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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
指定難病告示番号
1
MAPK14
💬
1. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
62件:
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
62件:
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
1. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
ロスマピモド
Losmapimod
2件:
113
113
,
222
💬
1. MAPK14
×
告示番号
日本語名
英語名
113
筋ジストロフィー
Muscular dystrophy
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
2
MAPK14
💬
2. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
62件:
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
62件:
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
2. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
ネフラマピモド
Neflamapimod
1件:
8
8
💬
2. MAPK14
×
告示番号
日本語名
英語名
8
ハンチントン病
Huntington disease
3
FGFR1
💬
3. FGFR1
×
Name
Full Name
FGFR1
fibroblast growth factor receptor 1
16件:
MAPK signaling pathway
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
PI3K-Akt signaling pathway
,
Adherens junction
,
Signaling pathways regulating pluripotency of stem cells
,
Thermogenesis
,
Regulation of actin cytoskeleton
,
Parathyroid hormone synthesis, secretion and action
,
Pathways in cancer
,
Proteoglycans in cancer
,
Prostate cancer
,
Melanoma
,
Breast cancer
,
Central carbon metabolism in cancer
16件:
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathwa
...
Nintedanib
Nintedanib
💬
3. FGFR1
×
Name
Other Names
Nintedanib
Nintedanib (USAN/INN)
Ofev (TN)
ニンテダニブ
Nintedanib
5件:
51
51
,
85
,
89
,
227
,
228
💬
3. FGFR1
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
227
オスラー病;遺伝性出血性末梢血管拡張症
Osler disease
228
閉塞性細気管支炎
Bronchiolitis obliterans
4
FGFR1
💬
4. FGFR1
×
Name
Full Name
FGFR1
fibroblast growth factor receptor 1
16件:
MAPK signaling pathway
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
PI3K-Akt signaling pathway
,
Adherens junction
,
Signaling pathways regulating pluripotency of stem cells
,
Thermogenesis
,
Regulation of actin cytoskeleton
,
Parathyroid hormone synthesis, secretion and action
,
Pathways in cancer
,
Proteoglycans in cancer
,
Prostate cancer
,
Melanoma
,
Breast cancer
,
Central carbon metabolism in cancer
16件:
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathwa
...
Infigratinib
Infigratinib
💬
4. FGFR1
×
Name
Other Names
Infigratinib
Infigratinib (USAN/INN)
インフィグラチニブ
Infigratinib
1件:
276
276
💬
4. FGFR1
×
告示番号
日本語名
英語名
276
軟骨無形成症
Achondroplasia
5
FGFR3
💬
5. FGFR3
×
Name
Full Name
FGFR3
fibroblast growth factor receptor 3
13件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Signaling pathways regulating pluripotency of stem cells
,
Regulation of actin cytoskeleton
,
Pathways in cancer
,
MicroRNAs in cancer
,
Bladder cancer
,
Central carbon metabolism in cancer
13件:
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1
...
Nintedanib
Nintedanib
💬
5. FGFR3
×
Name
Other Names
Nintedanib
Nintedanib (USAN/INN)
Ofev (TN)
ニンテダニブ
Nintedanib
5件:
51
51
,
85
,
89
,
227
,
228
💬
5. FGFR3
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
227
オスラー病;遺伝性出血性末梢血管拡張症
Osler disease
228
閉塞性細気管支炎
Bronchiolitis obliterans
6
FGFR3
💬
6. FGFR3
×
Name
Full Name
FGFR3
fibroblast growth factor receptor 3
13件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Signaling pathways regulating pluripotency of stem cells
,
Regulation of actin cytoskeleton
,
Pathways in cancer
,
MicroRNAs in cancer
,
Bladder cancer
,
Central carbon metabolism in cancer
13件:
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1
...
Infigratinib
Infigratinib
💬
6. FGFR3
×
Name
Other Names
Infigratinib
Infigratinib (USAN/INN)
インフィグラチニブ
Infigratinib
1件:
276
276
💬
6. FGFR3
×
告示番号
日本語名
英語名
276
軟骨無形成症
Achondroplasia
7
FGFR2
💬
7. FGFR2
×
Name
Full Name
FGFR2
fibroblast growth factor receptor 2
13件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Signaling pathways regulating pluripotency of stem cells
,
Regulation of actin cytoskeleton
,
Pathways in cancer
,
Prostate cancer
,
Gastric cancer
,
Central carbon metabolism in cancer
13件:
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1
...
