Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 SIGMAR1 💬 2件: Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
2 SIGMAR1 💬 2件: Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases Blarcamesine 💬 Blarcamesine 1件: 156 💬
3 CHRM1 💬 8件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Cholinergic synapse, Regulation of actin cytoskeleton, Alzheimer disease, Pathways of neurodegeneration - multiple diseases Blarcamesine 💬 Blarcamesine 1件: 156 💬
4 CHRM2 💬 6件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Cholinergic synapse, Regulation of actin cytoskeleton Blarcamesine 💬 Blarcamesine 1件: 156 💬
5 CHRM3 💬 11件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Cholinergic synapse, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Alzheimer disease, Pathways of neurodegeneration - multiple diseases Blarcamesine 💬 Blarcamesine 1件: 156 💬
6 CHRM4 💬 3件: Neuroactive ligand-receptor interaction, Cholinergic synapse, Regulation of actin cytoskeleton Blarcamesine 💬 Blarcamesine 1件: 156 💬
7 CHRM5 💬 6件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Cholinergic synapse, Regulation of actin cytoskeleton, Alzheimer disease, Pathways of neurodegeneration - multiple diseases Blarcamesine 💬 Blarcamesine 1件: 156 💬
8 CNR1 💬 4件: Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endocannabinoid signaling Cannabidiol 💬 Cannabidiol 20件: 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
9 CNR2 💬 1件: Neuroactive ligand-receptor interaction Cannabidiol 💬 Cannabidiol 20件: 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
10 DRD2 💬 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Risperidone 💬 Risperidone 5件: 8, 156, 179, 187, 206 💬
11 S1PR1 💬 3件: FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction Fingolimod 💬 Fingolimod 3件: 13, 14, 156 💬
12 GABRA1 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
13 GABRA2 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
14 GABRA3 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
15 GABRA4 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
16 GABRA5 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
17 GABRA6 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
18 GABRB1 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
19 GABRB2 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
20 GABRB3 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
21 GABRD 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
22 GABRE 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
23 GABRG1 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
24 GABRG2 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
25 GABRG3 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
26 GABRP 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
27 GRIA1 💬 14件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
28 GRIA2 💬 15件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
29 GRIA3 💬 13件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction, Transcriptional misregulation in cancer Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
30 GRIA4 💬 10件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Huntington disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
31 GRIK1 💬 2件: Neuroactive ligand-receptor interaction, Glutamatergic synapse Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
32 GRIK2 💬 2件: Neuroactive ligand-receptor interaction, Glutamatergic synapse Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
33 GRIK3 💬 2件: Neuroactive ligand-receptor interaction, Glutamatergic synapse Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
34 GRIK4 💬 2件: Neuroactive ligand-receptor interaction, Glutamatergic synapse Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
35 GRIK5 💬 2件: Neuroactive ligand-receptor interaction, Glutamatergic synapse Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
36 GRIN1 💬 18件: Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
37 GRIN1 💬 18件: Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Ketamine 💬 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215 💬
38 GRIN2A 💬 19件: Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
39 GRIN2A 💬 19件: Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus Ketamine 💬 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215 💬
40 GRIN2B 💬 19件: Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
41 GRIN2B 💬 19件: Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus Ketamine 💬 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215 💬
42 GRIN2C 💬 15件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
43 GRIN2C 💬 15件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Ketamine 💬 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215 💬
44 GRIN2D 💬 15件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
45 GRIN2D 💬 15件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Ketamine 💬 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215 💬
46 HMGCR 💬 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion Lovastatin 💬 Lovastatin 11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
47 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Risperidone 💬 Risperidone 5件: 8, 156, 179, 187, 206 💬
48 INSR 💬 22件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, cGMP-PKG signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Adherens junction, Insulin signaling pathway, Ovarian steroidogenesis, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Diabetic cardiomyopathy Insulin human 💬 Insulin human 2件: 96, 156 💬
49 ACHE 💬 2件: Glycerophospholipid metabolism, Cholinergic synapse Donepezil 💬 Donepezil 9件: 5, 6, 13, 46, 78, 124, 127, 156, 206 💬
50 GABRQ 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
51 SCN1A 💬 1件: Dopaminergic synapse Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
52 SCN2A 💬 1件: Taste transduction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
53 SCN3A 💬 1件: Taste transduction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
54 SCN5A 💬 1件: Adrenergic signaling in cardiomyocytes Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
55 SCN9A 💬 1件: Taste transduction Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
56 SLC6A2 💬 1件: Synaptic vesicle cycle Desipramine 💬 Desipramine 2件: 120, 156 💬
57 SLC6A4 💬 2件: Synaptic vesicle cycle, Serotonergic synapse Desipramine 💬 Desipramine 2件: 120, 156 💬
58 CA2 💬 7件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
59 CA4 💬 3件: Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
60 CACNA1C 💬 34件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
61 CACNA1D 💬 35件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Tight junction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Carbohydrate digestion and absorption, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
62 CACNA1F 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬
63 CACNA1S 💬 27件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Topiramate 💬 Topiramate 6件: 6, 97, 140, 144, 156, 193 💬