Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Arachidonic acid metabolism 💬
 [1] ALOX5 💬 Oxatomide 💬 Oxatomide [1] 113 💬
2 Arachidonic acid metabolism 💬
 [1] ALOX5 💬 Zileuton 💬 Zileuton [3] 85, 160, 164 💬
3 Arachidonic acid metabolism 💬
 [3] PTGES, PTGS1, PTGS2 💬 Aceclofenac 💬 Aceclofenac [1] 46 💬
4 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬
5 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Aspirin 💬 Acetylsalicylic acid [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬
6 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬
7 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Flurbiprofen 💬 Flurbiprofen [3] 13, 21, 46 💬
8 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Ibuprofen 💬 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299 💬
9 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Indomethacin 💬 Indomethacin [3] 225, 271, 298 💬
10 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Ketoprofen 💬 Ketoprofen [1] 46 💬
11 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Ketorolac 💬 Ketorolac [2] 70, 226 💬
12 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Loxoprofen 💬 Loxoprofen [2] 46, 271 💬
13 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Naproxen 💬 Naproxen [4] 13, 46, 107, 271 💬
14 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Salsalate 💬 Salsalate [1]  5  💬
15 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Sulindac 💬 Sulindac [1] 206 💬
16 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Tolfenamic acid 💬 Tolfenamic acid [1]  5  💬
17 Arachidonic acid metabolism 💬
 [1] PTGS2 💬 Celecoxib 💬 Celecoxib [10]  2 ,  3 , 34, 46, 70, 89, 107, 161, 171, 271 💬
18 Arachidonic acid metabolism 💬
 [1] PTGS2 💬 Diflunisal 💬 Diflunisal [1] 28 💬
19 Arachidonic acid metabolism 💬
 [1] PTGS2 💬 Etodolac 💬 Etodolac [1] 46 💬
20 Arachidonic acid metabolism 💬
 [1] PTGS2 💬 Etoricoxib 💬 Etoricoxib [2] 46, 271 💬
21 Arachidonic acid metabolism 💬
 [1] PTGS2 💬 Lumiracoxib 💬 Lumiracoxib [1] 46 💬
22 Arachidonic acid metabolism 💬
 [1] PTGS2 💬 Meloxicam 💬 Meloxicam [4] 46, 49, 271, 296 💬
23 Arachidonic acid metabolism 💬
 [1] PTGS2 💬 Nimesulide 💬 Nimesulide [1] 46 💬
24 Arachidonic acid metabolism 💬
 [1] PTGS2 💬 Parecoxib 💬 Parecoxib [2] 46, 271 💬
25 Arachidonic acid metabolism 💬
 [1] PTGS2 💬 Rofecoxib 💬 Rofecoxib [1] 46 💬
26 Arachidonic acid metabolism 💬
 [1] PTGS2 💬 Valdecoxib 💬 Valdecoxib [1] 46 💬
27 Arginine and proline metabolism 💬
 [1] MAOA 💬 Moclobemide 💬 Moclobemide [1]  6  💬
28 Arginine and proline metabolism 💬
 [2] MAOA, MAOB 💬 Iproniazid 💬 Iproniazid [1]  6  💬
29 Arginine and proline metabolism 💬
 [2] MAOA, MAOB 💬 Phenelzine 💬 Phenelzine [1]  6  💬
30 Arginine and proline metabolism 💬
 [2] MAOA, MAOB 💬 Phentermine 💬 Phentermine [1] 97 💬
31 Arginine and proline metabolism 💬
 [1] MAOB 💬 Rasagiline 💬 Rasagiline [6]  2 ,  5 ,  6 , 17, 58, 66 💬
32 Arginine and proline metabolism 💬
 [1] MAOB 💬 Rasagiline tartrate 💬 Rasagiline [6]  2 ,  5 ,  6 , 17, 58, 66 💬
33 Arginine and proline metabolism 💬
 [1] MAOB 💬 Safinamide 💬 Safinamide [2]  6 , 17 💬
34 Arginine and proline metabolism 💬
 [1] MAOB 💬 Selegiline 💬 Selegiline [1]  6  💬
35 Arginine and proline metabolism 💬
 [1] ODC1 💬 Eflornithine 💬 Eflornithine [1] 65 💬
36 Arginine biosynthesis 💬
 [1] CPS1 💬 Carglumic acid 💬 Carglumic acid [3] 245, 246, 251 💬
37 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
38 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
39 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
40 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
41 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
42 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
43 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
44 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
