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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
指定難病告示番号
1
IFNG
💬
1. IFNG
×
Name
Full Name
IFNG
interferon gamma
32件:
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
32件:
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Fontolizumab
Fontolizumab
💬
1. IFNG
×
Name
Other Names
Fontolizumab
Fontolizumab (USAN/INN)
フォントリズマブ
Fontolizumab
1件:
46
46
💬
1. IFNG
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
2
IFNG
💬
2. IFNG
×
Name
Full Name
IFNG
interferon gamma
32件:
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
32件:
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Emapalumab
Emapalumab
💬
2. IFNG
×
Name
Other Names
Emapalumab
Emapalumab (USAN/INN)
Emapalumab (genetical recombination) (JAN)
Emapalumab-lzsg
Gamifant (TN)
エマパルマブ
Emapalumab
3件:
49
49
,
65
,
107
💬
2. IFNG
×
告示番号
日本語名
英語名
49
全身性エリテマトーデス
Systemic lupus erythematosus
65
原発性免疫不全症候群
Primary immunodeficiency
107
若年性特発性関節炎
Juvenile idiopathic arthritis
3
SMAD7
💬
3. SMAD7
×
Name
Full Name
SMAD7
SMAD family member 7
2件:
TGF-beta signaling pathway
TGF-beta signaling pathway
,
Hippo signaling pathway
Mongersen
Mongersen
💬
3. SMAD7
×
Name
Other Names
Mongersen
Mongersen (INN)
モンジャーセン
Mongersen
2件:
96
96
,
97
💬
3. SMAD7
×
告示番号
日本語名
英語名
96
クローン病;回腸末端炎
Crohn disease
97
潰瘍性大腸炎
Ulcerative colitis
4
RGMA
💬
4. RGMA
×
Name
Full Name
RGMA
repulsive guidance molecule BMP co-receptor a
2件:
TGF-beta signaling pathway
TGF-beta signaling pathway
,
Axon guidance
Elezanumab
Elezanumab
💬
4. RGMA
×
Name
Other Names
Elezanumab
Elezanumab (USAN/INN)
エレザヌマブ
Elezanumab
1件:
13
13
💬
4. RGMA
×
告示番号
日本語名
英語名
13
多発性硬化症/視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
5
ROCK1
💬
5. ROCK1
×
Name
Full Name
ROCK1
Rho associated coiled-coil containing protein kinase 1
20件:
cGMP-PKG signaling pathway
cGMP-PKG signaling pathway
,
cAMP signaling pathway
,
Chemokine signaling pathway
,
Sphingolipid signaling pathway
,
Vascular smooth muscle contraction
,
TGF-beta signaling pathway
,
Axon guidance
,
Focal adhesion
,
Tight junction
,
Platelet activation
,
Leukocyte transendothelial migration
,
Regulation of actin cytoskeleton
,
Oxytocin signaling pathway
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Yersinia infection
,
Human cytomegalovirus infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
20件:
cGMP-PKG signaling pathway
,
cAMP signaling pathway
,
Chemokine signaling pathway
,
Sphingolipid s
...
Fasudil
Fasudil
💬
5. ROCK1
×
Name
Other Names
Fasudil
Fasudil (INN)
ファスジル
Fasudil
4件:
2
2
,
5
,
7
,
51
💬
5. ROCK1
×
告示番号
日本語名
英語名
2
筋萎縮性側索硬化症
Amyotrophic lateral sclerosis
5
進行性核上性麻痺
Progressive supranuclear palsy
7
大脳皮質基底核変性症
Corticobasal degeneration
51
全身性強皮症
Scleroderma
6
TGFB1
💬
6. TGFB1
×
Name
Full Name
TGFB1
transforming growth factor beta 1
34件:
MAPK signaling pathway
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
FoxO signaling pathway
,
Cell cycle
,
Cellular senescence
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Hippo signaling pathway
,
Th17 cell differentiation
,
Intestinal immune network for IgA production
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Leishmaniasis
,
Chagas disease
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis B
,
Human T-cell leukemia virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
Colorectal cancer
,
Renal cell carcinoma
,
Pancreatic cancer
,
Chronic myeloid leukemia
,
Hepatocellular carcinoma
,
Gastric cancer
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Hypertrophic cardiomyopathy
,
Dilated cardiomyopathy
,
Diabetic cardiomyopathy
34件:
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
FoxO signaling pathway
,
Cell cy
...
Fresolimumab
Fresolimumab
💬
6. TGFB1
×
Name
Other Names
Fresolimumab
Fresolimumab (USAN/INN)
フレソリムマブ
Fresolimumab
3件:
51
51
,
85
,
222
💬
6. TGFB1
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
7
TGFB2
💬
7. TGFB2
×
Name
Full Name
TGFB2
transforming growth factor beta 2
31件:
MAPK signaling pathway
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
FoxO signaling pathway
,
Cell cycle
,
Cellular senescence
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Hippo signaling pathway
,
AGE-RAGE signaling pathway in diabetic complications
,
Leishmaniasis
,
Chagas disease
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis B
,
Human T-cell leukemia virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Colorectal cancer
,
Renal cell carcinoma
,
Pancreatic cancer
,
Chronic myeloid leukemia
,
Hepatocellular carcinoma
,
Gastric cancer
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Hypertrophic cardiomyopathy
,
Dilated cardiomyopathy
,
Diabetic cardiomyopathy
31件:
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
FoxO signaling pathway
,
Cell cy
...
