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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
指定難病告示番号
1
ADRB2
💬
1. ADRB2
×
Name
Full Name
ADRB2
adrenoceptor beta 2
9件:
Calcium signaling pathway
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
cAMP signaling pathway
,
Neuroactive ligand-receptor interaction
,
Adrenergic signaling in cardiomyocytes
,
Regulation of lipolysis in adipocytes
,
Renin secretion
,
Salivary secretion
,
Chemical carcinogenesis - receptor activation
9件:
Calcium signaling pathway
,
cGMP-PKG signaling pathway
,
cAMP signaling pathway
,
Neuroactive ligan
...
Albuterol
Albuterol
💬
1. ADRB2
×
Name
Other Names
Albuterol
Albuterol (USP)
Salbutamol
Proventil (TN)
アルブテロール
サルブタモール
Salbutamol
12件:
3
3
,
11
,
12
,
13
,
49
,
85
,
86
,
89
,
111
,
113
,
256
,
299
💬
1. ADRB2
×
告示番号
日本語名
英語名
3
脊髄性筋萎縮症
Spinal muscular atrophy
11
重症筋無力症
Myasthenia gravis
12
先天性筋無力症候群
Congenital myasthenic syndrome
13
多発性硬化症/視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
49
全身性エリテマトーデス
Systemic lupus erythematosus
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
86
肺動脈性肺高血圧症
Pulmonary arterial hypertension
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
111
先天性ミオパチー
Congenital myopathy
113
筋ジストロフィー
Muscular dystrophy
256
筋型糖原病
Muscle glycogenosis
299
嚢胞性線維症;膵囊胞線維症
Cystic fibrosis
2
CYP19A1
💬
2. CYP19A1
×
Name
Full Name
CYP19A1
cytochrome P450 family 19 subfamily A member 1
3件:
Steroid hormone biosynthesis
Steroid hormone biosynthesis
,
Metabolic pathways
,
Ovarian steroidogenesis
Letrozole
Letrozole
💬
2. CYP19A1
×
Name
Other Names
Letrozole
Letrozole (JAN/USP/INN)
Femara (TN)
レトロゾール
フェマーラ
Letrozole
2件:
81
81
,
89
💬
2. CYP19A1
×
告示番号
日本語名
英語名
81
先天性副腎皮質酵素欠損症
Congenital adrenal hyperplasia
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
3
FGFR1
💬
3. FGFR1
×
Name
Full Name
FGFR1
fibroblast growth factor receptor 1
16件:
MAPK signaling pathway
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
PI3K-Akt signaling pathway
,
Adherens junction
,
Signaling pathways regulating pluripotency of stem cells
,
Thermogenesis
,
Regulation of actin cytoskeleton
,
Parathyroid hormone synthesis, secretion and action
,
Pathways in cancer
,
Proteoglycans in cancer
,
Prostate cancer
,
Melanoma
,
Breast cancer
,
Central carbon metabolism in cancer
16件:
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathwa
...
Nintedanib
Nintedanib
💬
3. FGFR1
×
Name
Other Names
Nintedanib
Nintedanib (USAN/INN)
Ofev (TN)
ニンテダニブ
Nintedanib
5件:
51
51
,
85
,
89
,
227
,
228
💬
3. FGFR1
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
227
オスラー病;遺伝性出血性末梢血管拡張症
Osler disease
228
閉塞性細気管支炎
Bronchiolitis obliterans
4
FGFR3
💬
4. FGFR3
×
Name
Full Name
FGFR3
fibroblast growth factor receptor 3
13件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Signaling pathways regulating pluripotency of stem cells
,
Regulation of actin cytoskeleton
,
Pathways in cancer
,
MicroRNAs in cancer
,
Bladder cancer
,
Central carbon metabolism in cancer
13件:
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1
...
Nintedanib
Nintedanib
💬
4. FGFR3
×
Name
Other Names
Nintedanib
Nintedanib (USAN/INN)
Ofev (TN)
ニンテダニブ
Nintedanib
5件:
51
51
,
85
,
89
,
227
,
228
💬
4. FGFR3
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
227
オスラー病;遺伝性出血性末梢血管拡張症
Osler disease
228
閉塞性細気管支炎
Bronchiolitis obliterans
5
FGFR2
💬
5. FGFR2
×
Name
Full Name
FGFR2
fibroblast growth factor receptor 2
13件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Signaling pathways regulating pluripotency of stem cells
,
Regulation of actin cytoskeleton
,
Pathways in cancer
,
Prostate cancer
,
Gastric cancer
,
Central carbon metabolism in cancer
13件:
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1
...
