Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	CNR1	[2] Thermogenesis, Retrograde endocannabinoid signaling	D00306	Dronabinol	[8] 2, 8, 13, 36, 46, 96, 271, 298
2	CNR1	[2] Thermogenesis, Retrograde endocannabinoid signaling	D05099	Nabilone	[3] 6, 13, 127
3	CNR1	[2] Thermogenesis, Retrograde endocannabinoid signaling	D05731	Rimonabant	[1] 193
4	CNR1	[2] Thermogenesis, Retrograde endocannabinoid signaling	D10915	Cannabidiol	[20] 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
5	MAPK14	[16] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripote ...	D09639	Losmapimod	[2] 113, 222
6	MAPK14	[16] Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripote ...	D10959	Neflamapimod	[1] 8
7	GABRA1	[2] Retrograde endocannabinoid signaling, Taste transduction	D00225	Alprazolam	[2] 8, 75
8	GABRA1	[2] Retrograde endocannabinoid signaling, Taste transduction	D00280	Clonazepam	[1] 6
9	GABRA1	[2] Retrograde endocannabinoid signaling, Taste transduction	D00293	Diazepam	[3] 46, 155, 298
10	GABRA1	[2] Retrograde endocannabinoid signaling, Taste transduction	D00365	Lorazepam	[1] 36

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