Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 CDK4 [5] PI3K-Akt signaling pathway, Tight junction, T cell receptor signaling pathway, Viral carcinogenesis, Small cell lung cancer D10688 Abemaciclib [1] 34
2 CDK6 [3] PI3K-Akt signaling pathway, Viral carcinogenesis, Small cell lung cancer D10688 Abemaciclib [1] 34
3 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00113 Atropine [2] 2, 299
4 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00138 Scopolamine [1] 2
5 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00270 Chlorpromazine [1] 254
6 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00397 Tropicamide [3] 6, 13, 19
7 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00465 Oxybutynin [3] 6, 13, 53
8 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00481 Propantheline [1] 26
9 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00722 Oxybutynin [3] 6, 13, 53
10 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00765 Rocuronium [1] 296
11 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00787 Trihexyphenidyl [2] 5, 6
12 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00789 Chlorpromazine [1] 254
13 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D01000 Bethanechol [1] 98
14 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D01077 Atropine [2] 2, 299
15 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D02069 Atropine [2] 2, 299
16 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D02212 Ipratropium [2] 6, 86
17 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D03011 Atropine [2] 2, 299
18 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D03274 Chlorpromazine [1] 254
19 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D03814 Atropine [2] 2, 299
20 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D04034 Chlorpromazine [1] 254
21 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D08441 Propiverine [1] 226
22 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D08638 Trihexyphenidyl [2] 5, 6
23 CHRM1 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D11383 Blarcamesine [1] 156
24 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00113 Atropine [2] 2, 299
25 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00138 Scopolamine [1] 2
26 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00270 Chlorpromazine [1] 254
27 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00397 Tropicamide [3] 6, 13, 19
28 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00465 Oxybutynin [3] 6, 13, 53
29 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00481 Propantheline [1] 26
30 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00525 Pilocarpine [3] 6, 53, 299
31 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00722 Oxybutynin [3] 6, 13, 53
32 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00765 Rocuronium [1] 296
33 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00787 Trihexyphenidyl [2] 5, 6
34 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D00789 Chlorpromazine [1] 254
35 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D01000 Bethanechol [1] 98
36 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D01077 Atropine [2] 2, 299
37 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D02069 Atropine [2] 2, 299
38 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D02200 Pilocarpine [3] 6, 53, 299
39 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D02212 Ipratropium [2] 6, 86
40 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D03011 Atropine [2] 2, 299
41 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D03274 Chlorpromazine [1] 254
42 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D03814 Atropine [2] 2, 299
43 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D04034 Chlorpromazine [1] 254
44 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D05478 Pilocarpine [3] 6, 53, 299
45 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D07226 Fesoterodine [1] 6
46 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D08441 Propiverine [1] 226
47 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D08638 Trihexyphenidyl [2] 5, 6
48 CHRM2 [2] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D11383 Blarcamesine [1] 156
49 CSF1 [6] Ras signaling pathway, Rap1 signaling pathway, Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, TNF signaling pathway, Rheumatoid arthritis D06402 Sunitinib [2] 28, 34
50 CSF1 [6] Ras signaling pathway, Rap1 signaling pathway, Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, TNF signaling pathway, Rheumatoid arthritis D08552 Sunitinib [2] 28, 34
51 CSF1R [5] Ras signaling pathway, Rap1 signaling pathway, Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer D11270 Pexidartinib [1] 34
52 CSF3R [1] PI3K-Akt signaling pathway D03235 Filgrastim [34] 2, 6, 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331
53 CSF3R [1] PI3K-Akt signaling pathway D03247 Lenograstim [7] 2, 13, 16, 18, 19, 57, 65
54 CSF3R [1] PI3K-Akt signaling pathway D06889 Pegfilgrastim [1] 60
55 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D01977 Gefitinib [1] 75
56 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D03455 Cetuximab [5] 34, 51, 86, 89, 331
57 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D04023 Erlotinib [1] 94
58 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D04024 Lapatinib [3] 34, 74, 75
59 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D07907 Erlotinib [1] 94
60 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D08108 Lapatinib [3] 34, 74, 75
