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No.	KEGG PATHWAY	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Chagas disease 💬	[1] ACE 💬	Benazepril 💬	Benazepril	[4] 49, 57, 218, 224 💬 💬
2	Chagas disease 💬	[1] ACE 💬	Captopril 💬	Captopril	[8] 6 , 17, 46, 86, 96, 97, 107, 271 💬 💬
3	Chagas disease 💬	[1] ACE 💬	Cilazapril 💬	Cilazapril	[1] 66 💬 💬
4	Chagas disease 💬	[1] ACE 💬	Cilazapril 💬	Cilazapril	[1] 66 💬 💬
5	Chagas disease 💬	[1] ACE 💬	Enalapril 💬	Enalapril	[6] 19, 46, 66, 113, 210, 222 💬 💬
6	Chagas disease 💬	[1] ACE 💬	Imidapril 💬	Imidapril	[1] 67 💬 💬
7	Chagas disease 💬	[1] ACE 💬	Lisinopril 💬	Lisinopril	[7] 19, 46, 49, 66, 67, 113, 222 💬 💬
8	Chagas disease 💬	[1] ACE 💬	Lisinopril 💬	Lisinopril	[7] 19, 46, 49, 66, 67, 113, 222 💬 💬
9	Chagas disease 💬	[1] ACE 💬	Moexipril 💬	Moexipril	[1] 93 💬 💬
10	Chagas disease 💬	[1] ACE 💬	Perindopril 💬	Perindopril	[4] 58, 113, 167, 222 💬 💬
11	Chagas disease 💬	[1] ACE 💬	Quinapril 💬	Quinapril	[1] 19 💬 💬
12	Chagas disease 💬	[1] ACE 💬	Ramipril 💬	Ramipril	[7] 46, 49, 66, 67, 113, 218, 257 💬 💬
13	Chagas disease 💬	[1] C3 💬	Pegcetacoplan 💬	Pegcetacoplan	[4] 2 , 61, 62, 222 💬 💬
14	Chagas disease 💬	[5] CCL2, IL10, IL1B, IL6, TNF 💬	Pirfenidone 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬
15	Chagas disease 💬	[3] CD3D, CD3E, CD3G 💬	Otelixizumab 💬	Otelixizumab	[1] 46 💬 💬
16	Chagas disease 💬	[3] CD3D, CD3E, CD3G 💬	Visilizumab 💬	Visilizumab	[2] 96, 97 💬 💬
17	Chagas disease 💬	[1] CD3E 💬	Mosunetuzumab 💬	Mosunetuzumab	[1] 49 💬 💬
18	Chagas disease 💬	[1] IFNG 💬	Emapalumab 💬	Emapalumab	[3] 49, 65, 107 💬 💬
19	Chagas disease 💬	[1] IFNG 💬	Fontolizumab 💬	Fontolizumab	[1] 46 💬 💬
20	Chagas disease 💬	[2] IFNGR1, IFNGR2 💬	Interferon gamma-1b 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬 💬
21	Chagas disease 💬	[2] IL12A, IL12B 💬	Ustekinumab 💬	Ustekinumab	[16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬 💬
22	Chagas disease 💬	[1] IL1B 💬	Canakinumab 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬
23	Chagas disease 💬	[1] IL1B 💬	Gevokizumab 💬	Gevokizumab	[4] 41, 50, 56, 269 💬 💬
24	Chagas disease 💬	[1] IL1B 💬	Rilonacept 💬	Rilonacept	[4] 51, 106, 107, 266 💬 💬
25	Chagas disease 💬	[1] IL6 💬	Olokizumab 💬	Olokizumab	[2] 46, 96 💬 💬
26	Chagas disease 💬	[1] IL6 💬	Siltuximab 💬	Siltuximab	[2] 28, 331 💬 💬
27	Chagas disease 💬	[1] IL6 💬	Sirukumab 💬	Sirukumab	[2] 41, 46 💬 💬
28	Chagas disease 💬	[2] IL6, TNF 💬	Pomalidomide 💬	Pomalidomide	[5] 28, 51, 85, 227, 331 💬 💬
29	Chagas disease 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	Losmapimod 💬	Losmapimod	[2] 113, 222 💬 💬
30	Chagas disease 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	Neflamapimod 💬	Neflamapimod	[1] 8 💬 💬
31	Chagas disease 💬	[1] NFKB1 💬	Iguratimod 💬	Iguratimod	[5] 46, 51, 53, 271, 300 💬 💬
32	Chagas disease 💬	[1] PIK3CA 💬	Alpelisib 💬	Alpelisib	[1] 138 💬 💬
33	Chagas disease 💬	[3] PIK3CA, PIK3CB, PIK3CD 💬	Leniolisib 💬	Leniolisib	[2] 53, 65 💬 💬
34	Chagas disease 💬	[1] PIK3CD 💬	Parsaclisib 💬	Parsaclisib	[3] 35, 53, 61 💬 💬
35	Chagas disease 💬	[1] RELA 💬	Edasalonexent 💬	Edasalonexent	[1] 113 💬 💬
36	Chagas disease 💬	[3] TGFB1, TGFB2, TGFB3 💬	Fresolimumab 💬	Fresolimumab	[3] 51, 85, 222 💬 💬
37	Chagas disease 💬	[1] TLR9 💬	Cobitolimod 💬	Cobitolimod	[1] 97 💬 💬
38	Chagas disease 💬	[1] TNF 💬	Adalimumab 💬	Adalimumab	[17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬
39	Chagas disease 💬	[1] TNF 💬	Certolizumab pegol 💬	Certolizumab pegol	[8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬
40	Chagas disease 💬	[1] TNF 💬	Etanercept 💬	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬
41	Chagas disease 💬	[1] TNF 💬	Golimumab 💬	Golimumab	[8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬
42	Chagas disease 💬	[1] TNF 💬	Infliximab 💬	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬
43	Chagas disease 💬	[1] TNF 💬	Lenalidomide 💬	Lenalidomide	[8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬
44	Chagas disease 💬	[1] TNF 💬	Ozoralizumab 💬	Ozoralizumab	[1] 46 💬 💬
45	Chagas disease 💬	[1] TNF 💬	Pegsunercept 💬	Pegsunercept	[1] 46 💬 💬
46	Chagas disease 💬	[1] TNF 💬	Thalidomide 💬	Thalidomide	[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