Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY KEGG GENES KEGG DRUG DrugBank Disease ID
1 Osteoclast differentiation 💬
 [1] BTK 💬 Acalabrutinib 💬 Acalabrutinib [2] 46, 61 💬 💬
2 Osteoclast differentiation 💬
 [1] BTK 💬 Branebrutinib 💬 Branebrutinib [3] 46, 49, 53 💬 💬
3 Osteoclast differentiation 💬
 [1] BTK 💬 Evobrutinib 💬 Evobrutinib [3] 13, 46, 49 💬 💬
4 Osteoclast differentiation 💬
 [1] BTK 💬 Fenebrutinib 💬 Fenebrutinib [1] 13 💬 💬
5 Osteoclast differentiation 💬
 [1] BTK 💬 Ibrutinib 💬 Ibrutinib [3] 28, 60, 61 💬 💬
6 Osteoclast differentiation 💬
 [1] BTK 💬 Orelabrutinib 💬 Orelabrutinib [4] 13, 49, 61, 63 💬 💬
7 Osteoclast differentiation 💬
 [1] BTK 💬 Remibrutinib 💬 Remibrutinib [2] 13, 53 💬 💬
8 Osteoclast differentiation 💬
 [1] BTK 💬 Zanubrutinib 💬 Zanubrutinib [5] 13, 63, 222, 300, 331 💬 💬
9 Osteoclast differentiation 💬
 [1] CSF1R 💬 Pexidartinib 💬 Pexidartinib [1] 34 💬 💬
10 Osteoclast differentiation 💬
 [1] CSF1R 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬 💬
11 Osteoclast differentiation 💬
 [2] FYN, LCK 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬 💬
12 Osteoclast differentiation 💬
 [2] FYN, LCK 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬 💬
13 Osteoclast differentiation 💬
 [2] IFNAR1, IFNAR2 💬 Anifrolumab 💬 Anifrolumab [3] 46, 49, 53 💬 💬
14 Osteoclast differentiation 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa 💬 Interferon alfa [6] 13, 25, 26, 28, 56, 96 💬 💬
15 Osteoclast differentiation 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa-2a 💬 Interferon alfa-2a [1] 56 💬 💬
16 Osteoclast differentiation 💬
 [2] IFNAR1, IFNAR2 💬 Interferon alfa-2b 💬 Interferon alfa-2b [2] 25, 34 💬 💬
17 Osteoclast differentiation 💬
 [2] IFNAR1, IFNAR2 💬 Interferon beta-1a 💬 Interferon beta-1a [4] 13, 26, 96, 97 💬 💬
18 Osteoclast differentiation 💬
 [2] IFNAR1, IFNAR2 💬 Interferon beta-1b 💬 Interferon beta-1b [1] 13 💬 💬
19 Osteoclast differentiation 💬
 [2] IFNAR1, IFNAR2 💬 Peginterferon beta-1a 💬 Peginterferon beta-1a [1] 13 💬 💬
20 Osteoclast differentiation 💬
 [1] IFNG 💬 Emapalumab 💬 Emapalumab [3] 49, 65, 107 💬 💬
21 Osteoclast differentiation 💬
 [1] IFNG 💬 Fontolizumab 💬 Fontolizumab [1] 46 💬 💬
22 Osteoclast differentiation 💬
 [2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬 💬
23 Osteoclast differentiation 💬
 [1] IL1A 💬 Bermekimab 💬 Bermekimab [1] 51 💬 💬
24 Osteoclast differentiation 💬
 [2] IL1A, IL1B 💬 Rilonacept 💬 Rilonacept [4] 51, 106, 107, 266 💬 💬
25 Osteoclast differentiation 💬
 [3] IL1A, IL1B, TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬
26 Osteoclast differentiation 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬
27 Osteoclast differentiation 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬 💬
28 Osteoclast differentiation 💬
 [1] IL1R1 💬 Anakinra 💬 Anakinra [18]  2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬
29 Osteoclast differentiation 💬
 [1] JAK1 💬 Abrocitinib 💬 Abrocitinib [1] 84 💬 💬
30 Osteoclast differentiation 💬
 [1] JAK1 💬 Baricitinib 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬
31 Osteoclast differentiation 💬
 [1] JAK1 💬 Filgotinib 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬 💬
32 Osteoclast differentiation 💬
 [1] JAK1 💬 Itacitinib 💬 Itacitinib [4] 46, 51, 97, 228 💬 💬
33 Osteoclast differentiation 💬
 [1] JAK1 💬 Peficitinib 💬 Peficitinib [1] 46 💬 💬
34 Osteoclast differentiation 💬
 [1] JAK1 💬 Ruxolitinib 💬 Ruxolitinib [3] 60, 65, 228 💬 💬
35 Osteoclast differentiation 💬
 [1] JAK1 💬 Upadacitinib 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬 💬
