Target Gene/Pathway Pathway / Gene
Search results
No. | KEGG PATHWAY | KEGG GENES | KEGG DRUG | DrugBank | Disease ID |
---|---|---|---|---|---|
1 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
2 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
SLC6A3 [1] SLC6A3 💬 |
Bupropion Bupropion 💬 |
Bupropion | 008 [5] 8 , 18, 21, 96, 171 💬 💬 |
3 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
4 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
GRIA1 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
5 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
SLC6A3 [1] SLC6A3 💬 |
Bupropion Bupropion 💬 |
Bupropion | 008 [5] 8 , 18, 21, 96, 171 💬 💬 |
6 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
HMGCR [1] HMGCR 💬 |
Rosuvastatin Rosuvastatin 💬 |
Rosuvastatin | 006 [11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬 💬 |
7 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
GRIA1 [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
8 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
HMGCR [1] HMGCR 💬 |
Rosuvastatin Rosuvastatin 💬 |
Rosuvastatin | 006 [11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬 💬 |
9 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
GRIN1 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
10 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
11 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
GRIA1 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
12 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
13 | Chemical carcinogenesis - reactive oxygen species 💬 25 genes, 37 drugs (DrugBank) and 42 diseases |
NFE2L2 [1] NFE2L2 💬 |
Omaveloxolone Omaveloxolone 💬 |
Omaveloxolone | 018 [1] 18 💬 💬 |
14 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
CHRNA4 [2] CHRNA4, CHRNB2 💬 |
Varenicline Varenicline 💬 |
Varenicline | 006 [3] 6 , 18, 53 💬 💬 |
15 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
VDR [1] VDR 💬 |
Calcitriol Calcitriol 💬 |
Calcitriol | 018 [9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬 💬 |
16 | Cholinergic synapse 💬 32 genes, 48 drugs (DrugBank) and 59 diseases |
CHRNA4 [2] CHRNA4, CHRNB2 💬 |
Varenicline Varenicline 💬 |
Varenicline | 006 [3] 6 , 18, 53 💬 💬 |
17 | Circadian entrainment 💬 22 genes, 32 drugs (DrugBank) and 55 diseases |
GRIA1 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
18 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
GRIA2 [6] GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
19 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
SLC6A3 [1] SLC6A3 💬 |
Bupropion Bupropion 💬 |
Bupropion | 008 [5] 8 , 18, 21, 96, 171 💬 💬 |
20 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
CSF3R [1] CSF3R 💬 |
Lenograstim Lenograstim 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 💬 |
21 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
22 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
GRIA1 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
23 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
SLC6A3 [1] SLC6A3 💬 |
Bupropion Bupropion 💬 |
Bupropion | 008 [5] 8 , 18, 21, 96, 171 💬 💬 |
24 | Endocrine and other factor-regulated calcium reabsorption 💬 8 genes, 27 drugs (DrugBank) and 55 diseases |
VDR [1] VDR 💬 |
Calcitriol Calcitriol 💬 |
Calcitriol | 018 [9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬 💬 |
25 | Estrogen signaling pathway 💬 19 genes, 74 drugs (DrugBank) and 64 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
26 | Fluid shear stress and atherosclerosis 💬 29 genes, 48 drugs (DrugBank) and 86 diseases |
NFE2L2 [1] NFE2L2 💬 |
Omaveloxolone Omaveloxolone 💬 |
Omaveloxolone | 018 [1] 18 💬 💬 |
27 | GABAergic synapse 💬 29 genes, 38 drugs (DrugBank) and 55 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
28 | GABAergic synapse 💬 29 genes, 38 drugs (DrugBank) and 55 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Flumazenil Flumazenil 💬 |
Flumazenil | 006 [5] 6 , 13, 17, 18, 206 💬 💬 |
29 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
GRIA1 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
30 | GnRH secretion 💬 20 genes, 42 drugs (DrugBank) and 54 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
31 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
CSF3R [1] CSF3R 💬 |
Lenograstim Lenograstim 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 💬 |
32 | Hepatocellular carcinoma 💬 21 genes, 31 drugs (DrugBank) and 57 diseases |
NFE2L2 [1] NFE2L2 💬 |
Omaveloxolone Omaveloxolone 💬 |
Omaveloxolone | 018 [1] 18 💬 💬 |
33 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
34 | HIF-1 signaling pathway 💬 23 genes, 48 drugs (DrugBank) and 76 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
35 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
GRIA1 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2B 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
36 | Inflammatory bowel disease 💬 24 genes, 43 drugs (DrugBank) and 64 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
