Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 HDAC6 4件: Neutrophil extracellular trap formation, Amyotrophic lateral sclerosis, Alcoholism, Viral carcinogenesis D06320 Vorinostat 2件: 75, 96
2 HDAC5 5件: Apelin signaling pathway, Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, MicroRNAs in cancer D06320 Vorinostat 2件: 75, 96
3 HRH3 1件: Neuroactive ligand-receptor interaction D09870 Bavisant 1件: 6
4 HRH3 1件: Neuroactive ligand-receptor interaction D10749 Pitolisant 3件: 6, 113, 193
5 HTR3C 2件: Serotonergic synapse, Taste transduction D00283 Clozapine 1件: 6
6 HTR3C 2件: Serotonergic synapse, Taste transduction D00456 Ondansetron 3件: 6, 97, 107
7 HTR3C 2件: Serotonergic synapse, Taste transduction D07867 Dolasetron 1件: 46
8 HTR3C 2件: Serotonergic synapse, Taste transduction D10184 Vortioxetine 1件: 6
9 HTR3D 2件: Serotonergic synapse, Taste transduction D00283 Clozapine 1件: 6
10 HTR3D 2件: Serotonergic synapse, Taste transduction D00456 Ondansetron 3件: 6, 97, 107
11 HTR3D 2件: Serotonergic synapse, Taste transduction D07867 Dolasetron 1件: 46
12 HTR3D 2件: Serotonergic synapse, Taste transduction D10184 Vortioxetine 1件: 6
13 HTR3E 2件: Serotonergic synapse, Taste transduction D00283 Clozapine 1件: 6
14 HTR3E 2件: Serotonergic synapse, Taste transduction D00456 Ondansetron 3件: 6, 97, 107
15 HTR3E 2件: Serotonergic synapse, Taste transduction D07867 Dolasetron 1件: 46
16 HTR3E 2件: Serotonergic synapse, Taste transduction D10184 Vortioxetine 1件: 6
17 HCRTR1 1件: Neuroactive ligand-receptor interaction D10082 Suvorexant 3件: 5, 6, 13
18 HCRTR2 1件: Neuroactive ligand-receptor interaction D10082 Suvorexant 3件: 5, 6, 13
19 HDAC1 15件: Cell cycle, Longevity regulating pathway - multiple species, Notch signaling pathway, Neutrophil extracellular trap formation, Thyroid hormone signaling pathway, Huntington disease, Amphetamine addiction, Alcoholism, Human papillomavirus infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, MicroRNAs in cancer, Chronic myeloid leukemia D06320 Vorinostat 2件: 75, 96
20 HDAC2 15件: Cell cycle, Longevity regulating pathway - multiple species, Notch signaling pathway, Neutrophil extracellular trap formation, Thyroid hormone signaling pathway, Huntington disease, Amphetamine addiction, Alcoholism, Human papillomavirus infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, MicroRNAs in cancer, Chronic myeloid leukemia D06320 Vorinostat 2件: 75, 96
21 HMGCR 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D00359 Lovastatin 11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
22 HMGCR 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D00434 Simvastatin 21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
23 HMGCR 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D07474 Atorvastatin 19件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299
24 HMGCR 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D07983 Fluvastatin 3件: 79, 218, 222
25 HMGCR 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D08410 Pravastatin 9件: 13, 46, 49, 67, 79, 96, 164, 265, 333
26 HMGCR 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion D08492 Rosuvastatin 11件: 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
27 HMOX1 10件: Porphyrin metabolism, Metabolic pathways, HIF-1 signaling pathway, Ferroptosis, Mineral absorption, Pathways in cancer, MicroRNAs in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis D05922 Stannsoporfin 1件: 254
28 HMOX2 3件: Porphyrin metabolism, Metabolic pathways, Mineral absorption D05922 Stannsoporfin 1件: 254
29 HPD 5件: Ubiquinone and other terpenoid-quinone biosynthesis, Tyrosine metabolism, Phenylalanine metabolism, Metabolic pathways, Biosynthesis of cofactors D05177 Nitisinone 3件: 6, 164, 241
30 HPRT1 4件: Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism D00161 Mercaptopurine 4件: 65, 96, 97, 164
31 HPRT1 4件: Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism D04931 Mercaptopurine 4件: 65, 96, 97, 164
32 HPRT1 4件: Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism D08603 Tioguanine 2件: 13, 37
33 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine 1件: 254
34 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00300 Diphenhydramine 8件: 11, 13, 49, 51, 70, 86, 222, 256
35 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00364 Loratadine 4件: 13, 46, 89, 98
36 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00454 Olanzapine 2件: 2, 8
37 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00494 Promethazine 1件: 96
38 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D03535 Clemastine 1件: 13
39 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D03693 Desloratadine 1件: 13
40 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07398 Chlorpheniramine 1件: 14
41 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07402 Levocetirizine 1件: 61
42 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07407 Rupatadine 1件: 46
43 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07662 Cetirizine 4件: 13, 28, 35, 300
44 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07803 Dexchlorpheniramine 2件: 13, 49
45 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07875 Doxepin 1件: 6
46 HRH1 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07958 Fexofenadine 2件: 13, 46
47 HRH2 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gastric acid secretion D00295 Cimetidine 2件: 2, 254
