Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	PIK3CA	[72] Inositol phosphate metabolism, Metabolic pathways, Platinum drug resistance, Ras signaling path ...	D11011	Alpelisib	[1] 138
2	PIK3CA	[72] Inositol phosphate metabolism, Metabolic pathways, Platinum drug resistance, Ras signaling path ...	D11158	Leniolisib	[2] 53, 65
3	PIK3CB	[72] Inositol phosphate metabolism, Metabolic pathways, Platinum drug resistance, Ras signaling path ...	D11158	Leniolisib	[2] 53, 65
4	PIK3CD	[72] Inositol phosphate metabolism, Metabolic pathways, Platinum drug resistance, Ras signaling path ...	D11158	Leniolisib	[2] 53, 65
5	PIK3CD	[72] Inositol phosphate metabolism, Metabolic pathways, Platinum drug resistance, Ras signaling path ...	D11437	Parsaclisib	[3] 35, 53, 61
6	PRKCB	[51] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, NF-kappa B signaling pat ...	D11935	Enzastaurin	[1] 168
7	PRKCD	[10] Vascular smooth muscle contraction, NOD-like receptor signaling pathway, Fc gamma R-mediated ph ...	D09671	Sotrastaurin	[1] 97
8	PRKCE	[9] Sphingolipid signaling pathway, Vascular smooth muscle contraction, Tight junction, Fc gamma R-m ...	D09671	Sotrastaurin	[1] 97
9	MAP2K1	[62] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, ...	D09666	Selumetinib	[1] 34
10	MAP2K1	[62] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, ...	D10175	Trametinib	[4] 2, 34, 279, 280

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