Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	CTLA4	3件: Cell adhesion molecules, T cell receptor signaling pathway, Rheumatoid arthritis	D04603	Ipilimumab	1件: 159
2	CTLA4	3件: Cell adhesion molecules, T cell receptor signaling pathway, Rheumatoid arthritis	D06657	Tremelimumab	1件: 96
3	CD274	2件: Cell adhesion molecules, PD-L1 expression and PD-1 checkpoint pathway in cancer	D10773	Atezolizumab	1件: 85
4	CD274	2件: Cell adhesion molecules, PD-L1 expression and PD-1 checkpoint pathway in cancer	D10808	Durvalumab	1件: 85
5	ITGA4	13件: PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, ...	D06590	Firategrast	1件: 13
6	ITGA4	13件: PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, ...	D06886	Natalizumab	6件: 13, 15, 25, 46, 63, 96
7	ITGA4	13件: PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, ...	D08083	Vedolizumab	3件: 94, 96, 97
8	ITGA4	13件: PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, ...	D10540	Abrilumab	2件: 96, 97
9	ITGAL	12件: Rap1 signaling pathway, Cell adhesion molecules, Neutrophil extracellular trap formation, Natur ...	D03959	Efalizumab	9件: 11, 13, 37, 46, 49, 53, 61, 95, 96
10	ITGB7	10件: PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, ...	D08083	Vedolizumab	3件: 94, 96, 97

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