Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Cytokine-cytokine receptor interaction 💬

[1] ACVR2A 💬

Sotatercept 💬

[2] 86, 284 💬

2

Cytokine-cytokine receptor interaction 💬

[2] ACVR2A, ACVR2B 💬

Bimagrumab 💬

[1] 15 💬

3

Cytokine-cytokine receptor interaction 💬

[1] ACVR2B 💬

Luspatercept 💬

[1] 60 💬

4

Cytokine-cytokine receptor interaction 💬

[6] CCL2, IL10, IL1A, IL1B, IL6, TNF 💬

Pirfenidone 💬

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

5

Cytokine-cytokine receptor interaction 💬

[2] CCR2, CCR5 💬

Cenicriviroc 💬

[1] 94 💬

6

Cytokine-cytokine receptor interaction 💬

[1] CCR4 💬

Mogamulizumab 💬

[1] 26 💬

7

Cytokine-cytokine receptor interaction 💬

[1] CCR5 💬

[2] 46, 84 💬

8

Cytokine-cytokine receptor interaction 💬

[1] CD4 💬

Zanolimumab 💬

[1] 46 💬

9

Cytokine-cytokine receptor interaction 💬

[1] CD40 💬

Bleselumab 💬

[1] 222 💬

10

Cytokine-cytokine receptor interaction 💬

[1] CD40 💬

[2] 49, 53 💬

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