36 Osteoclast differentiation 💬
 [2] JAK1, TYK2 💬 Tofacitinib 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬 💬
37 Osteoclast differentiation 💬
 [1] LILRA4 💬 Daxdilimab 💬 Daxdilimab [2] 49, 50 💬 💬
38 Osteoclast differentiation 💬
 [1] MAP2K1 💬 Binimetinib 💬 Binimetinib [1] 34 💬 💬
39 Osteoclast differentiation 💬
 [1] MAP2K1 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬 💬
40 Osteoclast differentiation 💬
 [1] MAP2K1 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬 💬
41 Osteoclast differentiation 💬
 [1] MAP2K1 💬 Selumetinib 💬 Selumetinib [1] 34 💬 💬
42 Osteoclast differentiation 💬
 [1] MAP2K1 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬 💬
43 Osteoclast differentiation 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬 💬
44 Osteoclast differentiation 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬 💬
45 Osteoclast differentiation 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬 💬
46 Osteoclast differentiation 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬 💬
47 Osteoclast differentiation 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬 💬
48 Osteoclast differentiation 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬 💬
49 Osteoclast differentiation 💬
 [1] PPARG 💬 Bocidelpar 💬 Bocidelpar [1] 113 💬 💬
50 Osteoclast differentiation 💬
 [1] PPARG 💬 Leriglitazone 💬 Leriglitazone [1] 20 💬 💬
51 Osteoclast differentiation 💬
 [1] PPARG 💬 Pioglitazone 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬
52 Osteoclast differentiation 💬
 [1] PPARG 💬 Rosiglitazone 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬 💬
53 Osteoclast differentiation 💬
 [1] PPARG 💬 Seladelpar 💬 Seladelpar [2] 93, 94 💬 💬
54 Osteoclast differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cyclosporine 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬
55 Osteoclast differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pimecrolimus 💬 Pimecrolimus [1] 160 💬 💬
56 Osteoclast differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬
57 Osteoclast differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬
58 Osteoclast differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Voclosporin 💬 Voclosporin [2] 49, 222 💬 💬
59 Osteoclast differentiation 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬 💬
60 Osteoclast differentiation 💬
 [1] SYK 💬 Fostamatinib 💬 Fostamatinib [4] 46, 49, 61, 66 💬 💬
61 Osteoclast differentiation 💬
 [2] TGFB1, TGFB2 💬 Fresolimumab 💬 Fresolimumab [3] 51, 85, 222 💬 💬
62 Osteoclast differentiation 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬
63 Osteoclast differentiation 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬
64 Osteoclast differentiation 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬
65 Osteoclast differentiation 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬
66 Osteoclast differentiation 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬
67 Osteoclast differentiation 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬
68 Osteoclast differentiation 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬 💬
69 Osteoclast differentiation 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬 💬
70 Osteoclast differentiation 💬
 [1] TNF 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬 💬
71 Osteoclast differentiation 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬
72 Osteoclast differentiation 💬
 [1] TNFSF11 💬 Denosumab 💬 Denosumab [8] 46, 50, 70, 93, 95, 96, 274, 299 💬 💬
73 Osteoclast differentiation 💬
 [1] TYK2 💬 Deucravacitinib 💬 Deucravacitinib [3] 49, 96, 97 💬 💬