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No.	KEGG PATHWAY	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	FoxO signaling pathway 💬	[1] BRAF 💬	Dabrafenib 💬	Dabrafenib	[1] 34 💬 💬
2	FoxO signaling pathway 💬	[2] BRAF, RAF1 💬	Sorafenib 💬	Sorafenib	[2] 34, 86 💬 💬
3	FoxO signaling pathway 💬	[1] EGFR 💬	Cetuximab 💬	Cetuximab	[2] 51, 86 💬 💬
4	FoxO signaling pathway 💬	[1] EGFR 💬	Erlotinib 💬	Erlotinib	[1] 94 💬 💬
5	FoxO signaling pathway 💬	[1] EGFR 💬	Gefitinib 💬	Gefitinib	[1] 75 💬 💬
6	FoxO signaling pathway 💬	[1] EGFR 💬	Icotinib 💬	Icotinib	[1] 34 💬 💬
7	FoxO signaling pathway 💬	[1] EGFR 💬	Lapatinib 💬	Lapatinib	[3] 34, 74, 75 💬 💬
8	FoxO signaling pathway 💬	[1] EGFR 💬	Neratinib 💬	Neratinib	[1] 34 💬 💬
9	FoxO signaling pathway 💬	[1] EGFR 💬	Tesevatinib 💬	Tesevatinib	[1] 67 💬 💬
10	FoxO signaling pathway 💬	[1] IGF1R 💬	Linsitinib 💬	Linsitinib	[1] 232 💬 💬
11	FoxO signaling pathway 💬	[1] IGF1R 💬	Mecasermin 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 💬
12	FoxO signaling pathway 💬	[1] IGF1R 💬	Teprotumumab 💬	Teprotumumab	[1] 51 💬 💬
13	FoxO signaling pathway 💬	[2] IL10, IL6 💬	Pirfenidone 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬
14	FoxO signaling pathway 💬	[1] IL6 💬	Olokizumab 💬	Olokizumab	[2] 46, 96 💬 💬
15	FoxO signaling pathway 💬	[1] IL6 💬	Pomalidomide 💬	Pomalidomide	[5] 28, 51, 85, 227, 331 💬 💬
16	FoxO signaling pathway 💬	[1] IL6 💬	Siltuximab 💬	Siltuximab	[2] 28, 331 💬 💬
17	FoxO signaling pathway 💬	[1] IL6 💬	Sirukumab 💬	Sirukumab	[2] 41, 46 💬 💬
18	FoxO signaling pathway 💬	[1] INSR 💬	Insulin detemir 💬	Insulin detemir	[1] 299 💬 💬
19	FoxO signaling pathway 💬	[1] INSR 💬	Insulin glargine 💬	Insulin glargine	[1] 299 💬 💬
20	FoxO signaling pathway 💬	[1] INSR 💬	Insulin human 💬	Insulin human	[2] 96, 156 💬 💬
21	FoxO signaling pathway 💬	[2] MAP2K1, MAP2K2 💬	Binimetinib 💬	Binimetinib	[1] 34 💬 💬
22	FoxO signaling pathway 💬	[2] MAP2K1, MAP2K2 💬	Cobimetinib 💬	Cobimetinib	[1] 280 💬 💬
23	FoxO signaling pathway 💬	[2] MAP2K1, MAP2K2 💬	Mirdametinib 💬	Mirdametinib	[1] 34 💬 💬
24	FoxO signaling pathway 💬	[2] MAP2K1, MAP2K2 💬	Selumetinib 💬	Selumetinib	[1] 34 💬 💬
25	FoxO signaling pathway 💬	[2] MAP2K1, MAP2K2 💬	Trametinib 💬	Trametinib	[4] 2 , 34, 279, 280 💬 💬
26	FoxO signaling pathway 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	Losmapimod 💬	Losmapimod	[2] 113, 222 💬 💬
27	FoxO signaling pathway 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	Neflamapimod 💬	Neflamapimod	[1] 8 💬 💬
28	FoxO signaling pathway 💬	[1] PIK3CA 💬	Alpelisib 💬	Alpelisib	[1] 138 💬 💬
29	FoxO signaling pathway 💬	[3] PIK3CA, PIK3CB, PIK3CD 💬	Leniolisib 💬	Leniolisib	[2] 53, 65 💬 💬
30	FoxO signaling pathway 💬	[1] PIK3CD 💬	Parsaclisib 💬	Parsaclisib	[3] 35, 53, 61 💬 💬
31	FoxO signaling pathway 💬	[1] PLK1 💬	Rigosertib 💬	Rigosertib	[1] 36 💬 💬
32	FoxO signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	Metformin 💬	Metformin	[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
33	FoxO signaling pathway 💬	[1] S1PR1 💬	Cenerimod 💬	Cenerimod	[1] 49 💬 💬
34	FoxO signaling pathway 💬	[1] S1PR1 💬	Fingolimod 💬	Fingolimod	[3] 13, 14, 156 💬 💬
35	FoxO signaling pathway 💬	[1] S1PR1 💬	Ponesimod 💬	Ponesimod	[1] 13 💬 💬
36	FoxO signaling pathway 💬	[1] S1PR1 💬	Siponimod 💬	Siponimod	[2] 13, 50 💬 💬
37	FoxO signaling pathway 💬	[2] S1PR1, S1PR4 💬	Amiselimod 💬	Amiselimod	[1] 97 💬 💬
38	FoxO signaling pathway 💬	[2] S1PR1, S1PR4 💬	Etrasimod 💬	Etrasimod	[3] 96, 97, 98 💬 💬
39	FoxO signaling pathway 💬	[2] S1PR1, S1PR4 💬	Ozanimod 💬	Ozanimod	[3] 13, 96, 97 💬 💬
40	FoxO signaling pathway 💬	[3] TGFB1, TGFB2, TGFB3 💬	Fresolimumab 💬	Fresolimumab	[3] 51, 85, 222 💬 💬