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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Alzheimer disease 💬

[1] PSMB5 💬

Bortezomib 💬

Bortezomib

[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
61	Autoimmune hemolytic anemia;AIHA;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
64	Thrombotic thrombocytopenic purpura;TTP;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

AMPK signaling pathway 💬

[1] HMGCR 💬

Simvastatin 💬

Simvastatin

[21] 6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
79	Homozygous familial hypercholesterolemia;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
94	Primary sclerosing cholangitis;PSC;
158	Tuberous sclerosis;Tuberous sclerosis complex;
160	Congenital ichthyosis;
162	Pemphigoid;
195	Noonan syndrome;
265	Lipodystrophy;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;
310	Congenital anomalies syndrome;

Amyotrophic lateral sclerosis 💬

[1] PSMB5 💬

Bortezomib 💬

Bortezomib

[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
61	Autoimmune hemolytic anemia;AIHA;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
64	Thrombotic thrombocytopenic purpura;TTP;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Bile secretion 💬

[1] HMGCR 💬

Simvastatin 💬

Simvastatin

[21] 6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
79	Homozygous familial hypercholesterolemia;
86	Pulmonary arterial hypertension;PAH;
89	Lymphangioleiomyomatosis;LAM;
94	Primary sclerosing cholangitis;PSC;
158	Tuberous sclerosis;Tuberous sclerosis complex;
160	Congenital ichthyosis;
162	Pemphigoid;
195	Noonan syndrome;
265	Lipodystrophy;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;
310	Congenital anomalies syndrome;

Complement and coagulation cascades 💬

[2] F10, F9 💬

Emicizumab 💬

Emicizumab

[1] 288 💬

Complement and coagulation cascades 💬

[1] F8 💬

Desmopressin 💬

Desmopressin

[6] 6 , 64, 72, 75, 225, 288 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
64	Thrombotic thrombocytopenic purpura;TTP;
72	Pituitary ADH secretion disorder;Inappropriate antidiuretic hormone secretion;Syndrome of inappropriate secretion of antidiuretic hormone;Inappropriate ADH syndrome;Syndrome of inappropriate ADH;
75	Cushing disease;Cushing;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;

Complement and coagulation cascades 💬

[1] PLG 💬

Tranexamic acid 💬

Tranexamic acid

[7] 46, 70, 215, 227, 274, 288, 299 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
70	Spinal stenosis;Extensive spinal canal stenosis;
215	Tetralogy of Fallot;Fallot tetralogy;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
274	Osteogenesis Imperfecta;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;
299	Cystic fibrosis;

Cytokine-cytokine receptor interaction 💬

[1] IL11RA 💬

Oprelvekin 💬

Oprelvekin

[2] 96, 288 💬

Hematopoietic cell lineage 💬

[1] IL11RA 💬

Oprelvekin 💬

Oprelvekin

[2] 96, 288 💬

Hematopoietic cell lineage 💬

[1] MS4A1 💬

Rituximab 💬

Name	Other Names
Rituximab	Rituximab (USAN/INN) Rituximab (genetical recombination) (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 1] (JAN) Rituximab (genetical recombination) [Rituximab biosimilar 2] (JAN) Rituximab-abbs Rituximab-pvvr Rituximab-arrx Rituxan (TN) Riabni (TN) Truximab (TN) RUXIENCE TRUXIMA

Rituximab

[48] 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, ...

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
19	Lysosomal storage disease;Lysosomal disease;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
35	Pemphigus;
36	Epidermolysis bullosa;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
52	Mixed connective tissue disease;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
55	Relapsing polychondritis;
56	Behcet disease;Behçet disease;BD;
60	Aplastic anemia;
61	Autoimmune hemolytic anemia;AIHA;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
64	Thrombotic thrombocytopenic purpura;TTP;
65	Primary immunodeficiency;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
83	Addison disease;Primary chronic adrenocortical insufficiency;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
94	Primary sclerosing cholangitis;PSC;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
162	Pemphigoid;
222	Primary nephrotic syndrome;
229	Autoimmune pulmonary alveolar proteinosis;Congenital pulmonary alveolar proteinosis;Hereditary pulmonary alveolar proteinosis;Pulmonary alveolar proteinosis;PAP;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
274	Osteogenesis Imperfecta;
283	Acquired pure red cell aplasia;Pure red cell aplasia;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
288	Autoimmune acquired coagulation factor deficiency;Coagulation factor deficiency;
296	Biliary atresia;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

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