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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
指定難病告示番号
1
CPT1C
💬
1. CPT1C
×
Name
Full Name
CPT1C
carnitine palmitoyltransferase 1C
8件:
Fatty acid degradation
Fatty acid degradation
,
Fatty acid metabolism
,
PPAR signaling pathway
,
AMPK signaling pathway
,
Thermogenesis
,
Adipocytokine signaling pathway
,
Glucagon signaling pathway
,
Alcoholic liver disease
8件:
Fatty acid degradation
,
Fatty acid metabolism
,
PPAR signaling pathway
,
AMPK signaling pathway
,
T
...
Perhexiline
Perhexiline
💬
1. CPT1C
×
Name
Other Names
Perhexiline
Perhexiline (INN)
ペルヘキシリン
Perhexiline
2件:
58
58
,
272
💬
1. CPT1C
×
告示番号
日本語名
英語名
58
肥大型心筋症
Hypertrophic cardiomyopathy
272
進行性骨化性線維異形成症
Fibrodysplasia ossificans progressiva
2
CPT1A
💬
2. CPT1A
×
Name
Full Name
CPT1A
carnitine palmitoyltransferase 1A
9件:
Fatty acid degradation
Fatty acid degradation
,
Fatty acid metabolism
,
PPAR signaling pathway
,
AMPK signaling pathway
,
Thermogenesis
,
Adipocytokine signaling pathway
,
Glucagon signaling pathway
,
Insulin resistance
,
Alcoholic liver disease
9件:
Fatty acid degradation
,
Fatty acid metabolism
,
PPAR signaling pathway
,
AMPK signaling pathway
,
T
...
Perhexiline
Perhexiline
💬
2. CPT1A
×
Name
Other Names
Perhexiline
Perhexiline (INN)
ペルヘキシリン
Perhexiline
2件:
58
58
,
272
💬
2. CPT1A
×
告示番号
日本語名
英語名
58
肥大型心筋症
Hypertrophic cardiomyopathy
272
進行性骨化性線維異形成症
Fibrodysplasia ossificans progressiva
3
CPT1B
💬
3. CPT1B
×
Name
Full Name
CPT1B
carnitine palmitoyltransferase 1B
10件:
Fatty acid degradation
Fatty acid degradation
,
Fatty acid metabolism
,
PPAR signaling pathway
,
AMPK signaling pathway
,
Thermogenesis
,
Adipocytokine signaling pathway
,
Glucagon signaling pathway
,
Insulin resistance
,
Alcoholic liver disease
,
Diabetic cardiomyopathy
10件:
Fatty acid degradation
,
Fatty acid metabolism
,
PPAR signaling pathway
,
AMPK signaling pathway
, ...
Perhexiline
Perhexiline
💬
3. CPT1B
×
Name
Other Names
Perhexiline
Perhexiline (INN)
ペルヘキシリン
Perhexiline
2件:
58
58
,
272
💬
3. CPT1B
×
告示番号
日本語名
英語名
58
肥大型心筋症
Hypertrophic cardiomyopathy
272
進行性骨化性線維異形成症
Fibrodysplasia ossificans progressiva
4
MTOR
💬
4. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
51件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
51件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Sirolimus
Sirolimus
💬
4. MTOR
×
Name
Other Names
Sirolimus
Sirolimus (JAN/USAN/INN)
Rapamune (TN)
Rapamycin (TN)
FYARRO
HYFTOR
シロリムス
ラパリムス
Sirolimus
40件:
2
2
,
13
,
15
,
17
,
19
,
34
,
35
,
36
,
46
,
49
,
51
,
53
,
60
,
61
,
62
,
63
,
65
,
66
,
67
,
84
,
85
,
86
,
89
,
96
,
98
,
137
,
157
,
158
,
192
,
193
,
222
,
256
,
277
,
278
,
279
,
280
,
281
,
283
,
300
,
331
💬
40件:
2
,
13
,
15
,
17
,
19
,
34
,
35
,
36
,
46
,
49
,
51
,
53
,
60
,
61
,
62
,
63
,
65
,
66
,
67
,
84
,
85
,
86
,
89
,
96
, ...