45 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
46 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
47 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
48 Arrhythmogenic right ventricular cardiomyopathy 💬
 [2] CACNA2D1, CACNA2D2 💬 Mirogabalin 💬 Mirogabalin [1] 70 💬
49 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 Gabapentin 💬 Gabapentin [5]  6 , 13, 19, 70, 298 💬
50 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4 💬 Pregabalin 💬 Pregabalin [5] 13, 36, 46, 70, 298 💬
51 Arrhythmogenic right ventricular cardiomyopathy 💬
 [1] DMD 💬 Casimersen 💬 Casimersen [1] 113 💬
52 Arrhythmogenic right ventricular cardiomyopathy 💬
 [1] DMD 💬 Drisapersen 💬 Drisapersen [1] 113 💬
53 Arrhythmogenic right ventricular cardiomyopathy 💬
 [1] DMD 💬 Eteplirsen 💬 Eteplirsen [1] 113 💬
54 Arrhythmogenic right ventricular cardiomyopathy 💬
 [1] DMD 💬 Golodirsen 💬 Golodirsen [1] 113 💬
55 Arrhythmogenic right ventricular cardiomyopathy 💬
 [1] DMD 💬 Viltolarsen 💬 Viltolarsen [1] 113 💬
56 Arrhythmogenic right ventricular cardiomyopathy 💬
 [1] ITGA4 💬 Firategrast 💬 Firategrast [1] 13 💬
57 Arrhythmogenic right ventricular cardiomyopathy 💬
 [1] ITGA4 💬 Natalizumab 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
58 Arrhythmogenic right ventricular cardiomyopathy 💬
 [2] ITGA4, ITGB7 💬 Abrilumab 💬 Abrilumab [2] 96, 97 💬
59 Arrhythmogenic right ventricular cardiomyopathy 💬
 [2] ITGA4, ITGB7 💬 Vedolizumab 💬 Vedolizumab [3] 94, 96, 97 💬
60 Arrhythmogenic right ventricular cardiomyopathy 💬
 [1] ITGB7 💬 Etrolizumab 💬 Etrolizumab [2] 96, 97 💬
61 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬
62 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬
63 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Bisoprolol 💬 Bisoprolol [4] 58, 67, 86, 113 💬
64 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Celiprolol 💬 Celiprolol [1] 168 💬
65 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Dobutamine 💬 Dobutamine [4] 57, 58, 86, 215 💬
66 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Esmolol 💬 Esmolol [1] 58 💬
67 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Metoprolol 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬
68 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬
69 Chemical carcinogenesis - receptor activation 💬
 [2] ADRB1, ADRB2 💬 Carvedilol 💬 Carvedilol [4] 57, 86, 113, 210 💬
70 Chemical carcinogenesis - receptor activation 💬
 [2] ADRB1, ADRB2 💬 Nadolol 💬 Nadolol [1]  6  💬
71 Chemical carcinogenesis - receptor activation 💬
 [2] ADRB1, ADRB2 💬 Timolol 💬 Timolol [2] 157, 227 💬
72 Chemical carcinogenesis - receptor activation 💬
 [2] ADRB1, ADRB2 💬 Timolol 💬 Timolol [2] 157, 227 💬
73 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Dipivefrin 💬 Dipivefrin [1]  6  💬
74 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Droxidopa 💬 Droxidopa [5]  5 ,  6 , 17, 169, 170 💬
75 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Ephedrine 💬 Ephedrine [1] 11 💬
76 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Epinephrine 💬 Epinephrine [3] 46, 70, 96 💬
77 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Noradrenaline 💬 Norepinephrine [2] 22, 296 💬
78 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬
79 Chemical carcinogenesis - receptor activation 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Pseudoephedrine 💬 Pseudoephedrine [1] 17 💬
80 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Clenbuterol 💬 Clenbuterol [5]  1 ,  2 ,  6 , 13, 256 💬
81 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Formoterol 💬 Formoterol [3] 85, 228, 299 💬
82 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Isoxsuprine 💬 Isoxsuprine [1] 13 💬
83 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Levosalbutamol 💬 Levosalbutamol [1] 49 💬
