Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Neutrophil extracellular trap formation 💬

[1] C3 💬

Pegcetacoplan 💬

[4] 2 , 61, 62, 222 💬

2

Neutrophil extracellular trap formation 💬

[1] C5 💬

Crovalimab 💬

[2] 62, 109 💬

3

Neutrophil extracellular trap formation 💬

[1] C5 💬

Eculizumab 💬

[7] 11, 13, 14, 61, 62, 109, 222 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
109	Atypical hemolytic uremic syndrome;aHUS;
222	Primary nephrotic syndrome;

4

Neutrophil extracellular trap formation 💬

[1] C5 💬

[3] 62, 109, 162 💬

5

Neutrophil extracellular trap formation 💬

[1] C5 💬

[2] 11, 62 💬

6

Neutrophil extracellular trap formation 💬

[1] C5 💬

Ravulizumab 💬

[7] 2 , 11, 13, 50, 62, 66, 109 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
50	Dermatomyositis;Polymyositis;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
109	Atypical hemolytic uremic syndrome;aHUS;

7

Neutrophil extracellular trap formation 💬

[1] C5 💬

Vilobelimab 💬

[3] 43, 44, 269 💬

Disease ID	Name
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;

8

Neutrophil extracellular trap formation 💬

[1] C5 💬

Zilucoplan 💬

[3] 2 , 11, 62 💬

9

Neutrophil extracellular trap formation 💬

[1] C5AR1 💬

[3] 43, 44, 222 💬

10

Neutrophil extracellular trap formation 💬

[1] ELANE 💬

Sivelestat 💬

[3] 13, 85, 96 💬

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