37 | Influenza A 💬 45 genes, 63 drugs (DrugBank) and 85 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
38 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
CSF3R [1] CSF3R 💬 |
Lenograstim Lenograstim 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 💬 |
39 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
40 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
IFNGR1 [1] IFNGR1 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
41 | Leishmaniasis 💬 25 genes, 63 drugs (DrugBank) and 93 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
42 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
NFE2L2 [1] NFE2L2 💬 |
Omaveloxolone Omaveloxolone 💬 |
Omaveloxolone | 018 [1] 18 💬 💬 |
43 | Long-term depression 💬 13 genes, 19 drugs (DrugBank) and 32 diseases |
GRIA1 [3] GRIA1, GRIA2, GRIA3 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
44 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
GRIA1 [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
45 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
HMGCR [1] HMGCR 💬 |
Rosuvastatin Rosuvastatin 💬 |
Rosuvastatin | 006 [11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬 💬 |
46 | Mineral absorption 💬 8 genes, 13 drugs (DrugBank) and 41 diseases |
VDR [1] VDR 💬 |
Calcitriol Calcitriol 💬 |
Calcitriol | 018 [9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬 💬 |
47 | Morphine addiction 💬 41 genes, 65 drugs (DrugBank) and 73 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
48 | Morphine addiction 💬 41 genes, 65 drugs (DrugBank) and 73 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Flumazenil Flumazenil 💬 |
Flumazenil | 006 [5] 6 , 13, 17, 18, 206 💬 💬 |
49 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
50 | Necroptosis 💬 28 genes, 39 drugs (DrugBank) and 68 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
51 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
CHRNA4 [2] CHRNA4, CHRNB2 💬 |
Varenicline Varenicline 💬 |
Varenicline | 006 [3] 6 , 18, 53 💬 💬 |
52 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
53 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Flumazenil Flumazenil 💬 |
Flumazenil | 006 [5] 6 , 13, 17, 18, 206 💬 💬 |
54 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GRIA1 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
55 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Methylprednisolone Methylprednisolone 💬 |
Methylprednisolone | 002 [46] 2 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬 💬 |
56 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
CHRNA4 [2] CHRNA4, CHRNB2 💬 |
Varenicline Varenicline 💬 |
Varenicline | 006 [3] 6 , 18, 53 💬 💬 |
57 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Flumazenil Flumazenil 💬 |
Flumazenil | 006 [5] 6 , 13, 17, 18, 206 💬 💬 |
58 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
GRIA1 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
59 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
60 | Parathyroid hormone synthesis, secretion and action 💬 21 genes, 48 drugs (DrugBank) and 65 diseases |
VDR [1] VDR 💬 |
Calcitriol Calcitriol 💬 |
Calcitriol | 018 [9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬 💬 |
61 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
NFE2L2 [1] NFE2L2 💬 |
Omaveloxolone Omaveloxolone 💬 |
Omaveloxolone | 018 [1] 18 💬 💬 |
62 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
SLC6A3 [1] SLC6A3 💬 |
Bupropion Bupropion 💬 |
Bupropion | 008 [5] 8 , 18, 21, 96, 171 💬 💬 |
63 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
CSF3R [1] CSF3R 💬 |
Lenograstim Lenograstim 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 💬 |
64 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
65 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
NFE2L2 [1] NFE2L2 💬 |
Omaveloxolone Omaveloxolone 💬 |
Omaveloxolone | 018 [1] 18 💬 💬 |
66 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
GRIA1 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
67 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
SLC6A3 [1] SLC6A3 💬 |
Bupropion Bupropion 💬 |
Bupropion | 008 [5] 8 , 18, 21, 96, 171 💬 💬 |
68 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
69 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
CSF3R [1] CSF3R 💬 |
Lenograstim Lenograstim 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 💬 |
70 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
71 | Protein processing in endoplasmic reticulum 💬 3 genes, 3 drugs (DrugBank) and 3 diseases |
NFE2L2 [1] NFE2L2 💬 |
Omaveloxolone Omaveloxolone 💬 |
Omaveloxolone | 018 [1] 18 💬 💬 |
72 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
GRIN1 [3] GRIN1, GRIN2A, GRIN2B 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
73 | Ras signaling pathway 💬 35 genes, 53 drugs (DrugBank) and 62 diseases |
GRIN1 [3] GRIN1, GRIN2A, GRIN2B 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
74 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Flumazenil Flumazenil 💬 |
Flumazenil | 006 [5] 6 , 13, 17, 18, 206 💬 💬 |