84 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Albuterol 💬 Salbutamol [12]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬
85 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Salmeterol 💬 Salmeterol [1] 299 💬
86 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Terbutaline 💬 Terbutaline [1] 118 💬
87 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Tulobuterol 💬 Tulobuterol [1]  6  💬
88 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB3 💬 Mirabegron 💬 Mirabegron [4]  6 , 13, 53, 226 💬
89 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Calusterone 💬 Calusterone [1]  2  💬
90 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Flutamide 💬 Flutamide [1] 81 💬
91 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Nandrolone 💬 Nandrolone [2] 60, 85 💬
92 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Nandrolone decanoate 💬 Nandrolone decanoate [2] 60, 85 💬
93 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Oxandrolone 💬 Oxandrolone [2] 211, 285 💬
94 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Stanozolol 💬 Stanozolol [1] 60 💬
95 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Testosterone 💬 Testosterone [8]  1 ,  2 ,  3 , 13, 60, 76, 78, 113 💬
96 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Testosterone decanoate 💬 Testosterone decanoate [1] 113 💬
97 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Testosterone enanthate 💬 Testosterone enanthate [1] 113 💬
98 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Testosterone phenylpropionate 💬 Testosterone phenylpropionate [1] 113 💬
99 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Testosterone propionate 💬 Testosterone propionate [1] 113 💬
100 Chemical carcinogenesis - receptor activation 💬
 [1] AR 💬 Testosterone undecanoate 💬 Testosterone undecanoate [2] 13, 60 💬
101 Chemical carcinogenesis - receptor activation 💬
 [3] AR, ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
102 Chemical carcinogenesis - receptor activation 💬
 [3] AR, ESR1, PGR 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
103 Chemical carcinogenesis - receptor activation 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [1] 28 💬
104 Chemical carcinogenesis - receptor activation 💬
 [5] CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬
105 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬
106 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬
107 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬
108 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬
109 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬
110 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬
111 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬
112 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬
113 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
114 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬
115 Chemical carcinogenesis - receptor activation 💬
 [6] CHRNA3, CHRNA4, CHRNA7, CHRNA9, CHRNB2, CHRNB4 💬 Nicotine 💬 Nicotine [3]  6 , 13, 84 💬
116 Chemical carcinogenesis - receptor activation 💬
 [2] CHRNA4, CHRNB2 💬 Varenicline 💬 Varenicline [3]  6 , 18, 53 💬
117 Chemical carcinogenesis - receptor activation 💬
 [1] EGFR 💬 Cetuximab 💬 Cetuximab [2] 51, 86 💬
118 Chemical carcinogenesis - receptor activation 💬
 [1] EGFR 💬 Erlotinib 💬 Erlotinib [1] 94 💬
119 Chemical carcinogenesis - receptor activation 💬
 [1] EGFR 💬 Gefitinib 💬 Gefitinib [1] 75 💬
120 Chemical carcinogenesis - receptor activation 💬
 [1] EGFR 💬 Icotinib 💬 Icotinib [1] 34 💬
121 Chemical carcinogenesis - receptor activation 💬
 [1] EGFR 💬 Lapatinib 💬 Lapatinib [3] 34, 74, 75 💬
122 Chemical carcinogenesis - receptor activation 💬
 [1] EGFR 💬 Neratinib 💬 Neratinib [1] 34 💬