61 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D11251 Icotinib [1] 34
62 EGFR [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D11772 Tesevatinib [1] 67
63 EPHA2 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D03658 Dasatinib [2] 51, 85
64 EPHA2 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D06414 Dasatinib [2] 51, 85
65 EPOR [1] PI3K-Akt signaling pathway D03231 Erythropoietin [10] 2, 6, 13, 18, 22, 46, 47, 70, 95, 96
66 EPOR [1] PI3K-Akt signaling pathway D09946 Peginesatide [1] 283
67 ERBB2 [5] Platinum drug resistance, PI3K-Akt signaling pathway, Tight junction, Proteoglycans in cancer, Prostate cancer D04024 Lapatinib [3] 34, 74, 75
68 ERBB2 [5] Platinum drug resistance, PI3K-Akt signaling pathway, Tight junction, Proteoglycans in cancer, Prostate cancer D08108 Lapatinib [3] 34, 74, 75
69 ERBB2 [5] Platinum drug resistance, PI3K-Akt signaling pathway, Tight junction, Proteoglycans in cancer, Prostate cancer D11772 Tesevatinib [1] 67
70 FGFR1 [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Proteoglycans in cancer, Prostate cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
71 FGFR1 [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Proteoglycans in cancer, Prostate cancer D11589 Infigratinib [1] 276
72 FGFR3 [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
73 FGFR3 [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D11589 Infigratinib [1] 276
74 FGFR2 [6] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Prostate cancer D05338 Palifermin [5] 13, 36, 38, 39, 65
75 FGFR2 [6] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Prostate cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
76 FGFR2 [6] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Prostate cancer D11589 Infigratinib [1] 276
77 FLT1 [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D03218 Axitinib [1] 34
78 FLT1 [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D06402 Sunitinib [2] 28, 34
79 FLT1 [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D08552 Sunitinib [2] 28, 34
80 FLT1 [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D08881 Cediranib [1] 34
81 FLT1 [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D10481 Nintedanib [5] 51, 85, 89, 227, 228
82 FLT3 [3] Ras signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer D06272 Sorafenib [2] 34, 86
83 FLT3 [3] Ras signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer D06402 Sunitinib [2] 28, 34
84 FLT3 [3] Ras signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer D08524 Sorafenib [2] 34, 86
85 FLT3 [3] Ras signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer D08552 Sunitinib [2] 28, 34
86 FLT3 [3] Ras signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer D11270 Pexidartinib [1] 34
87 FLT4 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D03218 Axitinib [1] 34
88 FLT4 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D06272 Sorafenib [2] 34, 86
89 FLT4 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D06402 Sunitinib [2] 28, 34
90 FLT4 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D08524 Sorafenib [2] 34, 86
91 FLT4 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D08552 Sunitinib [2] 28, 34
92 FLT4 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D08881 Cediranib [1] 34
93 FLT4 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D10481 Nintedanib [5] 51, 85, 89, 227, 228
94 FLT4 [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D11772 Tesevatinib [1] 67
95 MTOR [9] PI3K-Akt signaling pathway, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Proteoglycans in cancer, Prostate cancer D00753 Sirolimus [41] 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331
96 MTOR [9] PI3K-Akt signaling pathway, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Proteoglycans in cancer, Prostate cancer D02714 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277
97 MTOR [9] PI3K-Akt signaling pathway, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Proteoglycans in cancer, Prostate cancer D06068 Temsirolimus [4] 13, 34, 89, 331
98 GHR [1] PI3K-Akt signaling pathway D02691 Somatotropin [23] 2, 3, 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299
99 GHR [1] PI3K-Akt signaling pathway D03297 Mecasermin [6] 65, 78, 96, 168, 265, 299
100 GHR [1] PI3K-Akt signaling pathway D04870 Mecasermin [6] 65, 78, 96, 168, 265, 299
101 GHR [1] PI3K-Akt signaling pathway D05394 Pegvisomant [1] 78
102 GHR [1] PI3K-Akt signaling pathway D11193 Somavaratan [1] 78
103 GHR [1] PI3K-Akt signaling pathway D11194 Somapacitan [1] 78
104 GHR [1] PI3K-Akt signaling pathway D11486 Lonapegsomatropin [1] 78
105 IFNA1 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
106 IFNA1 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
107 IFNA2 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
108 IFNA2 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
109 IFNA4 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
110 IFNA4 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
111 IFNA5 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
112 IFNA5 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
113 IFNA6 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
114 IFNA6 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
115 IFNA7 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
116 IFNA7 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
117 IFNA8 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