75 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
76 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
GABRB1 [3] GABRB1, GABRB2, GABRB3 💬 |
Flumazenil Flumazenil 💬 |
Flumazenil | 006 [5] 6 , 13, 17, 18, 206 💬 💬 |
77 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
SLC6A4 [1] SLC6A4 💬 |
Citalopram Citalopram 💬 |
Citalopram | 006 [7] 6 , 8 , 13, 18, 46, 98, 127 💬 💬 |
78 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIA1 [3] GRIA1, GRIA2, GRIA3 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
79 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIA1 [3] GRIA1, GRIA2, GRIA3 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
80 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIA1 [3] GRIA1, GRIA2, GRIA3 💬 |
Topiramate Topiramate 💬 |
Topiramate | 006 [6] 6 , 97, 140, 144, 156, 193 💬 💬 |
81 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIA1 [8] GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
82 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Acamprosate Acamprosate 💬 |
Acamprosate | 006 [2] 6 , 206 💬 💬 |
83 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Amantadine Amantadine 💬 |
Amantadine | 006 [4] 6 , 8 , 13, 127 💬 💬 |
84 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
85 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
86 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
87 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Latrepirdine Latrepirdine 💬 |
Latrepirdine | 008 [1] 8 💬 💬 |
88 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
89 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
KCNC3 [2] KCNC3, KCND3 💬 |
Amifampridine Amifampridine 💬 |
Amifampridine | 003 [3] 3 , 11, 12 💬 💬 |
90 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
KCNC3 [2] KCNC3, KCND3 💬 |
Dalfampridine Dalfampridine 💬 |
Dalfampridine | 003 [5] 3 , 4 , 6 , 13, 14 💬 💬 |
91 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
KCND3 [1] KCND3 💬 |
Amiodarone Amiodarone 💬 |
Amiodarone | 028 [2] 28, 127 💬 💬 |
92 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
MAP3K5 [1] MAP3K5 💬 |
Selonsertib Selonsertib 💬 |
Selonsertib | 086 [1] 86 💬 💬 |
93 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
MTOR [1] MTOR 💬 |
Everolimus Everolimus 💬 |
Everolimus | 034 [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 💬 |
94 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
95 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
MTOR [1] MTOR 💬 |
Temsirolimus Temsirolimus 💬 |
Temsirolimus | 013 [1] 13 💬 💬 |
96 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
PIK3CA [1] PIK3CA 💬 |
Alpelisib Alpelisib 💬 |
Alpelisib | 138 [1] 138 💬 💬 |
97 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
PIK3CA [3] PIK3CA, PIK3CB, PIK3CD 💬 |
Leniolisib Leniolisib 💬 |
Leniolisib | 053 [2] 53, 65 💬 💬 |
98 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
PIK3CD [1] PIK3CD 💬 |
Parsaclisib Parsaclisib 💬 |
Parsaclisib | 035 [3] 35, 53, 61 💬 💬 |
99 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
PRKCB [1] PRKCB 💬 |
Enzastaurin Enzastaurin 💬 |
Enzastaurin | 168 [1] 168 💬 💬 |
100 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
PSMB5 [1] PSMB5 💬 |
Bortezomib Bortezomib 💬 |
Bortezomib | 011 [17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 💬 |
101 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
PSMB5 [1] PSMB5 💬 |
Carfilzomib Carfilzomib 💬 |
Carfilzomib | 028 [1] 28 💬 💬 |
102 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
PSMB5 [1] PSMB5 💬 |
Ixazomib Ixazomib 💬 |
Ixazomib | 013 [5] 13, 16, 28, 51, 61 💬 💬 |
103 | Synaptic vesicle cycle 💬 7 genes, 30 drugs (DrugBank) and 40 diseases |
SLC6A2 [2] SLC6A2, SLC6A3 💬 |
Bupropion Bupropion 💬 |
Bupropion | 008 [5] 8 , 18, 21, 96, 171 💬 💬 |
104 | Synaptic vesicle cycle 💬 7 genes, 30 drugs (DrugBank) and 40 diseases |
SLC6A4 [1] SLC6A4 💬 |
Citalopram Citalopram 💬 |
Citalopram | 006 [7] 6 , 8 , 13, 18, 46, 98, 127 💬 💬 |
105 | Systemic lupus erythematosus 💬 14 genes, 38 drugs (DrugBank) and 78 diseases |
GRIN2A [2] GRIN2A, GRIN2B 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
106 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
107 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Flumazenil Flumazenil 💬 |
Flumazenil | 006 [5] 6 , 13, 17, 18, 206 💬 💬 |
108 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
HMGCR [1] HMGCR 💬 |
Rosuvastatin Rosuvastatin 💬 |
Rosuvastatin | 006 [11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬 💬 |
109 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
110 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
111 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
112 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
GRIA3 [1] GRIA3 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
113 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
114 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
VDR [1] VDR 💬 |
Calcitriol Calcitriol 💬 |
Calcitriol | 018 [9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬 💬 |