123 Chemical carcinogenesis - receptor activation 💬
 [1] EGFR 💬 Tesevatinib 💬 Tesevatinib [1] 67 💬
124 Chemical carcinogenesis - receptor activation 💬
 [1] ESR1 💬 Ethinyl estradiol 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
125 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬
126 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
127 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬
128 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
129 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬
130 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬
131 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬
132 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬
133 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬
134 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬
135 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬
136 Chemical carcinogenesis - receptor activation 💬
 [2] ESR1, PGR 💬 Desogestrel 💬 Desogestrel [1] 230 💬
137 Chemical carcinogenesis - receptor activation 💬
 [1] JAK2 💬 Baricitinib 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
138 Chemical carcinogenesis - receptor activation 💬
 [1] JAK2 💬 Peficitinib 💬 Peficitinib [1] 46 💬
139 Chemical carcinogenesis - receptor activation 💬
 [1] JAK2 💬 Ruxolitinib 💬 Ruxolitinib [3] 60, 65, 228 💬
140 Chemical carcinogenesis - receptor activation 💬
 [1] JAK2 💬 Tofacitinib 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
141 Chemical carcinogenesis - receptor activation 💬
 [2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬
142 Chemical carcinogenesis - receptor activation 💬
 [2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬
143 Chemical carcinogenesis - receptor activation 💬
 [2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬
144 Chemical carcinogenesis - receptor activation 💬
 [2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬
145 Chemical carcinogenesis - receptor activation 💬
 [2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬
146 Chemical carcinogenesis - receptor activation 💬
 [1] MTOR 💬 Everolimus 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
147 Chemical carcinogenesis - receptor activation 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
148 Chemical carcinogenesis - receptor activation 💬
 [1] MTOR 💬 Temsirolimus 💬 Temsirolimus [1] 13 💬
149 Chemical carcinogenesis - receptor activation 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
150 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Dydrogesterone 💬 Dydrogesterone [1] 13 💬
151 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Levonorgestrel 💬 Levonorgestrel [1] 13 💬
152 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Medroxyprogesterone acetate 💬 Medroxyprogesterone acetate [8] 13, 35, 46, 49, 50, 51, 60, 107 💬
153 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Megestrol acetate 💬 Megestrol acetate [1] 76 💬
154 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Mifepristone 💬 Mifepristone [1] 75 💬
155 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Nomegestrol 💬 Nomegestrol [1] 13 💬
156 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Nomegestrol acetate 💬 Nomegestrol acetate [1] 13 💬
157 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Norethindrone 💬 Norethisterone [4] 13, 46, 49, 299 💬
158 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Norgestimate 💬 Norgestimate [1] 299 💬
159 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Progesterone 💬 Progesterone [2] 76, 299 💬
160 Chemical carcinogenesis - receptor activation 💬
 [1] PGR 💬 Ulipristal 💬 Ulipristal [1] 10 💬
161 Chemical carcinogenesis - receptor activation 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
162 Chemical carcinogenesis - receptor activation 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