118 IFNA8 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
119 IFNA10 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
120 IFNA10 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
121 IFNA13 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
122 IFNA13 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
123 IFNA14 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
124 IFNA14 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
125 IFNA16 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
126 IFNA16 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
127 IFNA17 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
128 IFNA17 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
129 IFNA21 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
130 IFNA21 [4] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
131 IFNAR1 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D00745 Interferon alfa-2a [1] 56
132 IFNAR1 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D00746 Interferon beta-1b [1] 13
133 IFNAR1 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D02745 Interferon alfa-2b [2] 25, 34
134 IFNAR1 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D03305 Interferon alfa [6] 13, 25, 26, 28, 56, 96
135 IFNAR1 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D04554 Interferon beta-1a [4] 13, 26, 96, 97
136 IFNAR1 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D10483 Peginterferon beta-1a [1] 13
137 IFNAR1 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D11082 Anifrolumab [2] 46, 49
138 IFNAR2 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D00745 Interferon alfa-2a [1] 56
139 IFNAR2 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D00746 Interferon beta-1b [1] 13
140 IFNAR2 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D02745 Interferon alfa-2b [2] 25, 34
141 IFNAR2 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D03305 Interferon alfa [6] 13, 25, 26, 28, 56, 96
142 IFNAR2 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D04554 Interferon beta-1a [4] 13, 26, 96, 97
143 IFNAR2 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D10483 Peginterferon beta-1a [1] 13
144 IFNAR2 [2] PI3K-Akt signaling pathway, Toll-like receptor signaling pathway D11082 Anifrolumab [2] 46, 49
145 IGF1R [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Progesterone-mediated oocyte maturation, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D03297 Mecasermin [6] 65, 78, 96, 168, 265, 299
146 IGF1R [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Progesterone-mediated oocyte maturation, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D04870 Mecasermin [6] 65, 78, 96, 168, 265, 299
147 IGF1R [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Progesterone-mediated oocyte maturation, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D09680 Teprotumumab [1] 51
148 IGF1R [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Progesterone-mediated oocyte maturation, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D09925 Linsitinib [1] 232
149 IL2RA [4] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation D00748 Aldesleukin [6] 2, 35, 49, 65, 96, 97
150 IL2RA [4] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation D03058 Basiliximab [6] 2, 50, 66, 97, 222, 228
151 IL2RA [4] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation D03639 Daclizumab [8] 13, 56, 60, 65, 97, 107, 283, 284
152 IL2RB [5] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Transcriptional misregulation in cancer D00748 Aldesleukin [6] 2, 35, 49, 65, 96, 97
153 IL2RG [5] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Primary immunodeficiency D00748 Aldesleukin [6] 2, 35, 49, 65, 96, 97
154 IL4 [4] PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway D03117 Binetrakin [1] 46
155 IL4R [3] PI3K-Akt signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation D10354 Dupilumab [4] 51, 98, 160, 162
156 IL6 [11] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Prion disease, Salmonella infection, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
157 IL6 [11] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Prion disease, Salmonella infection, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D08976 Pomalidomide [6] 28, 34, 51, 85, 227, 331
158 IL6 [11] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Prion disease, Salmonella infection, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D09669 Siltuximab [2] 28, 331
159 IL6 [11] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Prion disease, Salmonella infection, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D10080 Sirukumab [2] 41, 46
160 IL6R [3] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th17 cell differentiation D02596 Tocilizumab [21] 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331
161 IL6R [3] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th17 cell differentiation D10161 Sarilumab [5] 41, 46, 84, 107, 271
162 IL6R [3] Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Th17 cell differentiation D11079 Satralizumab [2] 11, 13
163 INSR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D00085 Insulin human [2] 96, 156
164 INSR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D03230 Insulin human [2] 96, 156
165 INSR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D03250 Insulin glargine [1] 299
166 INSR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D04539 Insulin detemir [1] 299
167 ITGA4 [3] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection D06590 Firategrast [1] 13
