Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 DDC 9件: Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Dopaminergic synapse, Cocaine addiction, Amphetamine addiction, Alcoholism D00558 Carbidopa 7件: 6, 13, 17, 90, 140, 164, 201
2 DDC 9件: Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Dopaminergic synapse, Cocaine addiction, Amphetamine addiction, Alcoholism D03082 Benserazide 1件: 6
3 DHFR 5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, Antifolate resistance D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
4 DHODH 3件: Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors D00749 Leflunomide 12件: 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300
5 DHODH 3件: Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors D10172 Teriflunomide 3件: 13, 25, 26
6 DMD 4件: Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Viral myocarditis D09900 Eteplirsen 1件: 113
7 DMD 4件: Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Viral myocarditis D10114 Drisapersen 1件: 113
8 DMD 4件: Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Viral myocarditis D11528 Viltolarsen 1件: 113
9 DMD 4件: Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Viral myocarditis D11707 Golodirsen 1件: 113
10 DMD 4件: Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Viral myocarditis D11988 Casimersen 1件: 113
11 DNMT1 3件: Cysteine and methionine metabolism, Metabolic pathways, MicroRNAs in cancer D03665 Decitabine 3件: 13, 60, 63
12 DNMT3A 3件: Cysteine and methionine metabolism, Metabolic pathways, MicroRNAs in cancer D03665 Decitabine 3件: 13, 60, 63
13 DNMT3B 3件: Cysteine and methionine metabolism, Metabolic pathways, MicroRNAs in cancer D03665 Decitabine 3件: 13, 60, 63
14 DPEP1 - D07698 Cilastatin 2件: 60, 299
15 DPP4 1件: Protein digestion and absorption D08516 Sitagliptin 4件: 6, 75, 233, 299
16 DPP4 1件: Protein digestion and absorption D08996 Saxagliptin 1件: 299
17 DRD1 10件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Morphine addiction, Alcoholism D00059 Levodopa 6件: 6, 17, 90, 140, 164, 201
18 DRD1 10件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Morphine addiction, Alcoholism D01044 Flupentixol 1件: 97
19 DRD1 10件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Morphine addiction, Alcoholism D07460 Apomorphine 3件: 5, 6, 7
20 DRD1 10件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Morphine addiction, Alcoholism D07870 Dopamine 4件: 6, 7, 74, 299
21 DRD1 10件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Morphine addiction, Alcoholism D08339 Pergolide 1件: 6
22 DRD1 10件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Morphine addiction, Alcoholism D09886 Dexpramipexole 1件: 2
23 DRD1 10件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Morphine addiction, Alcoholism D11431 Tavapadon 1件: 6
24 DRD1 10件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Morphine addiction, Alcoholism D11839 Foslevodopa 1件: 6
25 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D00059 Levodopa 6件: 6, 17, 90, 140, 164, 201
26 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D00136 Haloperidol 1件: 8
27 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D00270 Chlorpromazine 1件: 254
28 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D00426 Risperidone 5件: 8, 156, 179, 187, 206
29 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D00454 Olanzapine 2件: 2, 8
30 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D00560 Pimozide 1件: 2
31 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D00726 Metoclopramide 2件: 46, 51
32 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D00987 Cabergoline 3件: 6, 74, 75
33 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D01044 Flupentixol 1件: 97
34 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D01164 Aripiprazole 2件: 6, 206
35 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D01226 Sulpiride 2件: 6, 70
36 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D01348 Terguride 2件: 51, 86
37 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D01448 Trifluoperazine 2件: 283, 284
38 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D01745 Domperidone 5件: 6, 13, 17, 51, 230
39 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D02666 Iloperidone 1件: 6
40 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D03165 Bromocriptine 2件: 6, 74
41 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D05575 Pramipexole 3件: 2, 6, 20
42 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D05768 Rotigotine 1件: 6
43 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D07305 Piribedil 1件: 6
44 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D07309 Melperone 1件: 6
45 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D07460 Apomorphine 3件: 5, 6, 7
46 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D07593 Buspirone 2件: 6, 51
47 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D07868 Domperidone 5件: 6, 13, 17, 51, 230
48 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D07870 Dopamine 4件: 6, 7, 74, 299
49 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D08132 Lisuride 2件: 6, 86
50 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D08339 Pergolide 1件: 6
51 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D08456 Quetiapine 2件: 6, 13
52 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D08489 Ropinirole 4件: 2, 6, 74, 309
53 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D08590 Tiapride 1件: 8
54 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D08636 Trifluoperazine 2件: 283, 284
55 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D09397 Pardoprunox 1件: 6
56 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D09886 Dexpramipexole 1件: 2
57 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D09953 Pridopidine 3件: 2, 6, 8
58 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D09997 Cariprazine 1件: 21
59 DRD2 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism D11839 Foslevodopa 1件: 6
60 DRD3 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D00059 Levodopa 6件: 6, 17, 90, 140, 164, 201
61 DRD3 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D00454 Olanzapine 2件: 2, 8
62 DRD3 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D01164 Aripiprazole 2件: 6, 206
63 DRD3 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D05575 Pramipexole 3件: 2, 6, 20
64 DRD3 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D07305 Piribedil 1件: 6
65 DRD3 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D07870 Dopamine 4件: 6, 7, 74, 299
66 DRD3 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D08132 Lisuride 2件: 6, 86
67 DRD3 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D08489 Ropinirole 4件: 2, 6, 74, 309
68 DRD3 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D09397 Pardoprunox 1件: 6
69 DRD3 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D09886 Dexpramipexole 1件: 2
70 DRD3 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D11839 Foslevodopa 1件: 6
71 DRD4 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D00059 Levodopa 6件: 6, 17, 90, 140, 164, 201
72 DRD4 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D00283 Clozapine 1件: 6
73 DRD4 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D00454 Olanzapine 2件: 2, 8
74 DRD4 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D05575 Pramipexole 3件: 2, 6, 20
75 DRD4 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D07870 Dopamine 4件: 6, 7, 74, 299
76 DRD4 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D08132 Lisuride 2件: 6, 86
77 DRD4 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D08489 Ropinirole 4件: 2, 6, 74, 309
78 DRD4 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D09886 Dexpramipexole 1件: 2
79 DRD4 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse D11839 Foslevodopa 1件: 6
80 DRD5 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Dopaminergic synapse D00059 Levodopa 6件: 6, 17, 90, 140, 164, 201
81 DRD5 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Dopaminergic synapse D07870 Dopamine 4件: 6, 7, 74, 299
82 DRD5 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Dopaminergic synapse D09886 Dexpramipexole 1件: 2
83 DRD5 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Dopaminergic synapse D11431 Tavapadon 1件: 6
84 DRD5 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Dopaminergic synapse D11839 Foslevodopa 1件: 6
85 DHFR2 5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, Antifolate resistance D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331