Palifermin
Palifermin
💬
7. FGFR2
×
Name
Other Names
Palifermin
Palifermin (USAN/INN)
Kepivance (TN)
パリフェルミン
Palifermin
5件:
13
13
,
36
,
38
,
39
,
65
💬
7. FGFR2
×
告示番号
日本語名
英語名
13
多発性硬化症／視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
36
表皮水疱症
Epidermolysis bullosa
38
スティーヴンス・ジョンソン症候群;皮膚粘膜眼症候群
Stevens-Johnson syndrome
39
中毒性表皮壊死症
Toxic epidermal necrolysis
65
原発性免疫不全症候群
Primary immunodeficiency
8
FGFR2
💬
8. FGFR2
×
Name
Full Name
FGFR2
fibroblast growth factor receptor 2
13件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Signaling pathways regulating pluripotency of stem cells
,
Regulation of actin cytoskeleton
,
Pathways in cancer
,
Prostate cancer
,
Gastric cancer
,
Central carbon metabolism in cancer
13件:
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1
...
Nintedanib
Nintedanib
💬
8. FGFR2
×
Name
Other Names
Nintedanib
Nintedanib (USAN/INN)
Ofev (TN)
ニンテダニブ
Nintedanib
5件:
51
51
,
85
,
89
,
227
,
228
💬
8. FGFR2
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
227
オスラー病;遺伝性出血性末梢血管拡張症
Osler disease
228
閉塞性細気管支炎
Bronchiolitis obliterans
9
FGFR2
💬
9. FGFR2
×
Name
Full Name
FGFR2
fibroblast growth factor receptor 2
13件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Signaling pathways regulating pluripotency of stem cells
,
Regulation of actin cytoskeleton
,
Pathways in cancer
,
Prostate cancer
,
Gastric cancer
,
Central carbon metabolism in cancer
13件:
EGFR tyrosine kinase inhibitor resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1
...
Infigratinib
Infigratinib
💬
9. FGFR2
×
Name
Other Names
Infigratinib
Infigratinib (USAN/INN)
インフィグラチニブ
Infigratinib
1件:
276
276
💬
9. FGFR2
×
告示番号
日本語名
英語名
276
軟骨無形成症
Achondroplasia
10
IGF1R
💬
10. IGF1R
×
Name
Full Name
IGF1R
insulin like growth factor 1 receptor
29件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Oocyte meiosis
,
Autophagy - animal
,
Endocytosis
,
mTOR signaling pathway
,
PI3K-Akt signaling pathway
,
AMPK signaling pathway
,
Longevity regulating pathway
,
Longevity regulating pathway - multiple species
,
Focal adhesion
,
Adherens junction
,
Signaling pathways regulating pluripotency of stem cells
,
Long-term depression
,
Ovarian steroidogenesis
,
Progesterone-mediated oocyte maturation
,
Pathways in cancer
,
Transcriptional misregulation in cancer
,
Proteoglycans in cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Breast cancer
,
Hepatocellular carcinoma
29件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
Ras si
...
Mecasermin
Mecasermin
💬
10. IGF1R
×
Name
Other Names
Mecasermin
Mecasermin (USAN/INN)
Mecasermin (genetical recombination) (JAN)
Increlex (TN)
Myotrophin (TN)
メカセルミン
ソマゾン
Mecasermin
6件:
65
65
,
78
,
96
,
168
,
265
,
299
💬
10. IGF1R
×
告示番号
日本語名
英語名
65
原発性免疫不全症候群
Primary immunodeficiency
78
下垂体前葉機能低下症
Hypopituitarism
96
クローン病;回腸末端炎
Crohn disease
168
エーラス・ダンロス症候群
Ehlers-Danlos syndrome
265
脂肪萎縮症
Lipodystrophy
299
嚢胞性線維症;膵囊胞線維症
Cystic fibrosis