168 ITGA4 [3] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection D06886 Natalizumab [6] 13, 15, 25, 46, 63, 96
169 ITGA4 [3] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection D08083 Vedolizumab [3] 94, 96, 97
170 ITGA4 [3] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection D10540 Abrilumab [2] 96, 97
171 ITGB7 [3] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Transcriptional misregulation in cancer D08083 Vedolizumab [3] 94, 96, 97
172 ITGB7 [3] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Transcriptional misregulation in cancer D09901 Etrolizumab [2] 96, 97
173 ITGB7 [3] PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Transcriptional misregulation in cancer D10540 Abrilumab [2] 96, 97
174 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D09959 Ruxolitinib [1] 228
175 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D09970 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
176 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10308 Baricitinib [13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325
177 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10653 Peficitinib [1] 46
178 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10871 Filgotinib [6] 46, 53, 96, 97, 222, 271
179 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10944 Itacitinib [5] 46, 51, 60, 97, 228
180 JAK1 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis D10994 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271
181 JAK2 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Prolactin signaling pathway, Toxoplasmosis, Tuberculosis D09959 Ruxolitinib [1] 228
182 JAK2 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Prolactin signaling pathway, Toxoplasmosis, Tuberculosis D09970 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
183 JAK2 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Prolactin signaling pathway, Toxoplasmosis, Tuberculosis D10308 Baricitinib [13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325
184 JAK2 [7] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Prolactin signaling pathway, Toxoplasmosis, Tuberculosis D10653 Peficitinib [1] 46
185 JAK3 [6] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral carcinogenesis, Primary immunodeficiency D09970 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
186 JAK3 [6] PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral carcinogenesis, Primary immunodeficiency D10653 Peficitinib [1] 46
187 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D03218 Axitinib [1] 34
188 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D06272 Sorafenib [2] 34, 86
189 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D06402 Sunitinib [2] 28, 34
190 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D08524 Sorafenib [2] 34, 86
191 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D08552 Sunitinib [2] 28, 34
192 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D08881 Cediranib [1] 34
193 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D10062 Cabozantinib [1] 34
194 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
195 KDR [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Proteoglycans in cancer D11772 Tesevatinib [1] 67
196 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D01441 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
197 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D03658 Dasatinib [2] 51, 85
198 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D06272 Sorafenib [2] 34, 86
199 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D06402 Sunitinib [2] 28, 34
200 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D06414 Dasatinib [2] 51, 85
201 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D08066 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
202 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D08524 Sorafenib [2] 34, 86
203 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D08552 Sunitinib [2] 28, 34
204 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D08953 Nilotinib [5] 6, 8, 34, 51, 86
205 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D10229 Masitinib [6] 2, 5, 6, 13, 46, 96
206 KIT [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D11270 Pexidartinib [1] 34
207 MET [6] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer, Proteoglycans in cancer, Renal cell carcinoma D10062 Cabozantinib [1] 34
208 NFKB1 [20] Ras signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Prolactin signaling pathway, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis, Prostate cancer, Small cell lung cancer D01146 Iguratimod [4] 46, 51, 53, 271
209 NGF [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D09387 Tanezumab [2] 226, 298
210 NGFR [4] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Transcriptional misregulation in cancer D11028 Cenegermin [2] 53, 90
211 PDGFRA [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D01441 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
212 PDGFRA [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D06402 Sunitinib [2] 28, 34
213 PDGFRA [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08066 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
214 PDGFRA [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08552 Sunitinib [2] 28, 34
215 PDGFRA [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08953 Nilotinib [5] 6, 8, 34, 51, 86
216 PDGFRA [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
