Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 Breast cancer 💬
[2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
2 Breast cancer 💬
[2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
3 Breast cancer 💬
[2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
4 Breast cancer 💬
[2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
5 Breast cancer 💬
[2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
6 Breast cancer 💬
[2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
7 Breast cancer 💬
[2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
8 Breast cancer 💬
[2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
9 Breast cancer 💬
[2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
10 Breast cancer 💬
[2] ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
11 Breast cancer 💬
[2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
12 Breast cancer 💬
[2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
13 Chemical carcinogenesis - receptor activation 💬
[3] AR, ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
14 Chemical carcinogenesis - receptor activation 💬
[2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
15 Chemical carcinogenesis - receptor activation 💬
[2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
16 Chemical carcinogenesis - receptor activation 💬
[2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
17 Chemical carcinogenesis - receptor activation 💬
[2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
18 Chemical carcinogenesis - receptor activation 💬
[2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
19 Chemical carcinogenesis - receptor activation 💬
[2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
20 Chemical carcinogenesis - receptor activation 💬
[2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
21 Chemical carcinogenesis - receptor activation 💬
[2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
22 Chemical carcinogenesis - receptor activation 💬
[2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
23 Chemical carcinogenesis - receptor activation 💬
[2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
24 Chemical carcinogenesis - receptor activation 💬
[2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
25 Endocrine resistance 💬
[2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
26 Endocrine resistance 💬
[2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
27 Endocrine resistance 💬
[2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
28 Endocrine resistance 💬
[2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
29 Endocrine resistance 💬
[2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
30 Endocrine resistance 💬
[2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
31 Endocrine resistance 💬
[2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
32 Endocrine resistance 💬
[2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
33 Endocrine resistance 💬
[2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
34 Endocrine resistance 💬
[2] ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
35 Endocrine resistance 💬
[2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
36 Endocrine resistance 💬
[2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
37 Estrogen signaling pathway 💬
[2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
38 Estrogen signaling pathway 💬
[2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
39 Estrogen signaling pathway 💬
[2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
40 Estrogen signaling pathway 💬
[2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
41 Estrogen signaling pathway 💬
[2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
42 Estrogen signaling pathway 💬
[2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
43 Estrogen signaling pathway 💬
[2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
44 Estrogen signaling pathway 💬
[2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
45 Estrogen signaling pathway 💬
[2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
46 Estrogen signaling pathway 💬
[2] ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
47 Estrogen signaling pathway 💬
[2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
48 Estrogen signaling pathway 💬
[2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
49 GnRH secretion 💬
[1] ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
50 GnRH secretion 💬
[1] ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
51 GnRH secretion 💬
[1] ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
52 GnRH secretion 💬
[1] ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
53 GnRH secretion 💬
[1] ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
54 GnRH secretion 💬
[1] ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
55 GnRH secretion 💬
[1] ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
56 GnRH secretion 💬
[1] ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
57 GnRH secretion 💬
[1] ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
58 GnRH secretion 💬
[1] ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
59 GnRH secretion 💬
[1] ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
60 GnRH secretion 💬
[1] ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
61 Pathways in cancer 💬
[3] AR, ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
62 Pathways in cancer 💬
[2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
63 Pathways in cancer 💬
[2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
64 Pathways in cancer 💬
[2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
65 Pathways in cancer 💬
[2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
66 Pathways in cancer 💬
[2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
67 Pathways in cancer 💬
[2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
68 Pathways in cancer 💬
[2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
69 Pathways in cancer 💬
[2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
70 Pathways in cancer 💬
[2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
71 Pathways in cancer 💬
[2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
72 Pathways in cancer 💬
[2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
73 Prolactin signaling pathway 💬
[2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
74 Prolactin signaling pathway 💬
[2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
75 Prolactin signaling pathway 💬
[2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
76 Prolactin signaling pathway 💬
[2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
77 Prolactin signaling pathway 💬
[2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
78 Prolactin signaling pathway 💬
[2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
79 Prolactin signaling pathway 💬
[2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
80 Prolactin signaling pathway 💬
[2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
81 Prolactin signaling pathway 💬
[2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
82 Prolactin signaling pathway 💬
[2] ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
83 Prolactin signaling pathway 💬
[2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
84 Prolactin signaling pathway 💬
[2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