Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	TUBB3	[10] Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, H ...	D00570	Colchicine	[7] 2, 42, 46, 56, 93, 210, 266
2	TUBB4A	[10] Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, H ...	D00570	Colchicine	[7] 2, 42, 46, 56, 93, 210, 266
3	TUBB4B	[10] Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, H ...	D00570	Colchicine	[7] 2, 42, 46, 56, 93, 210, 266
4	TUBB	[10] Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, H ...	D00570	Colchicine	[7] 2, 42, 46, 56, 93, 210, 266
5	TUBB8	[10] Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, H ...	D00570	Colchicine	[7] 2, 42, 46, 56, 93, 210, 266
6	TUBB2B	[10] Phagosome, Gap junction, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, H ...	D00570	Colchicine	[7] 2, 42, 46, 56, 93, 210, 266
7	IL1A	[21] MAPK signaling pathway, Cytokine-cytokine receptor interaction, Necroptosis, Cellular senescenc ...	D06635	Rilonacept	[4] 51, 106, 107, 266
8	IL1B	[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...	D06635	Rilonacept	[4] 51, 106, 107, 266
9	IL1B	[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...	D09315	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
10	IL1R1	[13] MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, O ...	D02934	Anakinra	[18] 2, 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299

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