Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Autophagy - animal 💬

[1] BCL2 💬

Venetoclax 💬

[1] 28 💬

2

Autophagy - animal 💬

[1] IGF1R 💬

Linsitinib 💬

[1] 232 💬

3

Autophagy - animal 💬

[1] IGF1R 💬

Mecasermin 💬

[6] 65, 78, 96, 168, 265, 299 💬

4

Autophagy - animal 💬

[1] IGF1R 💬

Teprotumumab 💬

[1] 51 💬

5

Autophagy - animal 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

[1] 34 💬

6

Autophagy - animal 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

[1] 280 💬

7

Autophagy - animal 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

[1] 34 💬

8

Autophagy - animal 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

[1] 34 💬

9

Autophagy - animal 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

10

Autophagy - animal 💬

[1] MTOR 💬

Everolimus 💬

[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬

Disease ID	Name
34	Neurofibromatosis;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
89	Lymphangioleiomyomatosis;LAM;
96	Crohn disease;Terminal ileitis;
137	Focal cortical dysplasia;FCD;
157	Sturge-Weber syndrome;Síndrome de Sturge-Weber;
158	Tuberous sclerosis;Tuberous sclerosis complex;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
277	Lymphangiomatosis;Generalized lymphatic anomaly;Gorham disease;Gorham-Stout disease;Diffuse lymphangiomatosis;Mass osteolysis;

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