DDrare
Disease
Drug
Target Gene/Pathway
問合せ先
EN
Target Gene/Pathway
Pathway
/
Gene
Search
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Other
Search results
10
50
100
ALL
entries per page:
Showing 1 to 10 of 67 entries
Filter by
Reset
|
No.
KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
指定難病告示番号
1
MAPK14
💬
1. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
62件:
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
62件:
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
1. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
ロスマピモド
Losmapimod
2件:
113
113
,
222
💬
1. MAPK14
×
告示番号
日本語名
英語名
113
筋ジストロフィー
Muscular dystrophy
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
2
MAPK14
💬
2. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
62件:
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
62件:
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
2. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
ネフラマピモド
Neflamapimod
1件:
8
8
💬
2. MAPK14
×
告示番号
日本語名
英語名
8
ハンチントン病
Huntington disease
3
CYP17A1
💬
3. CYP17A1
×
Name
Full Name
CYP17A1
cytochrome P450 family 17 subfamily A member 1
6件:
Steroid hormone biosynthesis
Steroid hormone biosynthesis
,
Metabolic pathways
,
Ovarian steroidogenesis
,
Prolactin signaling pathway
,
Cortisol synthesis and secretion
,
Cushing syndrome
6件:
Steroid hormone biosynthesis
,
Metabolic pathways
,
Ovarian steroidogenesis
,
Prolactin signaling p
...
Ketoconazole
Ketoconazole
💬
3. CYP17A1
×
Name
Other Names
Ketoconazole
Ketoconazole (JP18/USP)
Nizoral (TN)
Xolegel (TN)
ケトコナゾール
略語 KCZ
ニゾラール
Ketoconazole
3件:
8
8
,
13
,
75
💬
3. CYP17A1
×
告示番号
日本語名
英語名
8
ハンチントン病
Huntington disease
13
多発性硬化症／視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
75
クッシング病
Cushing disease
4
CYP17A1
💬
4. CYP17A1
×
Name
Full Name
CYP17A1
cytochrome P450 family 17 subfamily A member 1
6件:
Steroid hormone biosynthesis
Steroid hormone biosynthesis
,
Metabolic pathways
,
Ovarian steroidogenesis
,
Prolactin signaling pathway
,
Cortisol synthesis and secretion
,
Cushing syndrome
6件:
Steroid hormone biosynthesis
,
Metabolic pathways
,
Ovarian steroidogenesis
,
Prolactin signaling p
...
Levoketoconazole
Levoketoconazole
💬
4. CYP17A1
×
Name
Other Names
Levoketoconazole
Levoketoconazole (USAN/INN)
Recorlev (TN)
レボケトコナゾール
Levoketoconazole
1件:
75
75
💬
4. CYP17A1
×
告示番号
日本語名
英語名
75
クッシング病
Cushing disease
5
ESR1
💬
5. ESR1
×
Name
Full Name
ESR1
estrogen receptor 1
9件:
Endocrine resistance
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Endocrine and other factor-regulated calcium reabsorption
,
Pathways in cancer
,
Proteoglycans in cancer
,
Chemical carcinogenesis - receptor activation
,
Breast cancer
9件:
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone s
...
Estradiol
Estradiol
💬
5. ESR1
×
Name
Other Names
Estradiol
Estradiol (JAN/USP/INN)
Climara (TN)
Divigel (TN)
Estrace (TN)
Estraderm (TN)
Estrasorb (TN)
Estring (TN)
Estrogel (TN)
Innofem (TN)
Vagifem (TN)
Vivelle (TN)
IMVEXXY
MENOSTAR
MINIVELLE
VIVELLE-DOT
DOTTI
ESTRADIOL TRANSDERMAL SYSTEM
ESTRADIOL VAGINAL
ESTRADIOL VAGINAL CREAM
LYLLANA
YUVAFEM
エストラジオール
エストラーナ
ジュリナ
ディビゲル
ル・エストロジェル
Estradiol
7件:
13
13
,
46
,
49
,
65
,
76
,
226
,
299
💬
5. ESR1
×
告示番号
日本語名
英語名
13
多発性硬化症／視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
65
原発性免疫不全症候群
Primary immunodeficiency
76
下垂体性ゴナドトロピン分泌亢進症
Pituitary gonadotropin secretion hyperthyroidism
226
間質性膀胱炎（ハンナ型）
Interstitial cystitis with Hunners ulcer
299
嚢胞性線維症;膵囊胞線維症
Cystic fibrosis
6
ESR1
💬
6. ESR1
×
Name
Full Name
ESR1
estrogen receptor 1
9件:
Endocrine resistance
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Endocrine and other factor-regulated calcium reabsorption
,
Pathways in cancer
,
Proteoglycans in cancer
,
Chemical carcinogenesis - receptor activation
,
Breast cancer
9件:
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone s
...