Nintedanib
Nintedanib
💬
5. FGFR2
×
Name
Other Names
Nintedanib
Nintedanib (USAN/INN)
Ofev (TN)
ニンテダニブ
Nintedanib
5件:
51
51
,
85
,
89
,
227
,
228
💬
5. FGFR2
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
227
オスラー病;遺伝性出血性末梢血管拡張症
Osler disease
228
閉塞性細気管支炎
Bronchiolitis obliterans
6
FLT1
💬
6. FLT1
×
Name
Full Name
FLT1
fms related receptor tyrosine kinase 1
9件:
MAPK signaling pathway
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Transcriptional misregulation in cancer
,
Rheumatoid arthritis
9件:
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
...
Nintedanib
Nintedanib
💬
6. FLT1
×
Name
Other Names
Nintedanib
Nintedanib (USAN/INN)
Ofev (TN)
ニンテダニブ
Nintedanib
5件:
51
51
,
85
,
89
,
227
,
228
💬
6. FLT1
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
227
オスラー病;遺伝性出血性末梢血管拡張症
Osler disease
228
閉塞性細気管支炎
Bronchiolitis obliterans
7
FLT4
💬
7. FLT4
×
Name
Full Name
FLT4
fms related receptor tyrosine kinase 4
8件:
MAPK signaling pathway
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Pathways in cancer
,
Breast cancer
8件:
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
...
Nintedanib
Nintedanib
💬
7. FLT4
×
Name
Other Names
Nintedanib
Nintedanib (USAN/INN)
Ofev (TN)
ニンテダニブ
Nintedanib
5件:
51
51
,
85
,
89
,
227
,
228
💬
7. FLT4
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
227
オスラー病;遺伝性出血性末梢血管拡張症
Osler disease
228
閉塞性細気管支炎
Bronchiolitis obliterans
8
MTOR
💬
8. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
51件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
51件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Sirolimus
Sirolimus
💬
8. MTOR
×
Name
Other Names
Sirolimus
Sirolimus (JAN/USAN/INN)
Rapamune (TN)
Rapamycin (TN)
FYARRO
HYFTOR
シロリムス
ラパリムス
Sirolimus
40件:
2
2
,
13
,
15
,
17
,
19
,
34
,
35
,
36
,
46
,
49
,
51
,
53
,
60
,
61
,
62
,
63
,
65
,
66
,
67
,
84
,
85
,
86
,
89
,
96
,
98
,
137
,
157
,
158
,
192
,
193
,
222
,
256
,
277
,
278
,
279
,
280
,
281
,
283
,
300
,
331
💬
40件:
2
,
13
,
15
,
17
,
19
,
34
,
35
,
36
,
46
,
49
,
51
,
53
,
60
,
61
,
62
,
63
,
65
,
66
,
67
,
84
,
85
,
86
,
89
,
96
, ...
8. MTOR
×
告示番号
日本語名
英語名
2
筋萎縮性側索硬化症
Amyotrophic lateral sclerosis
13
多発性硬化症/視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
15
封入体筋炎
Inclusion body myositis
17
多系統萎縮症
Multiple system atrophy
19
ライソゾーム病
Lysosomal storage disease
34
神経線維腫症
Neurofibromatosis
35
天疱瘡
Pemphigus
36
表皮水疱症
Epidermolysis bullosa
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
51
全身性強皮症
Scleroderma
53
シェーグレン症候群
Sjogren syndrome
60
再生不良性貧血
Aplastic anemia
61
自己免疫性溶血性貧血
Autoimmune hemolytic anemia
62
発作性夜間ヘモグロビン尿症
Paroxysmal nocturnal hemoglobinuria
63
特発性血小板減少性紫斑病;一次性免疫性血小板減少症
Idiopathic thrombocytopenic purpura
65
原発性免疫不全症候群
Primary immunodeficiency
66
IgA腎症
IgA nephropathy
67
多発性嚢胞腎
Polycystic kidney disease
84
サルコイドーシス
Sarcoidosis
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
86
肺動脈性肺高血圧症
Pulmonary arterial hypertension
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
96
クローン病;回腸末端炎
Crohn disease
98
好酸球性消化管疾患
Eosinophilic gastrointestinal disease
137
限局性皮質異形成
Focal cortical dysplasia
157
スタージ・ウェーバー症候群
Sturge-Weber syndrome
158
結節性硬化症
Tuberous sclerosis
192
コケイン症候群
Cockayne syndrome
193
プラダー・ウィリ症候群
Prader-Willi syndrome
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
256
筋型糖原病
Muscle glycogenosis
277
リンパ管腫症/ゴーハム病
Lymphangiomatosis
278
巨大リンパ管奇形(頚部顔面病変)
Huge lymphatic malformation with cervicofacial lesion
279
巨大静脈奇形(頚部口腔咽頭びまん性病変)
Huge venous malformation with cervical, oral and pharyngeal diffuse lesion
280
巨大動静脈奇形(頚部顔面又は四肢病変)
Huge arteriovenous malformation with cervicofacial or limb lesion
281
クリッペル・トレノネー・ウェーバー症候群
Klippel-Trenaunay-Weber syndrome
283
後天性赤芽球癆
Acquired pure red cell aplasia
300
IgG4関連疾患
IgG4-related disease
331
特発性多中心性キャッスルマン病
Idiopathic multicentric castleman disease
9
MTOR
💬
9. MTOR
×
Name
Full Name
MTOR
mechanistic target of rapamycin kinase
51件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1 signaling pathway
,
Phospholipase D signaling pathway
,
Autophagy - other
,
Autophagy - animal
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Cellular senescence
,
Apelin signaling pathway
,
Neutrophil extracellular trap formation
,
JAK-STAT signaling pathway
,
Th17 cell differentiation
,
Thermogenesis
,
Insulin signaling pathway
,
Thyroid hormone signaling pathway
,
Adipocytokine signaling pathway
,
Type II diabetes mellitus
,
Insulin resistance
,
Growth hormone synthesis, secretion and action
,
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Shigellosis
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Human immunodeficiency virus 1 infection
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Colorectal cancer
,
Pancreatic cancer
,
Glioma
,
Prostate cancer
,
Acute myeloid leukemia
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
51件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
ErbB signaling pathway
,
HIF-1
...
Everolimus
Everolimus
💬
9. MTOR
×
Name
Other Names
Everolimus
Everolimus (JAN/USAN/INN)
Afinitor (TN)
Votubia (TN)
Zortress (TN)
エベロリムス
アフィニトール
サーティカン
Everolimus
9件:
34
34
,
67
,
89
,
96
,
137
,
157
,
158
,
228
,
277
💬
9. MTOR
×
告示番号
日本語名
英語名
34
神経線維腫症
Neurofibromatosis
67
多発性嚢胞腎
Polycystic kidney disease
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
96
クローン病;回腸末端炎
Crohn disease
137
限局性皮質異形成
Focal cortical dysplasia
157
スタージ・ウェーバー症候群
Sturge-Weber syndrome
158
結節性硬化症
Tuberous sclerosis
228
閉塞性細気管支炎
Bronchiolitis obliterans
277
リンパ管腫症/ゴーハム病
Lymphangiomatosis
10
ABL1
💬
10. ABL1
×
Name
Full Name
ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase
11件:
ErbB signaling pathway
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signaling pathway
,
Pathogenic Escherichia coli infection
,
Pathways in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
Chronic myeloid leukemia
,
Viral myocarditis
11件:
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signalin
...
Imatinib
Imatinib
💬
10. ABL1
×
Name
Other Names
Imatinib
Imatinib (INN)
Glamox (TN)
イマチニブ
Imatinib
12件:
13
13
,
28
,
34
,
35
,
46
,
51
,
85
,
86
,
87
,
88
,
89
,
162
💬
10. ABL1
×
告示番号
日本語名
英語名
13
多発性硬化症/視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
28
全身性アミロイドーシス
Systemic amyloidosis
34
神経線維腫症
Neurofibromatosis
35
天疱瘡
Pemphigus
46
悪性関節リウマチ
Malignant rheumatoid arthritis
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
86
肺動脈性肺高血圧症
Pulmonary arterial hypertension
87
肺静脈閉塞症/肺毛細血管腫症
Pulmonary veno-occlusive disease
88
慢性血栓塞栓性肺高血圧症;特発性慢性肺血栓塞栓症(肺高血圧型)
Chronic thromboembolic pulmonary hypertension
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
162
類天疱瘡(後天性表皮水疱症を含む。)
Pemphigoid