Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Legionellosis 💬

[1] C3 💬

Pegcetacoplan 💬

[4] 2 , 61, 62, 222 💬

2

Legionellosis 💬

[1] CASP9 💬

[6] 19, 60, 65, 284, 285, 326 💬

3

Legionellosis 💬

[2] IL12A, IL12B 💬

Ustekinumab 💬

[16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬

Disease ID	Name
37	Generalised pustular psoriasis;Pustular psoriasis;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
56	Behcet disease;Behçet disease;BD;
65	Primary immunodeficiency;
84	Sarcoidosis;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
160	Congenital ichthyosis;
162	Pemphigoid;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

4

Legionellosis 💬

[1] IL1B 💬

Canakinumab 💬

[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
56	Behcet disease;Behçet disease;BD;
84	Sarcoidosis;
106	Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome;
107	Juvenile idiopathic arthritis;JIA;
108	TNF receptor-associated periodic syndrome;
113	Muscular dystrophy;
266	Familial mediterranean fever;
267	Hyper-IgD syndrome;HIDS;Mevalonate kinase deffiency;Hyperimmunoglobulinemia D and periodic fever syndrome;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;

5

Legionellosis 💬

[1] IL1B 💬

Gevokizumab 💬

[4] 41, 50, 56, 269 💬

6

Legionellosis 💬

[1] IL1B 💬

Rilonacept 💬

[4] 51, 106, 107, 266 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
106	Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome;
107	Juvenile idiopathic arthritis;JIA;
266	Familial mediterranean fever;

7

Legionellosis 💬

[3] IL1B, IL6, TNF 💬

Pirfenidone 💬

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

8

Legionellosis 💬

[1] IL6 💬

Olokizumab 💬

[2] 46, 96 💬

9

Legionellosis 💬

[1] IL6 💬

Siltuximab 💬

[2] 28, 331 💬

10

Legionellosis 💬

[1] IL6 💬

[2] 41, 46 💬

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