Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	CA5B	[2] Nitrogen metabolism, Metabolic pathways	D00218	Acetazolamide	[8] 13, 86, 90, 115, 154, 155, 225, 230
2	CA5B	[2] Nitrogen metabolism, Metabolic pathways	D07871	Dorzolamide	[1] 90
3	ADRA2A	[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	D07540	Brimonidine	[2] 13, 90
4	ADRA2B	[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	D07540	Brimonidine	[2] 13, 90
5	ADRA2C	[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	D07540	Brimonidine	[2] 13, 90
6	DDC	[9] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Seroto ...	D00558	Carbidopa	[7] 6, 13, 17, 90, 140, 164, 201
7	DRD1	[10] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap ...	D00059	Levodopa	[6] 6, 17, 90, 140, 164, 201
8	DRD2	[8] Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap jun ...	D00059	Levodopa	[6] 6, 17, 90, 140, 164, 201
9	DRD3	[2] Neuroactive ligand-receptor interaction, Dopaminergic synapse	D00059	Levodopa	[6] 6, 17, 90, 140, 164, 201
10	DRD4	[2] Neuroactive ligand-receptor interaction, Dopaminergic synapse	D00059	Levodopa	[6] 6, 17, 90, 140, 164, 201

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