Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[21] MAPK signaling pathway, Cytokine-cytokine receptor interaction, Necroptosis, Cellular senescenc ...

Rilonacept 💬

[4] 51, 106, 107, 266 💬

2

[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...

Rilonacept 💬

[4] 51, 106, 107, 266 💬

3

[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa ...

Canakinumab 💬

[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬

Disease ID	Name
46	Malignant rheumatoid arthritis
56	Behcet disease
84	Sarcoidosis
106	Cryopyrin-associated periodic syndrome
107	Juvenile idiopathic arthritis
108	TNF receptor-associated periodic syndrome
113	Muscular dystrophy
266	Familial mediterranean fever
267	Hyper-IgD syndrome
269	Pyogenic arthritis

4

[13] MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, O ...

[18] 2, 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
13	Multiple sclerosis/Neuromyelitis optica
15	Inclusion body myositis
28	Systemic amyloidosis
37	Generalised pustular psoriasis
41	Giant cell arteritis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
56	Behcet disease
65	Primary immunodeficiency
84	Sarcoidosis
86	Pulmonary arterial hypertension
97	Ulcerative colitis
106	Cryopyrin-associated periodic syndrome
107	Juvenile idiopathic arthritis
266	Familial mediterranean fever
299	Cystic fibrosis

5

[7] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Amoebiasis, Human T-cell leu ...

[18] 2, 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
13	Multiple sclerosis/Neuromyelitis optica
15	Inclusion body myositis
28	Systemic amyloidosis
37	Generalised pustular psoriasis
41	Giant cell arteritis
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
50	Dermatomyositis
56	Behcet disease
65	Primary immunodeficiency
84	Sarcoidosis
86	Pulmonary arterial hypertension
97	Ulcerative colitis
106	Cryopyrin-associated periodic syndrome
107	Juvenile idiopathic arthritis
266	Familial mediterranean fever
299	Cystic fibrosis

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