Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	IFNG	[6] TGF-beta signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I ...	D04242	Fontolizumab	[1] 46
2	IFNG	[6] TGF-beta signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I ...	D11120	Emapalumab	[3] 49, 65, 107
3	SMAD7	[1] TGF-beta signaling pathway	D10956	Mongersen	[2] 96, 97
4	RGMA	[1] TGF-beta signaling pathway	D11355	Elezanumab	[1] 13
5	ROCK1	[4] Vascular smooth muscle contraction, TGF-beta signaling pathway, Tight junction, Yersinia infecti ...	D07941	Fasudil	[4] 2, 5, 7, 51
6	TGFB1	[4] TGF-beta signaling pathway, Th17 cell differentiation, Toxoplasmosis, Tuberculosis	D09620	Fresolimumab	[3] 51, 85, 222
7	TGFB2	[3] TGF-beta signaling pathway, Toxoplasmosis, Tuberculosis	D09620	Fresolimumab	[3] 51, 85, 222
8	TGFB3	[3] TGF-beta signaling pathway, Toxoplasmosis, Tuberculosis	D09620	Fresolimumab	[3] 51, 85, 222
9	TNF	[9] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll- ...	D00742	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
10	TNF	[9] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll- ...	D00754	Thalidomide	[20] 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331

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