163 Chemical carcinogenesis - receptor activation 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
164 Chemical carcinogenesis - receptor activation 💬
 [1] PPARA 💬 Bezafibrate 💬 Bezafibrate [7] 20, 93, 94, 160, 296, 316, 324 💬
165 Chemical carcinogenesis - receptor activation 💬
 [1] PPARA 💬 Elafibranor 💬 Elafibranor [2] 93, 94 💬
166 Chemical carcinogenesis - receptor activation 💬
 [1] PPARA 💬 Fenofibrate 💬 Fenofibrate [6]  8 , 79, 93, 94, 97, 265 💬
167 Chemical carcinogenesis - receptor activation 💬
 [1] PPARA 💬 Pemafibrate 💬 Pemafibrate [1] 93 💬
168 Chemical carcinogenesis - receptor activation 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
169 Chemical carcinogenesis - receptor activation 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
170 Chemical carcinogenesis - receptor activation 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
171 Chemical carcinogenesis - receptor activation 💬
 [3] RXRA, RXRB, RXRG 💬 Acitretin 💬 Acitretin [1] 37 💬
172 Chemical carcinogenesis - receptor activation 💬
 [3] RXRA, RXRB, RXRG 💬 Alitretinoin 💬 Alitretinoin [1] 49 💬
173 Chemical carcinogenesis - receptor activation 💬
 [3] RXRA, RXRB, RXRG 💬 Bexarotene 💬 Bexarotene [2] 13, 75 💬
174 Chemical carcinogenesis - receptor activation 💬
 [1] SRC 💬 Bosutinib 💬 Bosutinib [2]  2 , 67 💬
175 Chemical carcinogenesis - receptor activation 💬
 [1] SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
176 Chemical carcinogenesis - receptor activation 💬
 [1] SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬
177 Chemical carcinogenesis - receptor activation 💬
 [1] SRC 💬 Saracatinib 💬 Saracatinib [3]  6 , 89, 272 💬
178 Chemical carcinogenesis - receptor activation 💬
 [1] TNFSF11 💬 Denosumab 💬 Denosumab [8] 46, 50, 70, 93, 95, 96, 274, 299 💬
179 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Alfacalcidol 💬 Alfacalcidol [8] 41, 46, 49, 50, 96, 107, 235, 238 💬
180 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Calcifediol 💬 Calcifediol [2] 113, 299 💬
181 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Calcipotriene 💬 Calcipotriol [2] 36, 51 💬
182 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Calcitriol 💬 Calcitriol [9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
183 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Cholecalciferol 💬 Cholecalciferol [24]  6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬
184 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Dihydrotachysterol 💬 Dihydrotachysterol [2]  6 , 85 💬
185 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Eldecalcitol 💬 Eldecalcitol [1] 46 💬
186 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Ergocalciferol 💬 Ergocalciferol [6] 46, 49, 84, 96, 97, 299 💬
187 Chemical carcinogenesis - receptor activation 💬
 [1] VDR 💬 Paricalcitol 💬 Paricalcitol [5] 19, 66, 218, 238, 298 💬
188 Chemical carcinogenesis - receptor activation 💬
 [1] VEGFA 💬 Aflibercept 💬 Aflibercept [2] 90, 166 💬
189 Chemical carcinogenesis - receptor activation 💬
 [1] VEGFA 💬 Bevacizumab 💬 Bevacizumab [6] 13, 34, 85, 87, 227, 280 💬
190 Chemical carcinogenesis - receptor activation 💬
 [1] VEGFA 💬 Ranibizumab 💬 Ranibizumab [4] 34, 166, 227, 301 💬
191 Glycosaminoglycan degradation 💬
 [1] ARSB 💬 Galsulfase 💬 Galsulfase [1] 19 💬
192 Lysosome 💬
 [1] ARSB 💬 Galsulfase 💬 Galsulfase [1] 19 💬
193 Metabolic pathways 💬
 [1] ARSB 💬 Galsulfase 💬 Galsulfase [1] 19 💬
194 Oocyte meiosis 💬
 [1] AR 💬 Calusterone 💬 Calusterone [1]  2  💬
195 Oocyte meiosis 💬
 [1] AR 💬 Flutamide 💬 Flutamide [1] 81 💬
196 Oocyte meiosis 💬
 [1] AR 💬 Nandrolone 💬 Nandrolone [2] 60, 85 💬
197 Oocyte meiosis 💬
 [1] AR 💬 Nandrolone decanoate 💬 Nandrolone decanoate [2] 60, 85 💬
198 Oocyte meiosis 💬
 [1] AR 💬 Oxandrolone 💬 Oxandrolone [2] 211, 285 💬
