |
Macitentan Macitentan 💬 |
Macitentan | 051 [5] 51, 85, 86, 88, 210 💬 💬 |
34 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
PDE5A [1] PDE5A 💬 |
Sildenafil Sildenafil 💬 |
Sildenafil | 006 [17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 💬 |
35 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
PDE5A [1] PDE5A 💬 |
Tadalafil Tadalafil 💬 |
Tadalafil | 006 [7] 6 , 51, 75, 84, 86, 113, 210 💬 💬 |
36 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
PDE5A [1] PDE5A 💬 |
Udenafil Udenafil 💬 |
Udenafil | 086 [2] 86, 210 💬 💬 |
37 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
ACE [1] ACE 💬 |
Enalapril Enalapril 💬 |
Enalapril | 019 [6] 19, 46, 66, 113, 210, 222 💬 💬 |
38 | Chemical carcinogenesis - DNA adducts 💬 1 gene, 24 drugs (DrugBank) and 40 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
39 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
ADRB1 [2] ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
40 | Complement and coagulation cascades 💬 17 genes, 29 drugs (DrugBank) and 44 diseases |
F10 [1] F10 💬 |
Rivaroxaban Rivaroxaban 💬 |
Rivaroxaban | 046 [4] 46, 49, 91, 210 💬 💬 |
41 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
ACE [1] ACE 💬 |
Enalapril Enalapril 💬 |
Enalapril | 019 [6] 19, 46, 66, 113, 210, 222 💬 💬 |
42 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
ACE [1] ACE 💬 |
Enalapril Enalapril 💬 |
Enalapril | 019 [6] 19, 46, 66, 113, 210, 222 💬 💬 |
43 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
ADRB1 [1] ADRB1 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
44 | Endocrine and other factor-regulated calcium reabsorption 💬 8 genes, 27 drugs (DrugBank) and 55 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
45 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
ADRB1 [1] ADRB1 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
46 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
47 | Gastric acid secretion 💬 14 genes, 43 drugs (DrugBank) and 52 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
48 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
49 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
50 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
51 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Enalapril Enalapril 💬 |
Enalapril | 019 [6] 19, 46, 66, 113, 210, 222 💬 💬 |
52 | IL-17 signaling pathway 💬 20 genes, 60 drugs (DrugBank) and 83 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
53 | Insulin secretion 💬 14 genes, 39 drugs (DrugBank) and 44 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
54 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
55 | Leishmaniasis 💬 25 genes, 63 drugs (DrugBank) and 93 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
56 | Melanogenesis 💬 7 genes, 16 drugs (DrugBank) and 29 diseases |
EDNRB [1] EDNRB 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
57 | Melanogenesis 💬 7 genes, 16 drugs (DrugBank) and 29 diseases |
EDNRB [1] EDNRB 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
58 | Melanogenesis 💬 7 genes, 16 drugs (DrugBank) and 29 diseases |
EDNRB [1] EDNRB 💬 |
Macitentan Macitentan 💬 |
Macitentan | 051 [5] 51, 85, 86, 88, 210 💬 💬 |
59 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PDE5A [1] PDE5A 💬 |
Sildenafil Sildenafil 💬 |
Sildenafil | 006 [17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 💬 |
60 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PDE5A [1] PDE5A 💬 |
Tadalafil Tadalafil 💬 |
Tadalafil | 006 [7] 6 , 51, 75, 84, 86, 113, 210 💬 💬 |
61 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PDE5A [1] PDE5A 💬 |
Udenafil Udenafil 💬 |
Udenafil | 086 [2] 86, 210 💬 💬 |
62 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
63 | MicroRNAs in cancer 💬 31 genes, 65 drugs (DrugBank) and 85 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
64 | Mineral absorption 💬 8 genes, 13 drugs (DrugBank) and 41 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
65 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRA1A [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
66 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
AVPR1A [3] AVPR1A, AVPR1B, AVPR2 💬 |
Vasopressin Vasopressin 💬 |
Vasopressin | 210 [1] 210 💬 💬 |
67 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
EDNRA [1] EDNRA 💬 |
Ambrisentan Ambrisentan 💬 |
Ambrisentan | 051 [7] 51, 84, 85, 86, 88, 210, 211 💬 💬 |
68 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
EDNRA [2] EDNRA, EDNRB 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
69 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
EDNRA [2] EDNRA, EDNRB 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
70 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
EDNRA [2] EDNRA, EDNRB 💬 |
Macitentan Macitentan 💬 |
Macitentan | 051 [5] 51, 85, 86, 88, 210 💬 💬 |
71 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
PTGIR [1] PTGIR 💬 |
Treprostinil Treprostinil 💬 |
Treprostinil | 051 [6] 51, 84, 85, 86, 88, 210 💬 💬 |
72 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
THRA [2] THRA, THRB 💬 |
Liothyronine Liothyronine 💬 |
Liothyronine | 013 [4] 13, 78, 210, 212 💬 💬 |
73 | NF-kappa B signaling pathway 💬 20 genes, 67 drugs (DrugBank) and 87 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
74 | Ovarian steroidogenesis 💬 7 genes, 36 drugs (DrugBank) and 52 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
75 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
76 | Pancreatic secretion 💬 13 genes, 35 drugs (DrugBank) and 36 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
77 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
78 | Pathogenic Escherichia coli infection 💬 26 genes, 39 drugs (DrugBank) and 74 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
79 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
EDNRA [1] EDNRA 💬 |
Ambrisentan Ambrisentan 💬 |
Ambrisentan | 051 [7] 51, 84, 85, 86, 88, 210, 211 💬 💬 |
