Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Adipocytokine signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Alcoholic liver disease 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

AMPK signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Apelin signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Autophagy - animal 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Circadian rhythm 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Fluid shear stress and atherosclerosis 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

FoxO signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Glucagon signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Hypertrophic cardiomyopathy 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Insulin resistance 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Insulin signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Longevity regulating pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Longevity regulating pathway - multiple species 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

mTOR signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Non-alcoholic fatty liver disease 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Oxytocin signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

PI3K-Akt signaling pathway 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Thermogenesis 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;

Tight junction 💬

[2] PRKAA1, PRKAA2 💬

Metformin 💬

Metformin

[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
60	Aplastic anemia;
65	Primary immunodeficiency;
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
77	Growth hormone secreting pituitary adenoma;Pituitary growth hormone secretion hyperthyroidism;
81	Congenital adrenal hyperplasia;CAH;Congenital adrenal enzyme deficiency;Congenial adrenal cortex enzyme deficiency;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
127	Frontotemporal lobar degeneration;
158	Tuberous sclerosis;Tuberous sclerosis complex;
206	Fragile X syndrome;
218	Alport syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
233	Wolfram syndrome;Diabetes Insipidus, Diabetes mellitus, optic atrophy, and deafness syndrome;DIDMOAD syndrome;
265	Lipodystrophy;
285	Fanconi anemia;
299	Cystic fibrosis;
301	Macular dystrophy;