Estriol
Estriol
💬
6. ESR1
×
Name
Other Names
Estriol
Estriol (JP18/USP)
Estriel (TN)
エストリオール
エストリール
ホーリン
Estriol
2件:
13
13
,
227
💬
6. ESR1
×
告示番号
日本語名
英語名
13
多発性硬化症／視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
227
オスラー病;遺伝性出血性末梢血管拡張症
Osler disease
7
ESR1
💬
7. ESR1
×
Name
Full Name
ESR1
estrogen receptor 1
9件:
Endocrine resistance
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Endocrine and other factor-regulated calcium reabsorption
,
Pathways in cancer
,
Proteoglycans in cancer
,
Chemical carcinogenesis - receptor activation
,
Breast cancer
9件:
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone s
...
Danazol
Danazol
💬
7. ESR1
×
Name
Other Names
Danazol
Danazol (JP18/USP/INN)
Danocrine (TN)
ダナゾール
ボンゾール
Danazol
5件:
60
60
,
63
,
64
,
65
,
285
💬
7. ESR1
×
告示番号
日本語名
英語名
60
再生不良性貧血
Aplastic anemia
63
特発性血小板減少性紫斑病;一次性免疫性血小板減少症
Idiopathic thrombocytopenic purpura
64
血栓性血小板減少性紫斑病
Thrombotic thrombocytopenic purpura
65
原発性免疫不全症候群
Primary immunodeficiency
285
ファンコニ貧血
Fanconi anemia
8
ESR1
💬
8. ESR1
×
Name
Full Name
ESR1
estrogen receptor 1
9件:
Endocrine resistance
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Endocrine and other factor-regulated calcium reabsorption
,
Pathways in cancer
,
Proteoglycans in cancer
,
Chemical carcinogenesis - receptor activation
,
Breast cancer
9件:
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone s
...
Ethinyl estradiol
Ethinyl estradiol
💬
8. ESR1
×
Name
Other Names
Ethinyl estradiol
Ethinyl estradiol (USP)
Ethinylestradiol (JP18/INN)
Estinyl (TN)
エチニルエストラジオール
プロセキソール
Ethinylestradiol
4件:
13
13
,
46
,
49
,
299
💬
8. ESR1
×
告示番号
日本語名
英語名
13
多発性硬化症／視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
299
嚢胞性線維症;膵囊胞線維症
Cystic fibrosis
9
ESR1
💬
9. ESR1
×
Name
Full Name
ESR1
estrogen receptor 1
9件:
Endocrine resistance
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Endocrine and other factor-regulated calcium reabsorption
,
Pathways in cancer
,
Proteoglycans in cancer
,
Chemical carcinogenesis - receptor activation
,
Breast cancer
9件:
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone s
...
Mestranol
Mestranol
💬
9. ESR1
×
Name
Other Names
Mestranol
Mestranol (JP18/USP/INN)
メストラノール
Mestranol
2件:
46
46
,
49
💬
9. ESR1
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
10
ESR1
💬
10. ESR1
×
Name
Full Name
ESR1
estrogen receptor 1
9件:
Endocrine resistance
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone signaling pathway
,
Endocrine and other factor-regulated calcium reabsorption
,
Pathways in cancer
,
Proteoglycans in cancer
,
Chemical carcinogenesis - receptor activation
,
Breast cancer
9件:
Endocrine resistance
,
Estrogen signaling pathway
,
Prolactin signaling pathway
,
Thyroid hormone s
...
Fulvestrant
Fulvestrant
💬
10. ESR1
×
Name
Other Names
Fulvestrant
Fulvestrant (JAN/USP/INN)
Faslodex (TN)
フルベストラント
フェソロデックス
Fulvestrant
2件:
49
49
,
86
💬
10. ESR1
×
告示番号
日本語名
英語名
49
全身性エリテマトーデス
Systemic lupus erythematosus
86
肺動脈性肺高血圧症
Pulmonary arterial hypertension