4. MTOR
×
告示番号
日本語名
英語名
2
筋萎縮性側索硬化症
Amyotrophic lateral sclerosis
13
多発性硬化症/視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
15
封入体筋炎
Inclusion body myositis
17
多系統萎縮症
Multiple system atrophy
19
ライソゾーム病
Lysosomal storage disease
34
神経線維腫症
Neurofibromatosis
35
天疱瘡
Pemphigus
36
表皮水疱症
Epidermolysis bullosa
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
51
全身性強皮症
Scleroderma
53
シェーグレン症候群
Sjogren syndrome
60
再生不良性貧血
Aplastic anemia
61
自己免疫性溶血性貧血
Autoimmune hemolytic anemia
62
発作性夜間ヘモグロビン尿症
Paroxysmal nocturnal hemoglobinuria
63
特発性血小板減少性紫斑病;一次性免疫性血小板減少症
Idiopathic thrombocytopenic purpura
65
原発性免疫不全症候群
Primary immunodeficiency
66
IgA腎症
IgA nephropathy
67
多発性嚢胞腎
Polycystic kidney disease
84
サルコイドーシス
Sarcoidosis
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
86
肺動脈性肺高血圧症
Pulmonary arterial hypertension
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
96
クローン病;回腸末端炎
Crohn disease
98
好酸球性消化管疾患
Eosinophilic gastrointestinal disease
137
限局性皮質異形成
Focal cortical dysplasia
157
スタージ・ウェーバー症候群
Sturge-Weber syndrome
158
結節性硬化症
Tuberous sclerosis
192
コケイン症候群
Cockayne syndrome
193
プラダー・ウィリ症候群
Prader-Willi syndrome
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
256
筋型糖原病
Muscle glycogenosis
277
リンパ管腫症/ゴーハム病
Lymphangiomatosis
278
巨大リンパ管奇形(頚部顔面病変)
Huge lymphatic malformation with cervicofacial lesion
279
巨大静脈奇形(頚部口腔咽頭びまん性病変)
Huge venous malformation with cervical, oral and pharyngeal diffuse lesion
280
巨大動静脈奇形(頚部顔面又は四肢病変)
Huge arteriovenous malformation with cervicofacial or limb lesion
281
クリッペル・トレノネー・ウェーバー症候群
Klippel-Trenaunay-Weber syndrome
283
後天性赤芽球癆
Acquired pure red cell aplasia
300
IgG4関連疾患
IgG4-related disease
331
特発性多中心性キャッスルマン病
Idiopathic multicentric castleman disease
5
MTOR
💬
5. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
51件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
51件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Everolimus
Everolimus
💬
5. MTOR
×
Name
Other Names
Everolimus
Everolimus (JAN/USAN/INN)
Afinitor (TN)
Votubia (TN)
Zortress (TN)
エベロリムス
アフィニトール
サーティカン
Everolimus
9件:
34
34
,
67
,
89
,
96
,
137
,
157
,
158
,
228
,
277
💬
5. MTOR
×
告示番号
日本語名
英語名
34
神経線維腫症
Neurofibromatosis
67
多発性嚢胞腎
Polycystic kidney disease
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
96
クローン病;回腸末端炎
Crohn disease
137
限局性皮質異形成
Focal cortical dysplasia
157
スタージ・ウェーバー症候群
Sturge-Weber syndrome
158
結節性硬化症
Tuberous sclerosis
228
閉塞性細気管支炎
Bronchiolitis obliterans
277
リンパ管腫症/ゴーハム病
Lymphangiomatosis
6
MTOR
💬
6. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
51件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
51件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Temsirolimus
Temsirolimus
💬
6. MTOR
×
Name
Other Names
Temsirolimus
Temsirolimus (JAN/USAN/INN)
Torisel (TN)
テムシロリムス
トーリセル
Temsirolimus
1件:
13
13
💬
6. MTOR
×
告示番号
日本語名
英語名
13
多発性硬化症/視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
7
JAK2
💬
7. JAK2
×
Name
Full Name
JAK2
Janus kinase 2
24件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Chemokine signaling pathway
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Signaling pathways regulating pluripotency of stem cells
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Cholinergic synapse
,
Prolactin signaling pathway
,
Adipocytokine signaling pathway
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Influenza A
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
Chemical carcinogenesis - receptor activation
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Lipid and atherosclerosis
24件:
EGFR tyrosine kinase inhibitor resistance
,
Chemokine signaling pathway
,
PI3K-Akt signaling path
...
