Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 SLC6A1 💬 [2] Synaptic vesicle cycle, GABAergic synapse Gabapentin 💬 Gabapentin [5] 6, 13, 19, 70, 298 💬
2 SLC6A2 💬 [1] Synaptic vesicle cycle Amoxapine 💬 Amoxapine [1] 46 💬
3 SLC6A2 💬 [1] Synaptic vesicle cycle Methylphenidate 💬 Methylphenidate [7] 6, 13, 34, 84, 113, 179, 206 💬
4 SLC6A2 💬 [1] Synaptic vesicle cycle Phentermine 💬 Phentermine [1] 97 💬
5 SLC6A2 💬 [1] Synaptic vesicle cycle Amitriptyline 💬 Amitriptyline [4] 78, 97, 226, 299 💬
6 SLC6A2 💬 [1] Synaptic vesicle cycle Atomoxetine 💬 Atomoxetine [4] 6, 8, 13, 17 💬
7 SLC6A2 💬 [1] Synaptic vesicle cycle Bupropion 💬 Bupropion [5] 8, 18, 21, 96, 171 💬
8 SLC6A2 💬 [1] Synaptic vesicle cycle Desipramine 💬 Desipramine [2] 120, 156 💬
9 SLC6A2 💬 [1] Synaptic vesicle cycle Doxepin 💬 Doxepin [1] 6 💬
10 SLC6A2 💬 [1] Synaptic vesicle cycle Duloxetine 💬 Duloxetine [2] 6, 13 💬
11 SLC6A2 💬 [1] Synaptic vesicle cycle Lisdexamfetamine 💬 Lisdexamfetamine [1] 13 💬
12 SLC6A2 💬 [1] Synaptic vesicle cycle Milnacipran 💬 Milnacipran [2] 46, 49 💬
13 SLC6A2 💬 [1] Synaptic vesicle cycle Nortriptyline 💬 Nortriptyline [2] 6, 226 💬
14 SLC6A2 💬 [1] Synaptic vesicle cycle Venlafaxine 💬 Venlafaxine [3] 6, 13, 46 💬
15 SLC6A2 💬 [1] Synaptic vesicle cycle Ampreloxetine 💬 Ampreloxetine [2] 6, 17 💬
16 SLC6A3 💬 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Armodafinil 💬 Armodafinil [3] 6, 13, 84 💬
17 SLC6A3 💬 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Methylphenidate 💬 Methylphenidate [7] 6, 13, 34, 84, 113, 179, 206 💬
18 SLC6A3 💬 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Phentermine 💬 Phentermine [1] 97 💬
19 SLC6A3 💬 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Bupropion 💬 Bupropion [5] 8, 18, 21, 96, 171 💬
20 SLC6A3 💬 [7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Lisdexamfetamine 💬 Lisdexamfetamine [1] 13 💬
21 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Amoxapine 💬 Amoxapine [1] 46 💬
22 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Fluoxetine 💬 Fluoxetine [6] 13, 17, 78, 86, 179, 206 💬
23 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Sertraline 💬 Sertraline [2] 6, 206 💬
24 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Paroxetine 💬 Paroxetine [4] 6, 13, 46, 85 💬
25 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Phentermine 💬 Phentermine [1] 97 💬
26 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Amitriptyline 💬 Amitriptyline [4] 78, 97, 226, 299 💬
27 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Citalopram 💬 Citalopram [7] 6, 8, 13, 18, 46, 98, 127 💬
28 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Desipramine 💬 Desipramine [2] 120, 156 💬
29 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Doxepin 💬 Doxepin [1] 6 💬
30 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Duloxetine 💬 Duloxetine [2] 6, 13 💬
31 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Escitalopram 💬 Escitalopram [4] 2, 6, 13, 46 💬
32 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬
33 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Milnacipran 💬 Milnacipran [2] 46, 49 💬
34 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Nortriptyline 💬 Nortriptyline [2] 6, 226 💬
35 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Trazodone 💬 Trazodone [1] 2 💬
36 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Venlafaxine 💬 Venlafaxine [3] 6, 13, 46 💬
37 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Vortioxetine 💬 Vortioxetine [1] 6 💬
38 SLC6A4 💬 [2] Synaptic vesicle cycle, Serotonergic synapse Ampreloxetine 💬 Ampreloxetine [2] 6, 17 💬
39 SLC18A2 💬 [7] Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism Tetrabenazine 💬 Tetrabenazine [1] 8 💬
40 SLC18A2 💬 [7] Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism Valbenazine 💬 Valbenazine [1] 8 💬
41 SLC18A2 💬 [7] Synaptic vesicle cycle, Serotonergic synapse, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Alcoholism Deutetrabenazine 💬 Deutetrabenazine [1] 8 💬
42 SNAP25 💬 [2] Synaptic vesicle cycle, Insulin secretion Botulinum toxin type A 💬 Botulinum toxin type A [14] 2, 5, 6, 7, 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬
43 SNAP25 💬 [2] Synaptic vesicle cycle, Insulin secretion Rimabotulinumtoxin B 💬 Botulinum toxin type B [4] 2, 6, 13, 51 💬
44 CACNA1B 💬 [15] MAPK signaling pathway, Calcium signaling pathway, Synaptic vesicle cycle, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Type II diabetes mellitus, Huntington disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Morphine addiction, Nicotine addiction, Chemical carcinogenesis - receptor activation Cilnidipine 💬 Cilnidipine [1] 67 💬