Target Gene/Pathway Pathway / Gene

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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Calcium signaling pathway 💬

[1] ADORA2A 💬

Istradefylline 💬

[1] 6 💬

2

Calcium signaling pathway 💬

[1] ADORA2A 💬

Preladenant 💬

[1] 6 💬

3

Calcium signaling pathway 💬

[1] ADORA2A 💬

Regadenoson 💬

[1] 58 💬

4

Calcium signaling pathway 💬

[1] ADORA2A 💬

Regadenoson 💬

[1] 58 💬

5

Calcium signaling pathway 💬

[1] ADORA2A 💬

Tozadenant 💬

[1] 6 💬

6

Calcium signaling pathway 💬

[2] ADORA2A, ADORA2B 💬

[3] 13, 58, 65 💬

7

Calcium signaling pathway 💬

[2] ADORA2A, ADORA2B 💬

Adenosine phosphate 💬

Adenosine phosphate

[1] 46 💬

8

Calcium signaling pathway 💬

[2] ADORA2A, PDE1B 💬

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

9

Calcium signaling pathway 💬

[2] ADORA2A, PDE1B 💬

Caffeine hydrate 💬

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

10

Calcium signaling pathway 💬

[4] ADORA2B, PDE1A, PDE1B, PDE1C 💬

Aminophylline 💬

[1] 63 💬

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