Ruxolitinib
Ruxolitinib
💬
7. JAK2
×
Name
Other Names
Ruxolitinib
Ruxolitinib (USAN/INN)
ルキソリチニブ
Ruxolitinib
3件:
60
60
,
65
,
228
💬
7. JAK2
×
告示番号
日本語名
英語名
60
再生不良性貧血
Aplastic anemia
65
原発性免疫不全症候群
Primary immunodeficiency
228
閉塞性細気管支炎
Bronchiolitis obliterans
8
JAK2
💬
8. JAK2
×
Name
Full Name
JAK2
Janus kinase 2
24件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Chemokine signaling pathway
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Signaling pathways regulating pluripotency of stem cells
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Cholinergic synapse
,
Prolactin signaling pathway
,
Adipocytokine signaling pathway
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Influenza A
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
Chemical carcinogenesis - receptor activation
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Lipid and atherosclerosis
24件:
EGFR tyrosine kinase inhibitor resistance
,
Chemokine signaling pathway
,
PI3K-Akt signaling path
...
Tofacitinib
Tofacitinib
💬
8. JAK2
×
Name
Other Names
Tofacitinib
Tofacitinib (USAN)
Tasocitinib
トファシチニブ
タソシチニブ
Tofacitinib
15件:
11
11
,
40
,
44
,
46
,
49
,
50
,
51
,
53
,
65
,
84
,
96
,
97
,
107
,
271
,
300
💬
8. JAK2
×
告示番号
日本語名
英語名
11
重症筋無力症
Myasthenia gravis
40
高安動脈炎;大動脈炎症候群
Takayasu arteritis
44
多発血管炎性肉芽腫症;ウェゲナー肉芽腫症
Wegener granulomatosis
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
50
皮膚筋炎/多発性筋炎
Dermatomyositis
51
全身性強皮症
Scleroderma
53
シェーグレン症候群
Sjogren syndrome
65
原発性免疫不全症候群
Primary immunodeficiency
84
サルコイドーシス
Sarcoidosis
96
クローン病;回腸末端炎
Crohn disease
97
潰瘍性大腸炎
Ulcerative colitis
107
若年性特発性関節炎
Juvenile idiopathic arthritis
271
強直性脊椎炎
Ankylosing spondylitis
300
IgG4関連疾患
IgG4-related disease
9
JAK2
💬
9. JAK2
×
Name
Full Name
JAK2
Janus kinase 2
24件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Chemokine signaling pathway
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Signaling pathways regulating pluripotency of stem cells
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Cholinergic synapse
,
Prolactin signaling pathway
,
Adipocytokine signaling pathway
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Influenza A
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
Chemical carcinogenesis - receptor activation
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Lipid and atherosclerosis
24件:
EGFR tyrosine kinase inhibitor resistance
,
Chemokine signaling pathway
,
PI3K-Akt signaling path
...
Baricitinib
Baricitinib
💬
9. JAK2
×
Name
Other Names
Baricitinib
Baricitinib (JAN/USAN/INN)
Olumiant (TN)
OTHER BARICITINIB
バリシチニブ
オルミエント
Baricitinib
13件:
2
2
,
41
,
46
,
49
,
50
,
51
,
53
,
93
,
107
,
162
,
265
,
269
,
325
💬
9. JAK2
×
告示番号
日本語名
英語名
2
筋萎縮性側索硬化症
Amyotrophic lateral sclerosis
41
巨細胞性動脈炎;側頭動脈炎
Giant cell arteritis
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
50
皮膚筋炎/多発性筋炎
Dermatomyositis
51
全身性強皮症
Scleroderma
53
シェーグレン症候群
Sjogren syndrome
93
原発性胆汁性胆管炎
Primary biliary cholangitis
107
若年性特発性関節炎
Juvenile idiopathic arthritis
162
類天疱瘡(後天性表皮水疱症を含む。)
Pemphigoid
265
脂肪萎縮症
Lipodystrophy
269
化膿性無菌性関節炎・壊疽性膿皮症・アクネ症候群;PAPA症候群
Pyogenic arthritis
325
遺伝性自己炎症疾患
Hereditary autoinflammatory syndrome
10
JAK2
💬
10. JAK2
×
Name
Full Name
JAK2
Janus kinase 2
24件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Chemokine signaling pathway
,
PI3K-Akt signaling pathway
,
Necroptosis
,
Signaling pathways regulating pluripotency of stem cells
,
JAK-STAT signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Cholinergic synapse
,
Prolactin signaling pathway
,
Adipocytokine signaling pathway
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Leishmaniasis
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Influenza A
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
Chemical carcinogenesis - receptor activation
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Lipid and atherosclerosis
24件:
EGFR tyrosine kinase inhibitor resistance
,
Chemokine signaling pathway
,
PI3K-Akt signaling path
...
Peficitinib
Peficitinib
💬
10. JAK2
×
Name
Other Names
Peficitinib
Peficitinib (USAN/INN)
ペフィシチニブ
Peficitinib
1件:
46
46
💬
10. JAK2
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告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis