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No.
KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
指定難病告示番号
1
MAPK14
💬
1. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
62件:
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
62件:
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
1. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
ロスマピモド
Losmapimod
2件:
113
113
,
222
💬
1. MAPK14
×
告示番号
日本語名
英語名
113
筋ジストロフィー
Muscular dystrophy
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
2
MAPK14
💬
2. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
62件:
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
62件:
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
2. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
ネフラマピモド
Neflamapimod
1件:
8
8
💬
2. MAPK14
×
告示番号
日本語名
英語名
8
ハンチントン病
Huntington disease
3
NQO1
💬
3. NQO1
×
Name
Full Name
NQO1
NAD(P)H quinone dehydrogenase 1
7件:
Ubiquinone and other terpenoid-quinone biosynthesis
Ubiquinone and other terpenoid-quinone biosynthesis
,
Metabolic pathways
,
Biosynthesis of cofactors
,
Pathways in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
Hepatocellular carcinoma
,
Fluid shear stress and atherosclerosis
7件:
Ubiquinone and other terpenoid-quinone biosynthesis
,
Metabolic pathways
,
Biosynthesis of cofacto
...
Warfarin
Warfarin
💬
3. NQO1
×
Name
Other Names
Warfarin
Warfarin (INN)
Warfarine
Choice (TN)
ワルファリン
Warfarin
11件:
6
6
,
8
,
13
,
19
,
46
,
49
,
66
,
85
,
86
,
88
,
91
💬
3. NQO1
×
告示番号
日本語名
英語名
6
パーキンソン病
Parkinson disease
8
ハンチントン病
Huntington disease
13
多発性硬化症／視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
19
ライソゾーム病
Lysosomal storage disease
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
66
IgA腎症
IgA nephropathy
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
86
肺動脈性肺高血圧症
Pulmonary arterial hypertension
88
慢性血栓塞栓性肺高血圧症;特発性慢性肺血栓塞栓症（肺高血圧型）
Chronic thromboembolic pulmonary hypertension
91
バッド・キアリ症候群
Budd-Chiari syndrome
4
EGFR
💬
4. EGFR
×
Name
Full Name
EGFR
epidermal growth factor receptor
48件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Adherens junction
,
Gap junction
,
JAK-STAT signaling pathway
,
Regulation of actin cytoskeleton
,
GnRH signaling pathway
,
Estrogen signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Epithelial cell signaling in Helicobacter pylori infection
,
Shigellosis
,
Hepatitis C
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Bladder cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
48件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Gefitinib
Gefitinib
💬
4. EGFR
×
Name
Other Names
Gefitinib
Gefitinib (JP18/USAN/INN)
Iressa (TN)
ゲフィチニブ
イレッサ
Gefitinib
1件:
75
75
💬
4. EGFR
×
告示番号
日本語名
英語名
75
クッシング病
Cushing disease
5
EGFR
💬
5. EGFR
×
Name
Full Name
EGFR
epidermal growth factor receptor
48件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Adherens junction
,
Gap junction
,
JAK-STAT signaling pathway
,
Regulation of actin cytoskeleton
,
GnRH signaling pathway
,
Estrogen signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Epithelial cell signaling in Helicobacter pylori infection
,
Shigellosis
,
Hepatitis C
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Bladder cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
48件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Cetuximab
Cetuximab
💬
5. EGFR
×
Name
Other Names
Cetuximab
Cetuximab (USAN/INN)
Cetuximab (genetical recombination) (JAN)
Erbitux (TN)
セツキシマブ
アービタックス
Cetuximab
2件:
51
51
,
86
💬
5. EGFR
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
86
肺動脈性肺高血圧症
Pulmonary arterial hypertension
6
EGFR
💬
6. EGFR
×
Name
Full Name
EGFR
epidermal growth factor receptor
48件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Adherens junction
,
Gap junction
,
JAK-STAT signaling pathway
,
Regulation of actin cytoskeleton
,
GnRH signaling pathway
,
Estrogen signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Epithelial cell signaling in Helicobacter pylori infection
,
Shigellosis
,
Hepatitis C
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Bladder cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
48件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Erlotinib
Erlotinib
💬
6. EGFR
×
Name
Other Names
Erlotinib
Erlotinib (INN)
エルロチニブ
Erlotinib
1件:
94
94
💬
6. EGFR
×
告示番号
日本語名
英語名
94
原発性硬化性胆管炎
Primary sclerosing cholangitis
7
EGFR
💬
7. EGFR
×
Name
Full Name
EGFR
epidermal growth factor receptor
48件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Adherens junction
,
Gap junction
,
JAK-STAT signaling pathway
,
Regulation of actin cytoskeleton
,
GnRH signaling pathway
,
Estrogen signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Epithelial cell signaling in Helicobacter pylori infection
,
Shigellosis
,
Hepatitis C
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Bladder cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
48件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Lapatinib
Lapatinib
💬
7. EGFR
×
Name
Other Names
Lapatinib
Lapatinib (INN)
ラパチニブ
Lapatinib
3件:
34
34
,
74
,
75
💬
7. EGFR
×
告示番号
日本語名
英語名
34
神経線維腫症
Neurofibromatosis
74
下垂体性PRL分泌亢進症
Prolactin secreting pituitary adenoma
75
クッシング病
Cushing disease
8
EGFR
💬
8. EGFR
×
Name
Full Name
EGFR
epidermal growth factor receptor
48件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Adherens junction
,
Gap junction
,
JAK-STAT signaling pathway
,
Regulation of actin cytoskeleton
,
GnRH signaling pathway
,
Estrogen signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Epithelial cell signaling in Helicobacter pylori infection
,
Shigellosis
,
Hepatitis C
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Bladder cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
48件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Neratinib
Neratinib
💬
8. EGFR
×
Name
Other Names
Neratinib
Neratinib (USAN/INN)
ネラチニブ
Neratinib
1件:
34
34
💬
8. EGFR
×
告示番号
日本語名
英語名
34
神経線維腫症
Neurofibromatosis
9
EGFR
💬
9. EGFR
×
Name
Full Name
EGFR
epidermal growth factor receptor
48件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Adherens junction
,
Gap junction
,
JAK-STAT signaling pathway
,
Regulation of actin cytoskeleton
,
GnRH signaling pathway
,
Estrogen signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Epithelial cell signaling in Helicobacter pylori infection
,
Shigellosis
,
Hepatitis C
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Bladder cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
48件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Icotinib
Icotinib
💬
9. EGFR
×
Name
Other Names
Icotinib
Icotinib
イコチニブ
Icotinib
1件:
34
34
💬
9. EGFR
×
告示番号
日本語名
英語名
34
神経線維腫症
Neurofibromatosis
10
EGFR
💬
10. EGFR
×
Name
Full Name
EGFR
epidermal growth factor receptor
48件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Adherens junction
,
Gap junction
,
JAK-STAT signaling pathway
,
Regulation of actin cytoskeleton
,
GnRH signaling pathway
,
Estrogen signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Epithelial cell signaling in Helicobacter pylori infection
,
Shigellosis
,
Hepatitis C
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Bladder cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
48件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Tesevatinib
Tesevatinib
💬
10. EGFR
×
Name
Other Names
Tesevatinib
Tesevatinib (USAN/INN)
テセバチニブ
Tesevatinib
1件:
67
67
💬
10. EGFR
×
告示番号
日本語名
英語名
67
多発性嚢胞腎
Polycystic kidney disease