199 Oocyte meiosis 💬
 [1] AR 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
200 Oocyte meiosis 💬
 [1] AR 💬 Stanozolol 💬 Stanozolol [1] 60 💬
201 Oocyte meiosis 💬
 [1] AR 💬 Testosterone 💬 Testosterone [8]  1 ,  2 ,  3 , 13, 60, 76, 78, 113 💬
202 Oocyte meiosis 💬
 [1] AR 💬 Testosterone decanoate 💬 Testosterone decanoate [1] 113 💬
203 Oocyte meiosis 💬
 [1] AR 💬 Testosterone enanthate 💬 Testosterone enanthate [1] 113 💬
204 Oocyte meiosis 💬
 [1] AR 💬 Testosterone phenylpropionate 💬 Testosterone phenylpropionate [1] 113 💬
205 Oocyte meiosis 💬
 [1] AR 💬 Testosterone propionate 💬 Testosterone propionate [1] 113 💬
206 Oocyte meiosis 💬
 [1] AR 💬 Testosterone undecanoate 💬 Testosterone undecanoate [2] 13, 60 💬
207 Oocyte meiosis 💬
 [2] AR, PGR 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
208 Pathways in cancer 💬
 [1] AR 💬 Calusterone 💬 Calusterone [1]  2  💬
209 Pathways in cancer 💬
 [1] AR 💬 Flutamide 💬 Flutamide [1] 81 💬
210 Pathways in cancer 💬
 [1] AR 💬 Nandrolone 💬 Nandrolone [2] 60, 85 💬
211 Pathways in cancer 💬
 [1] AR 💬 Nandrolone decanoate 💬 Nandrolone decanoate [2] 60, 85 💬
212 Pathways in cancer 💬
 [1] AR 💬 Oxandrolone 💬 Oxandrolone [2] 211, 285 💬
213 Pathways in cancer 💬
 [1] AR 💬 Stanozolol 💬 Stanozolol [1] 60 💬
214 Pathways in cancer 💬
 [1] AR 💬 Testosterone 💬 Testosterone [8]  1 ,  2 ,  3 , 13, 60, 76, 78, 113 💬
215 Pathways in cancer 💬
 [1] AR 💬 Testosterone decanoate 💬 Testosterone decanoate [1] 113 💬
216 Pathways in cancer 💬
 [1] AR 💬 Testosterone enanthate 💬 Testosterone enanthate [1] 113 💬
217 Pathways in cancer 💬
 [1] AR 💬 Testosterone phenylpropionate 💬 Testosterone phenylpropionate [1] 113 💬
218 Pathways in cancer 💬
 [1] AR 💬 Testosterone propionate 💬 Testosterone propionate [1] 113 💬
219 Pathways in cancer 💬
 [1] AR 💬 Testosterone undecanoate 💬 Testosterone undecanoate [2] 13, 60 💬
220 Pathways in cancer 💬
 [2] AR, ESR1 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
221 Pathways in cancer 💬
 [3] AR, ESR1, ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
222 Prostate cancer 💬
 [1] AR 💬 Calusterone 💬 Calusterone [1]  2  💬
223 Prostate cancer 💬
 [1] AR 💬 Danazol 💬 Danazol [5] 60, 63, 64, 65, 285 💬
224 Prostate cancer 💬
 [1] AR 💬 Flutamide 💬 Flutamide [1] 81 💬
225 Prostate cancer 💬
 [1] AR 💬 Nandrolone 💬 Nandrolone [2] 60, 85 💬
226 Prostate cancer 💬
 [1] AR 💬 Nandrolone decanoate 💬 Nandrolone decanoate [2] 60, 85 💬
227 Prostate cancer 💬
 [1] AR 💬 Oxandrolone 💬 Oxandrolone [2] 211, 285 💬
228 Prostate cancer 💬
 [1] AR 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
229 Prostate cancer 💬
 [1] AR 💬 Stanozolol 💬 Stanozolol [1] 60 💬
230 Prostate cancer 💬
 [1] AR 💬 Testosterone 💬 Testosterone [8]  1 ,  2 ,  3 , 13, 60, 76, 78, 113 💬
231 Prostate cancer 💬
 [1] AR 💬 Testosterone decanoate 💬 Testosterone decanoate [1] 113 💬
232 Prostate cancer 💬
 [1] AR 💬 Testosterone enanthate 💬 Testosterone enanthate [1] 113 💬
233 Prostate cancer 💬
 [1] AR 💬 Testosterone phenylpropionate 💬 Testosterone phenylpropionate [1] 113 💬
234 Prostate cancer 💬
 [1] AR 💬 Testosterone propionate 💬 Testosterone propionate [1] 113 💬
235 Prostate cancer 💬
 [1] AR 💬 Testosterone undecanoate 💬 Testosterone undecanoate [2] 13, 60 💬
236 Rheumatoid arthritis 💬
 [5] CCL2, IL1A, IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
237 Rheumatoid arthritis 💬
 [2] CD80, CD86 💬 Abatacept 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
238 Rheumatoid arthritis 💬
 [2] CD80, CD86 💬 Belatacept 💬 Belatacept [1] 46 💬
239 Rheumatoid arthritis 💬
 [1] CSF2 💬 Otilimab 💬 Otilimab [1] 46 💬
240 Rheumatoid arthritis 💬
 [1] CTLA4 💬 Ipilimumab 💬 Ipilimumab [1] 159 💬
241 Rheumatoid arthritis 💬
 [1] CTLA4 💬 Tremelimumab 💬 Tremelimumab [1] 96 💬
242 Rheumatoid arthritis 💬