217 PDGFRB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D03658 Dasatinib [2] 51, 85
218 PDGFRB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D06272 Sorafenib [2] 34, 86
219 PDGFRB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D06402 Sunitinib [2] 28, 34
220 PDGFRB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D06414 Dasatinib [2] 51, 85
221 PDGFRB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08524 Sorafenib [2] 34, 86
222 PDGFRB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08552 Sunitinib [2] 28, 34
223 PDGFRB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08953 Nilotinib [5] 6, 8, 34, 51, 86
224 PDGFRB [5] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D10481 Nintedanib [5] 51, 85, 89, 227, 228
225 PGF [3] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway D09574 Aflibercept [2] 90, 166
226 PIK3CA [28] Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11158 Leniolisib [2] 53, 65
227 PIK3CB [28] Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11158 Leniolisib [2] 53, 65
228 PIK3CD [28] Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11158 Leniolisib [2] 53, 65
229 PIK3CD [28] Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11437 Parsaclisib [3] 35, 53, 61
230 PRKAA1 [3] PI3K-Akt signaling pathway, Tight junction, Thermogenesis D00944 Metformin [24] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
231 PRKAA1 [3] PI3K-Akt signaling pathway, Tight junction, Thermogenesis D04966 Metformin [24] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
232 PRKAA2 [3] PI3K-Akt signaling pathway, Tight junction, Thermogenesis D00944 Metformin [24] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
233 PRKAA2 [3] PI3K-Akt signaling pathway, Tight junction, Thermogenesis D04966 Metformin [24] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
234 MAP2K1 [22] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D09666 Selumetinib [1] 34
235 MAP2K1 [22] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10175 Trametinib [4] 2, 34, 279, 280
236 MAP2K1 [22] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10405 Cobimetinib [1] 280
237 MAP2K1 [22] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10604 Binimetinib [1] 34
238 MAP2K2 [19] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D09666 Selumetinib [1] 34
239 MAP2K2 [19] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10175 Trametinib [4] 2, 34, 279, 280
240 MAP2K2 [19] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10405 Cobimetinib [1] 280
241 MAP2K2 [19] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10604 Binimetinib [1] 34
242 PRL [2] PI3K-Akt signaling pathway, Prolactin signaling pathway D00780 Bromocriptine [2] 6, 74
243 PRL [2] PI3K-Akt signaling pathway, Prolactin signaling pathway D00987 Cabergoline [3] 6, 74, 75
244 PRL [2] PI3K-Akt signaling pathway, Prolactin signaling pathway D01348 Terguride [2] 51, 86
245 PRL [2] PI3K-Akt signaling pathway, Prolactin signaling pathway D03165 Bromocriptine [2] 6, 74
246 RAF1 [19] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Tuberculosis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer D06272 Sorafenib [2] 34, 86
247 RAF1 [19] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Tuberculosis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer D08524 Sorafenib [2] 34, 86
248 BCL2 [10] Platinum drug resistance, Sphingolipid signaling pathway, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Shigellosis, Salmonella infection, Toxoplasmosis, Tuberculosis, Prostate cancer, Small cell lung cancer D10679 Venetoclax [1] 28
249 RELA [20] Ras signaling pathway, Sphingolipid signaling pathway, PI3K-Akt signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Prolactin signaling pathway, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis, Prostate cancer, Small cell lung cancer D12181 Edasalonexent [1] 113
250 RXRA [7] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02754 Acitretin [1] 37
251 RXRA [7] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02815 Alitretinoin [1] 49
252 RXRA [7] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D03106 Bexarotene [2] 13, 75
253 SYK [4] PI3K-Akt signaling pathway, Platelet activation, Tuberculosis, Viral carcinogenesis D09347 Fostamatinib [4] 46, 49, 61, 66
254 VEGFA [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Proteoglycans in cancer, Renal cell carcinoma, Rheumatoid arthritis D05697 Ranibizumab [4] 34, 166, 227, 301
255 VEGFA [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Proteoglycans in cancer, Renal cell carcinoma, Rheumatoid arthritis D06409 Bevacizumab [9] 13, 34, 85, 86, 87, 89, 227, 280, 331
256 VEGFA [8] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Proteoglycans in cancer, Renal cell carcinoma, Rheumatoid arthritis D09574 Aflibercept [2] 90, 166
257 VEGFB [4] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Relaxin signaling pathway D09574 Aflibercept [2] 90, 166
258 VWF [2] PI3K-Akt signaling pathway, Platelet activation D11160 Caplacizumab [1] 64
259 FGF23 [4] Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton D10913 Burosumab [1] 238
260 CASP9 [10] Platinum drug resistance, PI3K-Akt signaling pathway, VEGF signaling pathway, Thyroid hormone signaling pathway, Prion disease, Toxoplasmosis, Tuberculosis, Prostate cancer, Small cell lung cancer, Viral myocarditis D11195 Rimiducid [6] 19, 60, 65, 284, 285, 326
261 CD19 [2] PI3K-Akt signaling pathway, Primary immunodeficiency D11757 Inebilizumab [4] 11, 13, 51, 300