Target Gene/Pathway Pathway / Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

1

Fluid shear stress and atherosclerosis 💬

[1] ACVR2A 💬

Sotatercept 💬

[2] 86, 284 💬

2

Fluid shear stress and atherosclerosis 💬

[2] ACVR2A, ACVR2B 💬

Bimagrumab 💬

[1] 15 💬

3

Fluid shear stress and atherosclerosis 💬

[1] ACVR2B 💬

Luspatercept 💬

[1] 60 💬

4

Fluid shear stress and atherosclerosis 💬

[1] BCL2 💬

Venetoclax 💬

[1] 28 💬

5

Fluid shear stress and atherosclerosis 💬

[4] CCL2, IL1A, IL1B, TNF 💬

Pirfenidone 💬

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

6

Fluid shear stress and atherosclerosis 💬

[1] HMOX1 💬

Stannsoporfin 💬

[1] 254 💬

7

Fluid shear stress and atherosclerosis 💬

[1] IFNG 💬

Emapalumab 💬

[3] 49, 65, 107 💬

8

Fluid shear stress and atherosclerosis 💬

[1] IFNG 💬

Fontolizumab 💬

[1] 46 💬

9

Fluid shear stress and atherosclerosis 💬

[1] IL1A 💬

Bermekimab 💬

[1] 51 💬

10

Fluid shear stress and atherosclerosis 💬

[2] IL1A, IL1B 💬

Rilonacept 💬

[4] 51, 106, 107, 266 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
106	Cryopyrin-associated periodic syndrome;Cryopyrin associated periodic fever syndrome;
107	Juvenile idiopathic arthritis;JIA;
266	Familial mediterranean fever;

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