Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adipocytokine signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
2 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
3 Adrenergic signaling in cardiomyocytes 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
4 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
5 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
6 Alcoholic liver disease 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
7 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
8 Aldosterone synthesis and secretion 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
9 Aldosterone-regulated sodium reabsorption 💬
 [1] NR3C2 💬 Spironolactone 💬 Spironolactone [8] 46, 58, 67, 86, 113, 210, 218, 225 💬 💬
10 AMPK signaling pathway 💬
 [1] HMGCR 💬 Fluvastatin 💬 Fluvastatin [3] 79, 218, 222 💬 💬
11 AMPK signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
12 Apelin signaling pathway 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
13 Apelin signaling pathway 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
14 Apelin signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
15 Autophagy - animal 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
16 Bile secretion 💬
 [1] HMGCR 💬 Fluvastatin 💬 Fluvastatin [3] 79, 218, 222 💬 💬
17 Calcium signaling pathway 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
18 Calcium signaling pathway 💬
 [2] AGTR1, EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
19 cAMP signaling pathway 💬
 [1] EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
20 cGMP-PKG signaling pathway 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
21 cGMP-PKG signaling pathway 💬
 [2] AGTR1, EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
22 Chagas disease 💬
 [1] ACE 💬 Benazepril 💬 Benazepril [4] 49, 57, 218, 224 💬 💬
23 Chagas disease 💬
 [1] ACE 💬 Ramipril 💬 Ramipril [7] 46, 49, 66, 67, 113, 218, 257 💬 💬
24 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Paricalcitol 💬 Paricalcitol [5] 19, 66, 218, 238, 298 💬 💬
25 Circadian rhythm 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
26 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 Benazepril 💬 Benazepril [4] 49, 57, 218, 224 💬 💬
27 Coronavirus disease - COVID-19 💬
 [1] ACE 💬 Ramipril 💬 Ramipril [7] 46, 49, 66, 67, 113, 218, 257 💬 💬
28 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
29 Coronavirus disease - COVID-19 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
30 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
31 Cortisol synthesis and secretion 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
32 Cushing syndrome 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
33 Cushing syndrome 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
34 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Benazepril 💬 Benazepril [4] 49, 57, 218, 224 💬 💬
35 Diabetic cardiomyopathy 💬
 [1] ACE 💬 Ramipril 💬 Ramipril [7] 46, 49, 66, 67, 113, 218, 257 💬 💬
36 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
37 Diabetic cardiomyopathy 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
38 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] VDR 💬 Paricalcitol 💬 Paricalcitol [5] 19, 66, 218, 238, 298 💬 💬
39 Fluid shear stress and atherosclerosis 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
40 FoxO signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
41 Glucagon signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
42 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Benazepril 💬 Benazepril [4] 49, 57, 218, 224 💬 💬
43 Hypertrophic cardiomyopathy 💬
 [1] ACE 💬 Ramipril 💬 Ramipril [7] 46, 49, 66, 67, 113, 218, 257 💬 💬
44 Hypertrophic cardiomyopathy 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
45 Insulin resistance 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
46 Insulin signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
47 Longevity regulating pathway 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
48 Longevity regulating pathway - multiple species 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
49 Metabolic pathways 💬
 [1] HMGCR 💬 Fluvastatin 💬 Fluvastatin [3] 79, 218, 222 💬 💬
50 Mineral absorption 💬
 [1] VDR 💬 Paricalcitol 💬 Paricalcitol [5] 19, 66, 218, 238, 298 💬 💬
51 mTOR signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
52 Neuroactive ligand-receptor interaction 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
53 Neuroactive ligand-receptor interaction 💬
 [2] AGTR1, EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
54 Non-alcoholic fatty liver disease 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
55 Oxytocin signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
56 Parathyroid hormone synthesis, secretion and action 💬
 [1] VDR 💬 Paricalcitol 💬 Paricalcitol [5] 19, 66, 218, 238, 298 💬 💬
57 Pathways in cancer 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
58 Pathways in cancer 💬
 [2] AGTR1, EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
59 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
60 Phospholipase D signaling pathway 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
61 PI3K-Akt signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
62 Renin secretion 💬
 [1] ACE 💬 Benazepril 💬 Benazepril [4] 49, 57, 218, 224 💬 💬
63 Renin secretion 💬
 [1] ACE 💬 Ramipril 💬 Ramipril [7] 46, 49, 66, 67, 113, 218, 257 💬 💬
64 Renin secretion 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
65 Renin secretion 💬
 [2] AGTR1, EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
66 Renin-angiotensin system 💬
 [1] ACE 💬 Benazepril 💬 Benazepril [4] 49, 57, 218, 224 💬 💬
67 Renin-angiotensin system 💬
 [1] ACE 💬 Ramipril 💬 Ramipril [7] 46, 49, 66, 67, 113, 218, 257 💬 💬
68 Renin-angiotensin system 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
69 Renin-angiotensin system 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
70 Terpenoid backbone biosynthesis 💬
 [1] HMGCR 💬 Fluvastatin 💬 Fluvastatin [3] 79, 218, 222 💬 💬
71 Thermogenesis 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
72 Tight junction 💬
 [2] PRKAA1, PRKAA2 💬 Metformin 💬 Metformin [25]  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
73 Tuberculosis 💬
 [1] VDR 💬 Paricalcitol 💬 Paricalcitol [5] 19, 66, 218, 238, 298 💬 💬
74 Vascular smooth muscle contraction 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
75 Vascular smooth muscle contraction 💬
 [2] AGTR1, EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬

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