Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Regulation of actin cytoskeleton 💬

[1] BRAF 💬

Dabrafenib 💬

[1] 34 💬

2

Regulation of actin cytoskeleton 💬

[3] BRAF, PDGFRB, RAF1 💬

[2] 34, 86 💬

3

Regulation of actin cytoskeleton 💬

[1] C5 💬

Crovalimab 💬

[2] 62, 109 💬

4

Regulation of actin cytoskeleton 💬

[1] C5 💬

Eculizumab 💬

[7] 11, 13, 14, 61, 62, 109, 222 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
61	Autoimmune hemolytic anemia;AIHA;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
109	Atypical hemolytic uremic syndrome;aHUS;
222	Primary nephrotic syndrome;

5

Regulation of actin cytoskeleton 💬

[1] C5 💬

[3] 62, 109, 162 💬

6

Regulation of actin cytoskeleton 💬

[1] C5 💬

[2] 11, 62 💬

7

Regulation of actin cytoskeleton 💬

[1] C5 💬

Ravulizumab 💬

[7] 2 , 11, 13, 50, 62, 66, 109 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
50	Dermatomyositis;Polymyositis;
62	Paroxysmal nocturnal hemoglobinuria;PNH;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
109	Atypical hemolytic uremic syndrome;aHUS;

8

Regulation of actin cytoskeleton 💬

[1] C5 💬

Vilobelimab 💬

[3] 43, 44, 269 💬

Disease ID	Name
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;

9

Regulation of actin cytoskeleton 💬

[1] C5 💬

Zilucoplan 💬

[3] 2 , 11, 62 💬

10

Regulation of actin cytoskeleton 💬

[5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬

Name	Full Name
CHRM1	cholinergic receptor muscarinic 1
CHRM2	cholinergic receptor muscarinic 2
CHRM3	cholinergic receptor muscarinic 3
CHRM4	cholinergic receptor muscarinic 4
CHRM5	cholinergic receptor muscarinic 5

[2] 2 , 299 💬

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