48 HRH2 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gastric acid secretion D00318 Famotidine 6件: 6, 46, 61, 86, 98, 107
49 HRH2 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gastric acid secretion D00422 Ranitidine 2件: 13, 65
50 HTR1A 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction D01164 Aripiprazole 2件: 6, 206
51 HTR1A 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction D07593 Buspirone 2件: 6, 51
52 HTR1A 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction D09397 Pardoprunox 1件: 6
53 HTR1A 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction D09997 Cariprazine 1件: 21
54 HTR1A 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction D10184 Vortioxetine 1件: 6
55 HTR1B 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction D00415 Zolmitriptan 1件: 6
56 HTR1D 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction D00415 Zolmitriptan 1件: 6
57 HTR1D 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction D07945 Fenfluramine 4件: 140, 144, 145, 149
58 HTR2A 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine 1件: 254
59 HTR2A 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00274 Cisapride 1件: 13
60 HTR2A 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00283 Clozapine 1件: 6
61 HTR2A 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00426 Risperidone 5件: 8, 156, 179, 187, 206
62 HTR2A 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00454 Olanzapine 2件: 2, 8
63 HTR2A 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D01164 Aripiprazole 2件: 6, 206
64 HTR2A 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D02092 Cisapride 1件: 13
65 HTR2A 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D02666 Iloperidone 1件: 6
66 HTR2A 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D07945 Fenfluramine 4件: 140, 144, 145, 149
67 HTR2A 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D08456 Quetiapine 2件: 6, 13
68 HTR2A 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D08626 Trazodone 1件: 2
69 HTR2A 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D09645 Nelotanserin 1件: 6
70 HTR2A 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D09997 Cariprazine 1件: 21
71 HTR2B 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine 1件: 254
72 HTR2B 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00454 Olanzapine 2件: 2, 8
73 HTR2B 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D02666 Iloperidone 1件: 6
74 HTR2B 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D08626 Trazodone 1件: 2
75 HTR2C 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine 1件: 254
76 HTR2C 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00283 Clozapine 1件: 6
77 HTR2C 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00454 Olanzapine 2件: 2, 8
78 HTR2C 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D02578 Agomelatine 1件: 6
79 HTR2C 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D02666 Iloperidone 1件: 6
80 HTR2C 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D07945 Fenfluramine 4件: 140, 144, 145, 149
81 HTR2C 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D08626 Trazodone 1件: 2
82 HTR3A 2件: Serotonergic synapse, Taste transduction D00274 Cisapride 1件: 13
83 HTR3A 2件: Serotonergic synapse, Taste transduction D00283 Clozapine 1件: 6
84 HTR3A 2件: Serotonergic synapse, Taste transduction D00456 Ondansetron 3件: 6, 97, 107
85 HTR3A 2件: Serotonergic synapse, Taste transduction D02092 Cisapride 1件: 13
86 HTR3A 2件: Serotonergic synapse, Taste transduction D07867 Dolasetron 1件: 46
87 HTR3A 2件: Serotonergic synapse, Taste transduction D10184 Vortioxetine 1件: 6
88 HTR4 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse D00274 Cisapride 1件: 13
89 HTR4 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse D02092 Cisapride 1件: 13
90 HTR4 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse D08236 Mosapride 1件: 96
91 HTR4 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse D09205 Prucalopride 3件: 13, 51, 96
92 HTR4 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse D09693 Velusetrag 1件: 99
93 HTR6 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse D00454 Olanzapine 2件: 2, 8
94 HDAC7 3件: Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis D06320 Vorinostat 2件: 75, 96
95 HAO1 4件: Glyoxylate and dicarboxylate metabolism, Metabolic pathways, Carbon metabolism, Peroxisome D11925 Lumasiran 1件: 234
96 HDAC8 4件: Cell cycle, Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis D06320 Vorinostat 2件: 75, 96
97 HDAC11 3件: Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis D06320 Vorinostat 2件: 75, 96
98 HDAC10 3件: Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis D06320 Vorinostat 2件: 75, 96
99 HDAC3 4件: Neutrophil extracellular trap formation, Thyroid hormone signaling pathway, Alcoholism, Viral carcinogenesis D06320 Vorinostat 2件: 75, 96
100 HTR3B 2件: Serotonergic synapse, Taste transduction D00283 Clozapine 1件: 6
101 HTR3B 2件: Serotonergic synapse, Taste transduction D00456 Ondansetron 3件: 6, 97, 107
102 HTR3B 2件: Serotonergic synapse, Taste transduction D07867 Dolasetron 1件: 46
103 HTR3B 2件: Serotonergic synapse, Taste transduction D10184 Vortioxetine 1件: 6
104 HDAC9 3件: Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis D06320 Vorinostat 2件: 75, 96
105 HDAC4 5件: Apelin signaling pathway, Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, MicroRNAs in cancer D06320 Vorinostat 2件: 75, 96