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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Adrenergic signaling in cardiomyocytes 💬

[5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬

Carvedilol 💬

Carvedilol

[4] 57, 86, 113, 210 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
86	Pulmonary arterial hypertension;PAH;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Adrenergic signaling in cardiomyocytes 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

Digoxin 💬

Digoxin

[3] 8 , 46, 210 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Aldosterone synthesis and secretion 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

Digoxin 💬

Digoxin

[3] 8 , 46, 210 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Aldosterone-regulated sodium reabsorption 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

Digoxin 💬

Digoxin

[3] 8 , 46, 210 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Aldosterone-regulated sodium reabsorption 💬

[1] NR3C2 💬

Eplerenone 💬

Eplerenone

[4] 75, 113, 210, 215 💬

Disease ID	Name
75	Cushing disease;Cushing;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
215	Tetralogy of Fallot;Fallot tetralogy;

Aldosterone-regulated sodium reabsorption 💬

[1] NR3C2 💬

Spironolactone 💬

Spironolactone

[8] 46, 58, 67, 86, 113, 210, 218, 225 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
58	Hypertrophic cardiomyopathy;HCM;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
86	Pulmonary arterial hypertension;PAH;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;

Alzheimer disease 💬

[1] PTGS2 💬

Aspirin 💬

Acetylsalicylic acid

[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
22	Moyamoya disease;Occlusive disease in circle of Willis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
64	Thrombotic thrombocytopenic purpura;TTP;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
158	Tuberous sclerosis;Tuberous sclerosis complex;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
231	Alpha-1-antitrypsin deficiency;AATD;
251	Urea cycle disorder;

Alzheimer disease 💬

[9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬

Name	Full Name
TUBB	tubulin beta class I
TUBB1	tubulin beta 1 class VI
TUBB2A	tubulin beta 2A class IIa
TUBB2B	tubulin beta 2B class IIb
TUBB3	tubulin beta 3 class III
TUBB4A	tubulin beta 4A class IVa
TUBB4B	tubulin beta 4B class IVb
TUBB6	tubulin beta 6 class V
TUBB8	tubulin beta 8 class VIII

Colchicine 💬

Colchicine

[7] 2 , 42, 46, 56, 93, 210, 266 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
42	Polyarteritis nodosa;PAN;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
56	Behcet disease;Behçet disease;BD;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
266	Familial mediterranean fever;

AMPK signaling pathway 💬

[1] ADRA1A 💬

Carvedilol 💬

Carvedilol

[4] 57, 86, 113, 210 💬

Disease ID	Name
57	Idiopathic dilated cardiomyopathy;
86	Pulmonary arterial hypertension;PAH;
113	Muscular dystrophy;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Amyotrophic lateral sclerosis 💬

[9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬

Name	Full Name
TUBB	tubulin beta class I
TUBB1	tubulin beta 1 class VI
TUBB2A	tubulin beta 2A class IIa
TUBB2B	tubulin beta 2B class IIb
TUBB3	tubulin beta 3 class III
TUBB4A	tubulin beta 4A class IVa
TUBB4B	tubulin beta 4B class IVb
TUBB6	tubulin beta 6 class V
TUBB8	tubulin beta 8 class VIII

Colchicine 💬

Colchicine

[7] 2 , 42, 46, 56, 93, 210, 266 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
42	Polyarteritis nodosa;PAN;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
56	Behcet disease;Behçet disease;BD;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
266	Familial mediterranean fever;

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