DDrare
Disease
Drug
Target Gene/Pathway
問合せ先
EN
Target Gene/Pathway
Pathway
/
Gene
Search
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Other
Search results
10
50
100
ALL
entries per page:
Showing 1 to 10 of 56 entries
Filter by
Reset
|
No.
KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
指定難病告示番号
1
MAPK14
💬
1. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
62件:
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
62件:
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
1. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
ロスマピモド
Losmapimod
2件:
113
113
,
222
💬
1. MAPK14
×
告示番号
日本語名
英語名
113
筋ジストロフィー
Muscular dystrophy
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
2
MAPK14
💬
2. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
62件:
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
62件:
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
2. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
ネフラマピモド
Neflamapimod
1件:
8
8
💬
2. MAPK14
×
告示番号
日本語名
英語名
8
ハンチントン病
Huntington disease
3
CSF2
💬
3. CSF2
×
Name
Full Name
CSF2
colony stimulating factor 2
16件:
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
JAK-STAT signaling pathway
,
Hematopoietic cell lineage
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Shigellosis
,
Amoebiasis
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Coronavirus disease - COVID-19
,
Transcriptional misregulation in cancer
,
Acute myeloid leukemia
,
Rheumatoid arthritis
16件:
Cytokine-cytokine receptor interaction
,
JAK-STAT signaling pathway
,
Hematopoietic cell lineage
, ...
Otilimab
Otilimab
💬
3. CSF2
×
Name
Other Names
Otilimab
Otilimab (USAN)
Otilimab (genetical recombination) (JAN)
オチリマブ
オティリマブ
Otilimab
1件:
46
46
💬
3. CSF2
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
4
FCER1A
💬
4. FCER1A
×
Name
Full Name
FCER1A
Fc fragment of IgE receptor Ia
4件:
Sphingolipid signaling pathway
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Fc epsilon RI signaling pathway
,
Asthma
4件:
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Fc epsilon RI signaling pathw
...
Omalizumab
Omalizumab
💬
4. FCER1A
×
Name
Other Names
Omalizumab
Omalizumab (USAN/INN)
Omalizumab (genetical recombination) (JAN)
Xolair (TN)
オマリズマブ
ゾレア
Omalizumab
7件:
46
46
,
53
,
65
,
98
,
162
,
226
,
299
💬
4. FCER1A
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
53
シェーグレン症候群
Sjogren syndrome
65
原発性免疫不全症候群
Primary immunodeficiency
98
好酸球性消化管疾患
Eosinophilic gastrointestinal disease
162
類天疱瘡（後天性表皮水疱症を含む。）
Pemphigoid
226
間質性膀胱炎（ハンナ型）
Interstitial cystitis with Hunners ulcer
299
嚢胞性線維症;膵囊胞線維症
Cystic fibrosis
5
ALOX5
💬
5. ALOX5
×
Name
Full Name
ALOX5
arachidonate 5-lipoxygenase
6件:
Arachidonic acid metabolism
Arachidonic acid metabolism
,
Metabolic pathways
,
Fc epsilon RI signaling pathway
,
Serotonergic synapse
,
Ovarian steroidogenesis
,
Toxoplasmosis
6件:
Arachidonic acid metabolism
,
Metabolic pathways
,
Fc epsilon RI signaling pathway
,
Serotonergic s
...
Zileuton
Zileuton
💬
5. ALOX5
×
Name
Other Names
Zileuton
Zileuton (USP/INN)
Zyflo (TN)
ジロートン
Zileuton
3件:
85
85
,
160
,
164
💬
5. ALOX5
×
告示番号
日本語名
英語名
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
160
先天性魚鱗癬
Congenital ichthyosis
164
眼皮膚白皮症
Oculocutaneous albinism
6
ALOX5
💬
6. ALOX5
×
Name
Full Name
ALOX5
arachidonate 5-lipoxygenase
6件:
Arachidonic acid metabolism
Arachidonic acid metabolism
,
Metabolic pathways
,
Fc epsilon RI signaling pathway
,
Serotonergic synapse
,
Ovarian steroidogenesis
,
Toxoplasmosis
6件:
Arachidonic acid metabolism
,
Metabolic pathways
,
Fc epsilon RI signaling pathway
,
Serotonergic s
...