80 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
EDNRA [2] EDNRA, EDNRB 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
81 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
EDNRA [2] EDNRA, EDNRB 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
82 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
EDNRA [2] EDNRA, EDNRB 💬 |
Macitentan Macitentan 💬 |
Macitentan | 051 [5] 51, 85, 86, 88, 210 💬 💬 |
83 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
84 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
85 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
86 | Phagosome 💬 13 genes, 10 drugs (DrugBank) and 21 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
87 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
AVPR1A [3] AVPR1A, AVPR1B, AVPR2 💬 |
Vasopressin Vasopressin 💬 |
Vasopressin | 210 [1] 210 💬 💬 |
88 | Platelet activation 💬 22 genes, 51 drugs (DrugBank) and 56 diseases |
PTGIR [1] PTGIR 💬 |
Treprostinil Treprostinil 💬 |
Treprostinil | 051 [6] 51, 84, 85, 86, 88, 210 💬 💬 |
89 | Platelet activation 💬 22 genes, 51 drugs (DrugBank) and 56 diseases |
PTGS1 [1] PTGS1 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
90 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
91 | Protein digestion and absorption 💬 7 genes, 7 drugs (DrugBank) and 13 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
92 | Proximal tubule bicarbonate reclamation 💬 6 genes, 6 drugs (DrugBank) and 19 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
93 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
PDE5A [1] PDE5A 💬 |
Sildenafil Sildenafil 💬 |
Sildenafil | 006 [17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 💬 |
94 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
PDE5A [1] PDE5A 💬 |
Tadalafil Tadalafil 💬 |
Tadalafil | 006 [7] 6 , 51, 75, 84, 86, 113, 210 💬 💬 |
95 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
PDE5A [1] PDE5A 💬 |
Udenafil Udenafil 💬 |
Udenafil | 086 [2] 86, 210 💬 💬 |
96 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
ADRB1 [2] ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
97 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
98 | Relaxin signaling pathway 💬 19 genes, 30 drugs (DrugBank) and 38 diseases |
EDNRB [1] EDNRB 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
99 | Relaxin signaling pathway 💬 19 genes, 30 drugs (DrugBank) and 38 diseases |
EDNRB [1] EDNRB 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
100 | Relaxin signaling pathway 💬 19 genes, 30 drugs (DrugBank) and 38 diseases |
EDNRB [1] EDNRB 💬 |
Macitentan Macitentan 💬 |
Macitentan | 051 [5] 51, 85, 86, 88, 210 💬 💬 |
101 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ACE [1] ACE 💬 |
Enalapril Enalapril 💬 |
Enalapril | 019 [6] 19, 46, 66, 113, 210, 222 💬 💬 |
102 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ADRB1 [2] ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
103 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
EDNRA [1] EDNRA 💬 |
Ambrisentan Ambrisentan 💬 |
Ambrisentan | 051 [7] 51, 84, 85, 86, 88, 210, 211 💬 💬 |
104 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
EDNRA [1] EDNRA 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
105 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
EDNRA [1] EDNRA 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
106 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
EDNRA [1] EDNRA 💬 |
Macitentan Macitentan 💬 |
Macitentan | 051 [5] 51, 85, 86, 88, 210 💬 💬 |
107 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
ACE [1] ACE 💬 |
Enalapril Enalapril 💬 |
Enalapril | 019 [6] 19, 46, 66, 113, 210, 222 💬 💬 |
108 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
109 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
ADRA1A [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
110 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
111 | Salmonella infection 💬 27 genes, 40 drugs (DrugBank) and 66 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
112 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
113 | Small cell lung cancer 💬 14 genes, 39 drugs (DrugBank) and 59 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
114 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
115 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
THRA [2] THRA, THRB 💬 |
Liothyronine Liothyronine 💬 |
Liothyronine | 013 [4] 13, 78, 210, 212 💬 💬 |
116 | Thyroid hormone synthesis 💬 7 genes, 6 drugs (DrugBank) and 7 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
117 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
118 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
ADRA1A [3] ADRA1A, ADRA1B, ADRA1D 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
119 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
AVPR1A [2] AVPR1A, AVPR1B 💬 |
Vasopressin Vasopressin 💬 |
Vasopressin | 210 [1] 210 💬 💬 |
120 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
EDNRA [1] EDNRA 💬 |
Ambrisentan Ambrisentan 💬 |
Ambrisentan | 051 [7] 51, 84, 85, 86, 88, 210, 211 💬 💬 |
121 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
EDNRA [1] EDNRA 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
122 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
EDNRA [1] EDNRA 💬 |
Bosentan Bosentan 💬 |
Bosentan | 041 [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬 |
123 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
EDNRA [1] EDNRA 💬 |
Macitentan Macitentan 💬 |
Macitentan | 051 [5] 51, 85, 86, 88, 210 💬 💬 |
124 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
PTGIR [1] PTGIR 💬 |
Treprostinil Treprostinil 💬 |
Treprostinil | 051 [6] 51, 84, 85, 86, 88, 210 💬 💬 |
125 | Vasopressin-regulated water reabsorption 💬 1 gene, 6 drugs (DrugBank) and 10 diseases |
AVPR2 [1] AVPR2 💬 |
Vasopressin Vasopressin 💬 |
Vasopressin | 210 [1] 210 💬 💬 |
126 | VEGF signaling pathway 💬 21 genes, 53 drugs (DrugBank) and 90 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |