Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	CYP11A1	[5] Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis, Cortisol synthesis an ...	D10950	Levoketoconazole	[1] 75
2	CYP11B1	[4] Steroid hormone biosynthesis, Metabolic pathways, Cortisol synthesis and secretion, Cushing synd ...	D00410	Metyrapone	[1] 75
3	CYP11B1	[4] Steroid hormone biosynthesis, Metabolic pathways, Cortisol synthesis and secretion, Cushing synd ...	D10950	Levoketoconazole	[1] 75
4	CYP17A1	[6] Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis, Prolactin signaling p ...	D00351	Ketoconazole	[3] 8, 13, 75
5	CYP17A1	[6] Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis, Prolactin signaling p ...	D10950	Levoketoconazole	[1] 75
6	AGTR1	[9] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth musc ...	D00150	Angiotensin II	[7] 17, 19, 46, 66, 86, 222, 224
7	AGTR1	[9] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth musc ...	D00400	Valsartan	[7] 57, 58, 66, 75, 218, 222, 224
8	AGTR1	[9] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth musc ...	D00522	Candesartan	[2] 58, 67
9	AGTR1	[9] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth musc ...	D00523	Irbesartan	[4] 66, 167, 168, 222
10	AGTR1	[9] Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth musc ...	D00626	Candesartan cilexetil	[1] 67

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