Oxatomide
Oxatomide
💬
6. ALOX5
×
Name
Other Names
Oxatomide
Oxatomide (JAN/USAN/INN)
Celtect (TN)
オキサトミド
Oxatomide
1件:
113
113
💬
6. ALOX5
×
告示番号
日本語名
英語名
113
筋ジストロフィー
Muscular dystrophy
7
FYN
💬
7. FYN
×
Name
Full Name
FYN
FYN proto-oncogene, Src family tyrosine kinase
14件:
Sphingolipid signaling pathway
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Axon guidance
,
Osteoclast differentiation
,
Focal adhesion
,
Adherens junction
,
Platelet activation
,
Natural killer cell mediated cytotoxicity
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Cholinergic synapse
,
Prion disease
,
Pathogenic Escherichia coli infection
,
Viral myocarditis
14件:
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Axon guidance
,
Osteoclast di
...
Dasatinib
Dasatinib
💬
7. FYN
×
Name
Other Names
Dasatinib
Dasatinib (JAN/INN)
ダサチニブ
Dasatinib
2件:
51
51
,
85
💬
7. FYN
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
8
FYN
💬
8. FYN
×
Name
Full Name
FYN
FYN proto-oncogene, Src family tyrosine kinase
14件:
Sphingolipid signaling pathway
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Axon guidance
,
Osteoclast differentiation
,
Focal adhesion
,
Adherens junction
,
Platelet activation
,
Natural killer cell mediated cytotoxicity
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Cholinergic synapse
,
Prion disease
,
Pathogenic Escherichia coli infection
,
Viral myocarditis
14件:
Sphingolipid signaling pathway
,
Phospholipase D signaling pathway
,
Axon guidance
,
Osteoclast di
...
Dasatinib
Dasatinib
💬
8. FYN
×
Name
Other Names
Dasatinib
Dasatinib (USAN)
Dasatinib hydrate (JAN)
Sprycel (TN)
ダサチニブ水和物
スプリセル
Dasatinib
2件:
51
51
,
85
💬
8. FYN
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
9
IL4
💬
9. IL4
×
Name
Full Name
IL4
interleukin 4
16件:
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
PI3K-Akt signaling pathway
,
JAK-STAT signaling pathway
,
Hematopoietic cell lineage
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Intestinal immune network for IgA production
,
Leishmaniasis
,
Pathways in cancer
,
Asthma
,
Autoimmune thyroid disease
,
Inflammatory bowel disease
,
Allograft rejection
16件:
Cytokine-cytokine receptor interaction
,
PI3K-Akt signaling pathway
,
JAK-STAT signaling pathway
, ...
Binetrakin
Binetrakin
💬
9. IL4
×
Name
Other Names
Binetrakin
Binetrakin (USAN/INN)
ビネトラキン
Binetrakin
1件:
46
46
💬
9. IL4
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
10
IL5
💬
10. IL5
×
Name
Full Name
IL5
interleukin 5
13件:
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
JAK-STAT signaling pathway
,
Hematopoietic cell lineage
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
Intestinal immune network for IgA production
,
Pathways in cancer
,
Asthma
,
Autoimmune thyroid disease
,
Inflammatory bowel disease
,
Allograft rejection
13件:
Cytokine-cytokine receptor interaction
,
JAK-STAT signaling pathway
,
Hematopoietic cell lineage
, ...
Mepolizumab
Mepolizumab
💬
10. IL5
×
Name
Other Names
Mepolizumab
Mepolizumab (USAN/INN)
Mepolizumab (genetical recombination) (JAN)
Nucala (TN)
メポリズマブ
ヌーカラ
Mepolizumab
4件:
44
44
,
45
,
98
,
162
💬
10. IL5
×
告示番号
日本語名
英語名
44
多発血管炎性肉芽腫症;ウェゲナー肉芽腫症
Wegener granulomatosis
45
好酸球性多発血管炎性肉芽腫症;アレルギー性肉芽腫性血管炎;チャーグ・ストラウス症候群
Eosinophilic granulomatosis with Polyangiitis
98
好酸球性消化管疾患
Eosinophilic gastrointestinal disease
162
類天疱瘡（後天性表皮水疱症を含む。）
Pemphigoid