 [1] FLT1 💬 Axitinib 💬 Axitinib [1] 34 💬
243 Rheumatoid arthritis 💬
 [1] FLT1 💬 Cediranib 💬 Cediranib [1] 34 💬
244 Rheumatoid arthritis 💬
 [1] FLT1 💬 Nintedanib 💬 Nintedanib [5] 51, 85, 89, 227, 228 💬
245 Rheumatoid arthritis 💬
 [1] FLT1 💬 Sunitinib 💬 Sunitinib [2] 28, 34 💬
246 Rheumatoid arthritis 💬
 [1] IFNG 💬 Emapalumab 💬 Emapalumab [3] 49, 65, 107 💬
247 Rheumatoid arthritis 💬
 [1] IFNG 💬 Fontolizumab 💬 Fontolizumab [1] 46 💬
248 Rheumatoid arthritis 💬
 [1] IL17A 💬 Bimekizumab 💬 Bimekizumab [3] 46, 97, 271 💬
249 Rheumatoid arthritis 💬
 [1] IL17A 💬 Ixekizumab 💬 Ixekizumab [8] 36, 37, 46, 107, 160, 162, 269, 271 💬
250 Rheumatoid arthritis 💬
 [1] IL17A 💬 Secukinumab 💬 Secukinumab [8] 13, 37, 41, 46, 107, 160, 269, 271 💬
251 Rheumatoid arthritis 💬
 [2] IL17A, TNFSF13B 💬 Tibulizumab 💬 Tibulizumab [1] 53 💬
252 Rheumatoid arthritis 💬
 [1] IL1A 💬 Bermekimab 💬 Bermekimab [1] 51 💬
253 Rheumatoid arthritis 💬
 [2] IL1A, IL1B 💬 Rilonacept 💬 Rilonacept [4] 51, 106, 107, 266 💬
254 Rheumatoid arthritis 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
255 Rheumatoid arthritis 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬
256 Rheumatoid arthritis 💬
 [1] IL23A 💬 Brazikumab 💬 Brazikumab [2] 96, 97 💬
257 Rheumatoid arthritis 💬
 [1] IL23A 💬 Guselkumab 💬 Guselkumab [5] 37, 41, 51, 96, 97 💬
258 Rheumatoid arthritis 💬
 [1] IL23A 💬 Mirikizumab 💬 Mirikizumab [3] 37, 96, 97 💬
259 Rheumatoid arthritis 💬
 [1] IL23A 💬 Risankizumab 💬 Risankizumab [4] 37, 96, 97, 271 💬
260 Rheumatoid arthritis 💬
 [1] IL23A 💬 Tildrakizumab 💬 Tildrakizumab [2] 162, 271 💬
261 Rheumatoid arthritis 💬
 [1] IL23A 💬 Ustekinumab 💬 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
262 Rheumatoid arthritis 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
263 Rheumatoid arthritis 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
264 Rheumatoid arthritis 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
265 Rheumatoid arthritis 💬
 [2] IL6, TNF 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
266 Rheumatoid arthritis 💬
 [1] ITGAL 💬 Efalizumab 💬 Efalizumab [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 💬
267 Rheumatoid arthritis 💬
 [1] LTB 💬 Baminercept 💬 Baminercept [4] 13, 46, 53, 97 💬
268 Rheumatoid arthritis 💬
 [3] TGFB1, TGFB2, TGFB3 💬 Fresolimumab 💬 Fresolimumab [3] 51, 85, 222 💬
269 Rheumatoid arthritis 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
270 Rheumatoid arthritis 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
271 Rheumatoid arthritis 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
272 Rheumatoid arthritis 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
273 Rheumatoid arthritis 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
274 Rheumatoid arthritis 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
275 Rheumatoid arthritis 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
276 Rheumatoid arthritis 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
277 Rheumatoid arthritis 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
278 Rheumatoid arthritis 💬
 [1] TNFSF11 💬 Denosumab 💬 Denosumab [8] 46, 50, 70, 93, 95, 96, 274, 299 💬
279 Rheumatoid arthritis 💬
 [2] TNFSF13, TNFSF13B 💬 Atacicept 💬 Atacicept [4] 13, 46, 49, 66 💬
280 Rheumatoid arthritis 💬
 [1] TNFSF13B 💬 Belimumab 💬 Belimumab [13] 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300 💬
281 Rheumatoid arthritis 💬
 [1] TNFSF13B 💬 Tabalumab 💬 Tabalumab [2] 46, 49 💬
282 Rheumatoid arthritis 💬
 [1] VEGFA 💬 Aflibercept 💬 Aflibercept [2] 90, 166 💬
283 Rheumatoid arthritis 💬
 [1] VEGFA 💬 Bevacizumab 💬 Bevacizumab [6] 13, 34, 85, 87, 227, 280 💬
284 Rheumatoid arthritis 💬
 [1] VEGFA 💬 Ranibizumab 💬 Ranibizumab [4] 34, 166, 227, 301 💬

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