Fresolimumab
Fresolimumab
💬
7. TGFB2
×
Name
Other Names
Fresolimumab
Fresolimumab (USAN/INN)
フレソリムマブ
Fresolimumab
3件:
51
51
,
85
,
222
💬
7. TGFB2
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
8
TGFB3
💬
8. TGFB3
×
Name
Full Name
TGFB3
transforming growth factor beta 3
28件:
MAPK signaling pathway
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
FoxO signaling pathway
,
Cell cycle
,
Cellular senescence
,
TGF-beta signaling pathway
,
Hippo signaling pathway
,
AGE-RAGE signaling pathway in diabetic complications
,
Leishmaniasis
,
Chagas disease
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis B
,
Human T-cell leukemia virus 1 infection
,
Pathways in cancer
,
Colorectal cancer
,
Renal cell carcinoma
,
Pancreatic cancer
,
Chronic myeloid leukemia
,
Hepatocellular carcinoma
,
Gastric cancer
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Hypertrophic cardiomyopathy
,
Dilated cardiomyopathy
,
Diabetic cardiomyopathy
28件:
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
FoxO signaling pathway
,
Cell cy
...
Fresolimumab
Fresolimumab
💬
8. TGFB3
×
Name
Other Names
Fresolimumab
Fresolimumab (USAN/INN)
フレソリムマブ
Fresolimumab
3件:
51
51
,
85
,
222
💬
8. TGFB3
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
9
TNF
💬
9. TNF
×
Name
Full Name
TNF
tumor necrosis factor
67件:
Antifolate resistance
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
NF-kappa B signaling pathway
,
Sphingolipid signaling pathway
,
mTOR signaling pathway
,
Apoptosis
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
Hematopoietic cell lineage
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Alcoholic liver disease
,
Type I diabetes mellitus
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Legionellosis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Asthma
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Hypertrophic cardiomyopathy
,
Dilated cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
67件:
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Viral pr
...
Etanercept
Etanercept
💬
9. TNF
×
Name
Other Names
Etanercept
Etanercept (USAN/INN)
Etanercept (genetical recombination) (JAN)
Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN)
Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN)
Enbrel (TN)
エタネルセプト
エンブレル
エタネルセプトBS
Etanercept
16件:
15
15
,
28
,
35
,
38
,
39
,
46
,
50
,
53
,
56
,
60
,
85
,
107
,
228
,
270
,
271
,
285
💬
9. TNF
×
告示番号
日本語名
英語名
15
封入体筋炎
Inclusion body myositis
28
全身性アミロイドーシス
Systemic amyloidosis
35
天疱瘡
Pemphigus
38
スティーヴンス・ジョンソン症候群;皮膚粘膜眼症候群
Stevens-Johnson syndrome
39
中毒性表皮壊死症
Toxic epidermal necrolysis
46
悪性関節リウマチ
Malignant rheumatoid arthritis
50
皮膚筋炎/多発性筋炎
Dermatomyositis
53
シェーグレン症候群
Sjogren syndrome
56
ベーチェット病
Behcet disease
60
再生不良性貧血
Aplastic anemia
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
107
若年性特発性関節炎
Juvenile idiopathic arthritis
228
閉塞性細気管支炎
Bronchiolitis obliterans
270
慢性再発性多発性骨髄炎
Chronic recurrent multifocal osteomyelitis
271
強直性脊椎炎
Ankylosing spondylitis
285
ファンコニ貧血
Fanconi anemia
10
TNF
💬
10. TNF
×
Name
Full Name
TNF
tumor necrosis factor
67件:
Antifolate resistance
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
NF-kappa B signaling pathway
,
Sphingolipid signaling pathway
,
mTOR signaling pathway
,
Apoptosis
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
Hematopoietic cell lineage
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Alcoholic liver disease
,
Type I diabetes mellitus
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Legionellosis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Asthma
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Hypertrophic cardiomyopathy
,
Dilated cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
67件:
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Viral pr
...
Thalidomide
Thalidomide
💬
10. TNF
×
Name
Other Names
Thalidomide
Thalidomide (JAN/USP/INN)
Thalomid (TN)
Thaled (TN)
サリドマイド
サレド
Thalidomide
20件:
2
2
,
16
,
20
,
28
,
49
,
51
,
53
,
56
,
65
,
84
,
85
,
94
,
96
,
97
,
227
,
271
,
280
,
298
,
300
,
331
💬
10. TNF
×
告示番号
日本語名
英語名
2
筋萎縮性側索硬化症
Amyotrophic lateral sclerosis
16
クロウ・深瀬症候群
Crow-Fukase syndrome
20
副腎白質ジストロフィー
Adrenoleukodystrophy
28
全身性アミロイドーシス
Systemic amyloidosis
49
全身性エリテマトーデス
Systemic lupus erythematosus
51
全身性強皮症
Scleroderma
53
シェーグレン症候群
Sjogren syndrome
56
ベーチェット病
Behcet disease
65
原発性免疫不全症候群
Primary immunodeficiency
84
サルコイドーシス
Sarcoidosis
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
94
原発性硬化性胆管炎
Primary sclerosing cholangitis
96
クローン病;回腸末端炎
Crohn disease
97
潰瘍性大腸炎
Ulcerative colitis
227
オスラー病;遺伝性出血性末梢血管拡張症
Osler disease
271
強直性脊椎炎
Ankylosing spondylitis
280
巨大動静脈奇形(頚部顔面又は四肢病変)
Huge arteriovenous malformation with cervicofacial or limb lesion
298
遺伝性膵炎
Hereditary pancreatitis
300
IgG4関連疾患
IgG4-related disease
331
特発性多中心性キャッスルマン病
Idiopathic multicentric castleman disease