Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

[1] BCL2 💬

Venetoclax 💬

[1] 28 💬

2

[1] CASP9 💬

[6] 19, 60, 65, 284, 285, 326 💬

3

[1] CTSC 💬

Brensocatib 💬

[1] 299 💬

4

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

[1] 34 💬

5

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

[1] 280 💬

6

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

[1] 34 💬

7

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

[1] 34 💬

8

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

9

[1] MAP3K5 💬

Selonsertib 💬

[1] 86 💬

10

[1] NFKB1 💬

Iguratimod 💬

[5] 46, 51, 53, 271, 300 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;

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